Table 3
(continued)
Reference
and study
Location
Design
Study
dates
Population sample size
Exposure
assessment
Pesticides/
metabolites
Outcomes of interest
Main pyrethroid
findings
(3-PBA), 21 (3-PBA,
!50th percentile transDCCA), and total disomy
(3-PBA)
No association with
DBCA
Imai et al.,
2014
[30]
Japan
Crosssectional
study
2002–
2003
323 healthy men
Spot urine sample (at the time
of semen
sampling)
3-PBA
Semen analysis
No association between
3-PBA levels and sperm
parameters (semen volume, motility, concentration, total number of sperm
and of motile sperm)
Radwan
et al., 2014
[31]
Poland
Crosssectional
study
2008–
2011
334 men with normal
semen parameters or with
slight oligospermia
attending an infertility
clinic
Spot urine sample (on the day
of semen and
blood sampling)
Metabolites of
pyrethroids
(3-PBA, cisDCCA, transDCCA, DBCA)
Semen analysis and plasma
levels of testosterone, FSH,
and estradiol
Levels of 3-PBA,
TDCCA, and cis-DCCA
associated with the % of
sperm with abnormal morphology (!50th percentile
cis-DCCA, trans-DCCA,
!50th percentile sum),
decrease in sperm concentration (!50th percentile
TDCCA), level of testosterone (!50th percentile
trans-DCCA),
and
computer-aided semen
analysis (CASA) parameters (!50th percentile
3-PBA, DBCA)
272
A.-M. Saillenfait and S. Malard