85. Sousa MA, Gonçalves C, Cunha E, Hajšlová J, Alpendurada MF (2011) Cleanup strategies
and advantages in the determination of several therapeutic classes of pharmaceuticals in
wastewater samples by SPE–LC–MS/MS. Anal Bioanal Chem 399(2):807–822
86. Richardson ML, Bowron JM (1985) The fate of pharmaceutical chemicals in the aquatic
environment. J Pharm Pharmacol 37(1):1–12
87. Hoeger B, Köllner B, Dietrich DR, Hitzfeld B (2005) Water-borne diclofenac affects kidney
and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario). Aquat
Toxicol 75(1):53–64
88. Ribas JLC, Zampronio AR, Silva de Assis HC (2016) Effects of trophic exposure to diclofenac
and dexamethasone on hematological parameters and immune response in freshwater fish.
Environ Toxicol Chem 35(4):975–982
89. Mehinto AC, Hill EM, Tyler CR (2010) Uptake and biological effects of environmentally
relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in
rainbow trout (Oncorhynchus mykiss). Environ Sci Technol 44(6):2176–2182
90. Memmert U, Peither A, Burri R, Weber K, Schmidt T, Sumpter JP, Hartmann A (2013)
Diclofenac: new data on chronic toxicity and bioconcentration in fish. Environ Toxicol Chem
32(2):442–452
91. Van den Brandhof EJ, Montforts M (2010) Fish embryo toxicity of carbamazepine, diclofenac
and metoprolol. Ecotoxicol Environ Saf 73(8):1862–1866
92. Chen JB, Gao HW, Zhang YL, Zhang Y, Zhou XF, Li CQ, Gao HP (2014) Developmental
toxicity of diclofenac and elucidation of gene regulation in zebrafish (Danio rerio). Sci Rep
4:4841
93. Nassef M, Matsumoto S, Seki M, Khalil F, Kang IJ, Shimasaki Y et al (2010) Acute effects of
triclosan, diclofenac and carbamazepine on feeding performance of Japanese medaka fish
(Oryzias latipes). Chemosphere 80(9):1095–1100
94. Parolini M, Binelli A, Provini A (2011) Assessment of the potential cyto–genotoxicity of the
nonsteroidal anti-inflammatory drug (NSAID) diclofenac on the zebra mussel (Dreissena
polymorpha). Water Air Soil Pollut 217(1-4):589–601
95. Stepanova S, Praskova E, Chromcova L, Plhalova L, Prokes M, Blahova J, Svobodova Z
(2013) The effects of diclofenac on early life stages of common carp (Cyprinus carpio).
Environ Toxicol Pharmacol 35(3):454–460
96. Praskova E, Plhalova L, Chromcova L, Stepanova S, Bedanova I, Blahova J et al (2014)
Effects of subchronic exposure of diclofenac on growth, histopathological changes, and
oxidative stress in zebrafish (Danio rerio). Sci World J 2014:645737
97. Guiloski IC, Ribas JLC, da Silva Pereira L, Neves APP, de Assis HCS (2015) Effects of
trophic exposure to dexamethasone and diclofenac in freshwater fish. Ecotoxicol Environ Saf
114:204–211
98. Saucedo-Vence K, Dublán-García O, López-Martínez LX, Morachis-Valdes G, GalarMartínez M, Islas-Flores H, Gómez-Oliván LM (2015) Short and long-term exposure to
diclofenac alter oxidative stress status in common carp Cyprinus carpio. Ecotoxicology 24
(3):527–539
99. David A, Pancharatna K (2009) Effects of acetaminophen (paracetamol) in the embryonic
development of zebrafish, Danio rerio. J Appl Toxicol 29(7):597–602
100. Gómez-Oliván LM, Neri-Cruz N, Galar-Martínez M, Vieyra-Reyes P, García-Medina S,
Razo-Estrada C et al (2012) Assessing the oxidative stress induced by paracetamol spiked in
artificial sediment on Hyalella azteca. Water Air Soil Pollut 223(8):5097–5104
101. Antunes SC, Freitas R, Figueira E, Gonçalves F, Nunes B (2013) Biochemical effects of
acetaminophen in aquatic species: edible clams Venerupis decussata and Venerupis
philippinarum. Environ Sci Pollut Res 20(9):6658–6666
102. Ramos AS, Correia AT, Antunes SC, Gonçalves F, Nunes B (2014) Effect of acetaminophen
exposure in Oncorhynchus mykiss gills and liver: detoxification mechanisms, oxidative
defence system and peroxidative damage. Environ Toxicol Pharmacol 37(3):1221–1228
38
G. A. Elizalde-Velázquez and L. M. Gómez-Oliván
and advantages in the determination of several therapeutic classes of pharmaceuticals in
wastewater samples by SPE–LC–MS/MS. Anal Bioanal Chem 399(2):807–822
86. Richardson ML, Bowron JM (1985) The fate of pharmaceutical chemicals in the aquatic
environment. J Pharm Pharmacol 37(1):1–12
87. Hoeger B, Köllner B, Dietrich DR, Hitzfeld B (2005) Water-borne diclofenac affects kidney
and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario). Aquat
Toxicol 75(1):53–64
88. Ribas JLC, Zampronio AR, Silva de Assis HC (2016) Effects of trophic exposure to diclofenac
and dexamethasone on hematological parameters and immune response in freshwater fish.
