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43. Stancová V et al (2015) Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen
on gene expression of antioxidant enzymes in zebrafish (Danio rerio). Environ Toxicol
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44. van den Brandhof E-J, Montforts M (2010) Fish embryo toxicity of carbamazepine, diclofenac
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rerio) early life stages. Environ Sci Pollut Res 23(18):18832–18841. https://doi.org/10.1007/
s11356-016-7092-4
46. Zivna D et al (2016) The effects of salicylic acid on juvenile zebrafish danio rerio under flowthrough conditions. Bull Environ Contam Toxicol 97(3):323–330. https://doi.org/10.1007/
s00128-016-1877-5
47. Xu C et al (2019) Long-term exposure to the non-steroidal anti-inflammatory drug (NSAID)
naproxen causes thyroid disruption in zebrafish at environmentally relevant concentrations. Sci
Total Environ 676:387–395. https://doi.org/10.1016/j.scitotenv.2019.04.323
48. Diniz MS et al (2015) Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis
byproducts in zebrafish (Danio rerio). Sci Total Environ 505:282–289. https://doi.org/10.1016/
j.scitotenv.2014.09.103
49. Melvin SD (2016) Oxidative stress, energy storage, and swimming performance of
Limnodynastes peronii tadpoles exposed to a sub-lethal pharmaceutical mixture throughout
development. Chemosphere 150:790–797. https://doi.org/10.1016/j.chemosphere.2015.09.034
50. Veldhoen N et al (2014) Effects of acute exposure to the non-steroidal anti-inflammatory drug
ibuprofen on the developing north american bullfrog ( Rana catesbeiana ) tadpole. Environ Sci
Technol 48(17):10439–10447. https://doi.org/10.1021/es502539g
51. Jones HS et al (2012) Metabolism of ibuprofen in zebrafish larvae. Xenobiotica 42
(11):1069–1075. https://doi.org/10.3109/00498254.2012.684410
52. Bebianno MJ et al (2017) Transcriptional and cellular effects of paracetamol in the oyster
Crassostrea gigas. Ecotoxicol Environ Saf 144:258–267. https://doi.org/10.1016/j.ecoenv.2017.
06.034
53. Kwak K et al (2018) Chronic toxicity and endocrine disruption of naproxen in freshwater
waterfleas and fish, and steroidogenic alteration using H295R cell assay. Chemosphere
204:156–162. https://doi.org/10.1016/j.chemosphere.2018.04.035
54. do Amaral DF et al (2019) Sub-lethal effects induced by a mixture of different pharmaceutical
drugs in predicted environmentally relevant concentrations on Lithobates catesbeianus (Shaw,
1802) (Anura, ranidae) tadpoles. Environ Sci Pollut Res 26(1):600–616. https://doi.org/10.
1007/s11356-018-3656-9
Overview of Non-steroidal Anti-inflammatory Drugs as Emerging Contaminants
53
10.1016/j.scitotenv.2015.05.088
40. Zivna D et al (2015) Effect of salicylic acid on early life stages of common carp (Cyprinus
carpio). Environ Toxicol Pharmacol 40(1):319–325. https://doi.org/10.1016/j.etap.2015.06.018
41. Galar-Martínez M et al (2016) Oxidative stress and genotoxicity induced by ketorolac on the
common carp Cyprinus Carpio. Environ Toxicol 31(9):1035–1043. https://doi.org/10.1002/tox.
22113
42. Pérez-Coyotl I et al (2017) DNA damage and cytotoxicity induced on common carp by
pollutants in water from an urban reservoir. Madín reservoir, a case study. Chemosphere
185:789–797. https://doi.org/10.1016/j.chemosphere.2017.07.072
43. Stancová V et al (2015) Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen
on gene expression of antioxidant enzymes in zebrafish (Danio rerio). Environ Toxicol
Pharmacol 40(2):343–348. https://doi.org/10.1016/j.etap.2015.07.009
44. van den Brandhof E-J, Montforts M (2010) Fish embryo toxicity of carbamazepine, diclofenac
and metoprolol. Ecotoxicol Environ Saf 73(8):1862–1866. https://doi.org/10.1016/j.ecoenv.
2010.08.031
45. Li Q et al (2016) Acute toxicity and histopathological effects of naproxen in zebrafish (Danio
rerio) early life stages. Environ Sci Pollut Res 23(18):18832–18841. https://doi.org/10.1007/
s11356-016-7092-4
46. Zivna D et al (2016) The effects of salicylic acid on juvenile zebrafish danio rerio under flowthrough conditions. Bull Environ Contam Toxicol 97(3):323–330. https://doi.org/10.1007/
s00128-016-1877-5
47. Xu C et al (2019) Long-term exposure to the non-steroidal anti-inflammatory drug (NSAID)
naproxen causes thyroid disruption in zebrafish at environmentally relevant concentrations. Sci
Total Environ 676:387–395. https://doi.org/10.1016/j.scitotenv.2019.04.323
48. Diniz MS et al (2015) Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis
byproducts in zebrafish (Danio rerio). Sci Total Environ 505:282–289. https://doi.org/10.1016/
j.scitotenv.2014.09.103
49. Melvin SD (2016) Oxidative stress, energy storage, and swimming performance of
Limnodynastes peronii tadpoles exposed to a sub-lethal pharmaceutical mixture throughout
development. Chemosphere 150:790–797. https://doi.org/10.1016/j.chemosphere.2015.09.034
50. Veldhoen N et al (2014) Effects of acute exposure to the non-steroidal anti-inflammatory drug
ibuprofen on the developing north american bullfrog ( Rana catesbeiana ) tadpole. Environ Sci
Technol 48(17):10439–10447. https://doi.org/10.1021/es502539g
51. Jones HS et al (2012) Metabolism of ibuprofen in zebrafish larvae. Xenobiotica 42
(11):1069–1075. https://doi.org/10.3109/00498254.2012.684410
52. Bebianno MJ et al (2017) Transcriptional and cellular effects of paracetamol in the oyster
Crassostrea gigas. Ecotoxicol Environ Saf 144:258–267. https://doi.org/10.1016/j.ecoenv.2017.
06.034
53. Kwak K et al (2018) Chronic toxicity and endocrine disruption of naproxen in freshwater
waterfleas and fish, and steroidogenic alteration using H295R cell assay. Chemosphere
204:156–162. https://doi.org/10.1016/j.chemosphere.2018.04.035
54. do Amaral DF et al (2019) Sub-lethal effects induced by a mixture of different pharmaceutical
drugs in predicted environmentally relevant concentrations on Lithobates catesbeianus (Shaw,
1802) (Anura, ranidae) tadpoles. Environ Sci Pollut Res 26(1):600–616. https://doi.org/10.
1007/s11356-018-3656-9
Overview of Non-steroidal Anti-inflammatory Drugs as Emerging Contaminants
53