17. Gómez-Oliván LM et al (2014) DNA damage and oxidative stress induced by acetylsalicylic
acid in Daphnia magna. Comp Biochem Physiol C 164:21–26
18. Ziylan A, Ince NH (2011) The occurrence and fate of anti-inflammatory and analgesic pharmaceuticals in sewage and fresh water: treatability by conventional and non-conventional
processes. J Hazard Mater 187:24–36
19. Tambosi JL et al (2010) Recent research data on the removal of pharmaceuticals from sewage
treatment plants (STP). Quim Nova 33(2):411–420
20. Nikolaou A, Meric S, Fatta D (2007) Occurrence patterns of pharmaceuticals in water and
wastewater environments. Anal Bioanal Chem 387:1225–1234
21. Marchlewicz A, Guzik U, Wojcieszyńska D (2015) Over-the-counter monocyclic non-steroidal
anti-inflammatory drugs in environment – sources, risks, biodegradation. Water Air Soil Pollut
226:355
22. Picquet M (2013) Organometallics as catalysts in the fine chemical industry. Platin Met Rev
57:272–280
23. Ikehata K, Gamal El-Din M (2006) Aqueous pesticide degradation by hydrogen peroxide/
ultraviolet irradiation and Fenton-type advanced oxidation processes: a review. J Environ Eng
Sci 5:81–135
24. Johnson AC, Sumpter JP (2001) Removal of endocrine-disrupting chemicals in activated sludge
treatment works. Environ Sci Technol 35(24):4697–4703
25. Guzzellaa L, Ferettib D, Monarca S (2002) Advanced oxidation and adsorption technologies for
organic micropollutant removal from lake water used as drinking-water supply. Water Res
36:4307–4318
26. Ternes TA et al (2003) Ozonation: a tool for removal of pharmaceuticals, contrast media and
musk fragrances from wastewater? Water Res 37:1976–1982
27. Acuña V et al (2015) Balancing the health benefits and environmental risks of pharmaceuticals:
diclofenac as an example. Environ Int 85:327–333
28. Schwaiger J et al (2004) Toxic effects of the non-steroidal anti-inflammatory drug diclofenac
part I: histopathological alterations and bioaccumulation in rainbow trout. Aquat Toxicol
68:141–150
29. Barbosa M et al (2016) Occurrence and removal of organic micropollutants: an overview of the
watch list of EU Decision 2015/495. Water Res 94:257–279
30. Patrolecco L, Capri S, Ademollo N (2015) Occurrence of selected pharmaceuticals in the
principal sewage treatment plants in Rome (Italy) and in the receiving surface waters. Environ
Sci Pollut Res 22:5864–5876
31. Bu Q et al (2016) Assessing the persistence of pharmaceuticals in the aquatic environment:
challenges and needs. Emerg Contam 2(3):145–147
32. Vieno N, Sillanpää M (2014) Fate of diclofenac in municipal wastewater treatment plant – a
review. Environ Int 69:28–39
33. Zhang Y, Geissen S-U, Gal C (2008) Carbamazepine and diclofenac: removal in wastewater
treatment plants and occurrence in water bodies. Chemosphere 73(8):1151–1161
34. Corcoran J, Winter MJ, Tyler CR (2010) Pharmaceuticals in the aquatic environment: a critical
review of the evidence for health effects in fish. Crit Rev Toxicol 40(4):287–304
35. Saravanan M et al (2012) Effects of ibuprofen on hematological, biochemical and
enzymological parameters of blood in an Indian major carp, Cirrhinus mrigala. Environ
Toxicol Pharmacol 34:14–22
36. Luo Y et al (2014) A review on the occurrence of micropollutants in the aquatic environment
and their fate and removal during wastewater treatment. Sci Total Environ 473:619–641