Environ Toxicol Chem 35(4):975–982
89. Mehinto AC, Hill EM, Tyler CR (2010) Uptake and biological effects of environmentally
relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in
rainbow trout (Oncorhynchus mykiss). Environ Sci Technol 44(6):2176–2182
90. Memmert U, Peither A, Burri R, Weber K, Schmidt T, Sumpter JP, Hartmann A (2013)
Diclofenac: new data on chronic toxicity and bioconcentration in fish. Environ Toxicol Chem
32(2):442–452
91. Van den Brandhof EJ, Montforts M (2010) Fish embryo toxicity of carbamazepine, diclofenac
and metoprolol. Ecotoxicol Environ Saf 73(8):1862–1866
92. Chen JB, Gao HW, Zhang YL, Zhang Y, Zhou XF, Li CQ, Gao HP (2014) Developmental
toxicity of diclofenac and elucidation of gene regulation in zebrafish (Danio rerio). Sci Rep
4:4841
93. Nassef M, Matsumoto S, Seki M, Khalil F, Kang IJ, Shimasaki Y et al (2010) Acute effects of
triclosan, diclofenac and carbamazepine on feeding performance of Japanese medaka fish
(Oryzias latipes). Chemosphere 80(9):1095–1100
94. Parolini M, Binelli A, Provini A (2011) Assessment of the potential cyto–genotoxicity of the
nonsteroidal anti-inflammatory drug (NSAID) diclofenac on the zebra mussel (Dreissena
polymorpha). Water Air Soil Pollut 217(1-4):589–601
95. Stepanova S, Praskova E, Chromcova L, Plhalova L, Prokes M, Blahova J, Svobodova Z
(2013) The effects of diclofenac on early life stages of common carp (Cyprinus carpio).
Environ Toxicol Pharmacol 35(3):454–460
96. Praskova E, Plhalova L, Chromcova L, Stepanova S, Bedanova I, Blahova J et al (2014)
Effects of subchronic exposure of diclofenac on growth, histopathological changes, and
oxidative stress in zebrafish (Danio rerio). Sci World J 2014:645737
97. Guiloski IC, Ribas JLC, da Silva Pereira L, Neves APP, de Assis HCS (2015) Effects of
trophic exposure to dexamethasone and diclofenac in freshwater fish. Ecotoxicol Environ Saf
114:204–211
98. Saucedo-Vence K, Dublán-García O, López-Martínez LX, Morachis-Valdes G, GalarMartínez M, Islas-Flores H, Gómez-Oliván LM (2015) Short and long-term exposure to
diclofenac alter oxidative stress status in common carp Cyprinus carpio. Ecotoxicology 24
(3):527–539
99. David A, Pancharatna K (2009) Effects of acetaminophen (paracetamol) in the embryonic
development of zebrafish, Danio rerio. J Appl Toxicol 29(7):597–602
100. Gómez-Oliván LM, Neri-Cruz N, Galar-Martínez M, Vieyra-Reyes P, García-Medina S,
Razo-Estrada C et al (2012) Assessing the oxidative stress induced by paracetamol spiked in
artificial sediment on Hyalella azteca. Water Air Soil Pollut 223(8):5097–5104
101. Antunes SC, Freitas R, Figueira E, Gonçalves F, Nunes B (2013) Biochemical effects of
acetaminophen in aquatic species: edible clams Venerupis decussata and Venerupis
philippinarum. Environ Sci Pollut Res 20(9):6658–6666
102. Ramos AS, Correia AT, Antunes SC, Gonçalves F, Nunes B (2014) Effect of acetaminophen
exposure in Oncorhynchus mykiss gills and liver: detoxification mechanisms, oxidative
defence system and peroxidative damage. Environ Toxicol Pharmacol 37(3):1221–1228
38
G. A. Elizalde-Velázquez and L. M. Gómez-Oliván