Mytilus
galloprovincialis
25
μg/L
14 d
Accumulation of lipofuscin in tertiary lysosomes
Micronuclei frequency
"
LMS, CAT
#
Mezzelani et al. [7]
Danio rerio
1, 10, 100
μg/mL
1, 10, 100
μg/L
96 h
42 d
Developmental abnormalities (pericardial edema,
delayed hatching, scoliosis, elongation of heart, yolk
sac edema, pericardial edema)
Heart rate
#
AST, ALT, LDH
"
SOD, CAT, GSH, GPx, LPO, Na
+
/K
+
-ATPase
#
Histopathology: In liver (nuclear degeneration, necrosis, nuclear degeneration, cytoplasmatic degeneration,
cytoplasmatic vacuolation, sinusoid and pyknotic
nuclei)
Rangasamy et al.
[126]
Mefenamic
acid
Daphnia magna
0.39, 1.56, 6.5, 25, 100 mg/
L
1
 10
À5
, 0.0001, 0.001,
0.01, 0.1, 1 mg/L
48 h
21 d
EC
50
¼ 17.16 mg/L
Population growth rate
#
Collard et al. [127]
Moina
macrocopa
0.39, 1.56, 6.5, 25, 100 mg/
L
0.063, 0.125, 0.250, 0.500,
1 mg/L
48 h
7 d
EC
50
¼ 2.93 mg/L
Population growth rate
#
Collard et al. [127]
Danio rerio
0.001, 0.01, 0.1, 1 mg/L
14 d
GnRH2 mRNA, GnRHR2 mRNA, VTG1 mRNA,
CYP19B mRNA
"
HMGRA mRNA, HMGRB mRNA, CYP11A mRNA
#
Collard et al. [127]
(continued)
Introduction and Historical Findings That Focused Nonsteroidal. . .
27