Identification
Screening
Eligibility
Inclusion
Records retrieved in
MEDLINE/PubMed
(n = 183)
Total records
screened for eligibility
(n = 146)
Full-text articles
screened for inclusion
(n = 38)
Final studies to be
included in the review
(n = 38)
Records excluded on the basis of: title and/or
abstract; no focus on the topic at all; ecotoxicity
studies in model organisms not quantifying NSAID
levels in the natural water reservoir; (n= 37)
Records excluded based on eligibility criteria:
artificial samples with added NSAIDs; NSAIDs were
not determined or quantified; NSAID metabolites
were determined but not NSAID; samples did not
come from a natural fresh wáter source; (n= 108)
Fig. 1 PRISMA flow chart of studies identified in the systematic review of the occurrence of
NSAIDS in freshwater samples
Identification
Screening
Eligibility
Inclusion
Records retrieved in
MEDLINE/PubMed
(n = 82)
Total records
screened for eligibility
(n = 50)
Full-text articles
screened for inclusion
(n = 9)
Final studies to be
included in the review
(n = 9)
Records excluded on the basis of: title and/or
abstract; no focus on the topic at all; reviews or
systematic reviews; studies about compounds from
marine organisms with potential antiinflammatory
effect; (n= 32)
Records excluded based on eligibility criteria:
studies lacking data on concentrations of at least
one NSAID; NSAIDs were measured in other
type(s) of water but not saline; ecotoxicity studies in
marine organisms not quantifying environmental
NSAID levels; methods for NSAID degradation,
extraction and/or analysis were developed for
saline waters but using artificial or spiked wáter
samples; (n= 41)
Fig. 2 Selection of studies retrieved for the systematic review of the presence of NSAIDS in saline
waters
Worldwide Occurrence, Detection, and Fate of Nonsteroidal Anti-inflammatory. . .
59
Screening
Eligibility
Inclusion
Records retrieved in
MEDLINE/PubMed
(n = 183)
Total records
screened for eligibility
(n = 146)
Full-text articles
screened for inclusion
(n = 38)
Final studies to be
included in the review
(n = 38)
Records excluded on the basis of: title and/or
abstract; no focus on the topic at all; ecotoxicity
studies in model organisms not quantifying NSAID
levels in the natural water reservoir; (n= 37)
Records excluded based on eligibility criteria:
artificial samples with added NSAIDs; NSAIDs were
not determined or quantified; NSAID metabolites
were determined but not NSAID; samples did not
come from a natural fresh wáter source; (n= 108)
Fig. 1 PRISMA flow chart of studies identified in the systematic review of the occurrence of
NSAIDS in freshwater samples
Identification
Screening
Eligibility
Inclusion
Records retrieved in
MEDLINE/PubMed
(n = 82)
Total records
screened for eligibility
(n = 50)
Full-text articles
screened for inclusion
(n = 9)
Final studies to be
included in the review
(n = 9)
Records excluded on the basis of: title and/or
abstract; no focus on the topic at all; reviews or
systematic reviews; studies about compounds from
marine organisms with potential antiinflammatory
effect; (n= 32)
Records excluded based on eligibility criteria:
studies lacking data on concentrations of at least
one NSAID; NSAIDs were measured in other
type(s) of water but not saline; ecotoxicity studies in
marine organisms not quantifying environmental
NSAID levels; methods for NSAID degradation,
extraction and/or analysis were developed for
saline waters but using artificial or spiked wáter
samples; (n= 41)
Fig. 2 Selection of studies retrieved for the systematic review of the presence of NSAIDS in saline
waters
Worldwide Occurrence, Detection, and Fate of Nonsteroidal Anti-inflammatory. . .
59