Table 4
(continued)
NSAIDs
Species
Concentrations
Time Results
Source
GPx, GR, CAT,
#
LOEC
¼ 0.004 mg/L
Naproxen
Danio rerio
1, 100
μg/L
14 d
CAT mRNA, GST mRNA
"
Ucp-2 mRNA
#
Stancová et al. [120]
Danio rerio
0.001, 0.1, 5 mg/L
14 d
GPx, GR, GST, CAT
"
Histopathology: in the gills (hyperemia, widening of a
leaflet’s apex, desquamation of leaflet’s epithelium), in
the liver (hepatocytic trabeculae, hyperemia in liver
parenchyme)
Stancova et al. [121]
Danio rerio
10, 20, 50, 75, 100,
125, 150, 175, 200, 240 mg/
L
10, 20, 50, 75, 100,
125, 150, 175 mg/L
120 h
120 h
LC
50
¼ 115.2 mg/L
Developmental abnormalities (delayed hatching, pericardial edema, yolk sac edema, hemagglutination,
weak pigmentation, hemorrhage, yolk condensation,
tail not detached, axial malformation, tail twisting)
Heart rates
#
LC
50
¼ 147.6 mg/L
Developmental abnormalities (pericardial edema, yolk
sac edema, axial malformation)
Histopathology: swelling of hepatic cells , cell borders
became obscure, nuclei pyknosis occurred
Li et al. [122]
Cyprinus carpio
10, 50, 100, 200
μg/L
32 d
Developmental abnormalities (delayed hatching,
hyperpigmentation)
Histopathology: skin mucous cells and gill lamellas
deformations
Body weight and length, GST
"
GR, TBARS
#
LOEC
¼ 10
μg/L
Sehonova et al. [123]
Ketoprofen
Danio rerio
1, 3, 6, 9, 12 mg/L
550, 600, 650, 700, 750 mg/
L
144 h
96 h
LC
50
¼ 6.44
Æ 2.22 mg/L
LC
50
¼ 632.30
Æ 10.10 mg/L
Praskova et al. [124]
Cyprinus carpio
0.003, 2.1, 6.3, 21 mg/L
30 d
LOEC
¼ 0.003 mg/L
Delayed hatching
Body weight and length
"
Prášková et al. [125]
26
G. A. Elizalde-Velázquez and L. M. Gómez-Oliván