37. Murdoch R, Hay A (2015) The biotransformation of ibuprofen to trihydroxyibuprofen in
activated sludge and by Variovorax Ibu-1. Biodegradation 26:105–113
38. Grenni P et al (2013) Degradation of Gemfibrozil and Naproxen in a river water ecosystem.
Microchem J 107:158–164
318
N. Ramírez-Durán et al.
acid in Daphnia magna. Comp Biochem Physiol C 164:21–26
18. Ziylan A, Ince NH (2011) The occurrence and fate of anti-inflammatory and analgesic pharmaceuticals in sewage and fresh water: treatability by conventional and non-conventional
processes. J Hazard Mater 187:24–36
19. Tambosi JL et al (2010) Recent research data on the removal of pharmaceuticals from sewage
treatment plants (STP). Quim Nova 33(2):411–420
20. Nikolaou A, Meric S, Fatta D (2007) Occurrence patterns of pharmaceuticals in water and
wastewater environments. Anal Bioanal Chem 387:1225–1234
21. Marchlewicz A, Guzik U, Wojcieszyńska D (2015) Over-the-counter monocyclic non-steroidal
anti-inflammatory drugs in environment – sources, risks, biodegradation. Water Air Soil Pollut
226:355
22. Picquet M (2013) Organometallics as catalysts in the fine chemical industry. Platin Met Rev
57:272–280
23. Ikehata K, Gamal El-Din M (2006) Aqueous pesticide degradation by hydrogen peroxide/
ultraviolet irradiation and Fenton-type advanced oxidation processes: a review. J Environ Eng
Sci 5:81–135
24. Johnson AC, Sumpter JP (2001) Removal of endocrine-disrupting chemicals in activated sludge
treatment works. Environ Sci Technol 35(24):4697–4703
25. Guzzellaa L, Ferettib D, Monarca S (2002) Advanced oxidation and adsorption technologies for
organic micropollutant removal from lake water used as drinking-water supply. Water Res
36:4307–4318
26. Ternes TA et al (2003) Ozonation: a tool for removal of pharmaceuticals, contrast media and
musk fragrances from wastewater? Water Res 37:1976–1982
27. Acuña V et al (2015) Balancing the health benefits and environmental risks of pharmaceuticals:
diclofenac as an example. Environ Int 85:327–333
28. Schwaiger J et al (2004) Toxic effects of the non-steroidal anti-inflammatory drug diclofenac
part I: histopathological alterations and bioaccumulation in rainbow trout. Aquat Toxicol
68:141–150
29. Barbosa M et al (2016) Occurrence and removal of organic micropollutants: an overview of the
watch list of EU Decision 2015/495. Water Res 94:257–279
30. Patrolecco L, Capri S, Ademollo N (2015) Occurrence of selected pharmaceuticals in the
principal sewage treatment plants in Rome (Italy) and in the receiving surface waters. Environ
Sci Pollut Res 22:5864–5876
31. Bu Q et al (2016) Assessing the persistence of pharmaceuticals in the aquatic environment:
challenges and needs. Emerg Contam 2(3):145–147
32. Vieno N, Sillanpää M (2014) Fate of diclofenac in municipal wastewater treatment plant – a
review. Environ Int 69:28–39
33. Zhang Y, Geissen S-U, Gal C (2008) Carbamazepine and diclofenac: removal in wastewater
treatment plants and occurrence in water bodies. Chemosphere 73(8):1151–1161
34. Corcoran J, Winter MJ, Tyler CR (2010) Pharmaceuticals in the aquatic environment: a critical
review of the evidence for health effects in fish. Crit Rev Toxicol 40(4):287–304
35. Saravanan M et al (2012) Effects of ibuprofen on hematological, biochemical and
enzymological parameters of blood in an Indian major carp, Cirrhinus mrigala. Environ
Toxicol Pharmacol 34:14–22
36. Luo Y et al (2014) A review on the occurrence of micropollutants in the aquatic environment
and their fate and removal during wastewater treatment. Sci Total Environ 473:619–641
37. Murdoch R, Hay A (2015) The biotransformation of ibuprofen to trihydroxyibuprofen in
activated sludge and by Variovorax Ibu-1. Biodegradation 26:105–113
38. Grenni P et al (2013) Degradation of Gemfibrozil and Naproxen in a river water ecosystem.
Microchem J 107:158–164
318
N. Ramírez-Durán et al.