28. Pascoe D, Karntanut W, Müller CT (2003) Do pharmaceuticals affect freshwater invertebrates?
A study with the cnidarian Hydra vulgaris. Chemosphere 51(6):521–528
29. Brandão FP, Pereira JL, Gonçalves F, Nunes B (2014) The impact of paracetamol on selected
biomarkers of the mollusc species Corbicula fluminea. Environ Toxicol 29(1):74–83
30. Parolini M, Binelli A, Cogni D, Riva C, Provini A (2009) An in vitro biomarker approach for
the evaluation of the ecotoxicity of non-steroidal anti-inflammatory drugs (NSAIDs). Toxicol In
Vitro 23(5):935–942
31. Parolini M, Binelli A, Cogni D, Provini A (2010) Multi-biomarker approach for the evaluation
of the cyto-genotoxicity of paracetamol on the zebra mussel (Dreissena polymorpha).
Chemosphere 79(5):489–498
32. de Oliveira LLD, Antunes SC, Gonçalves F, Rocha O, Nunes B (2016) Acute and chronic
ecotoxicological effects of four pharmaceuticals drugs on cladoceran Daphnia magna. Drug
Chem Toxicol 39(1):13–21
33. Liu Y, Wang L, Pan B, Wang C, Bao S, Nie X (2017) Toxic effects of diclofenac on life history
parameters and the expression of detoxification-related genes in Daphnia magna. Aquat
Toxicol 183:104–113
34. Haap T, Triebskorn R, Köhler HR (2008) Acute effects of diclofenac and DMSO to Daphnia
magna: immobilisation and hsp70-induction. Chemosphere 73(3):353–359
35. Parolini M, Quinn B, Binelli A, Provini A (2011) Cytotoxicity assessment of four pharmaceutical compounds on the zebra mussel (Dreissena polymorpha) haemocytes, gill and digestive
gland primary cell cultures. Chemosphere 84(1):91–100
36. Parolini M, Binelli A, Provini A (2011) Assessment of the potential cyto–genotoxicity of the
nonsteroidal anti-inflammatory drug (NSAID) diclofenac on the zebra mussel (Dreissena
polymorpha). Water Air Soil Pollut 217(1-4):589–601
37. Boisseaux P, Noury P, Thomas H, Garric J (2017) Immune responses in the aquatic gastropod
Lymnaea stagnalis under short-term exposure to pharmaceuticals of concern for immune
systems: Diclofenac, cyclophosphamide and cyclosporine A. Ecotoxicol Environ Saf
139:358–366
38. Nieto E, Corada-Fernández C, Hampel M, Lara-Martín PA, Sánchez-Argüello P, Blasco J
(2017) Effects of exposure to pharmaceuticals (diclofenac and carbamazepine) spiked sediments in the midge, Chironomus riparius (Diptera, Chironomidae). Sci Total Environ
609:715–723
39. Wang L, Peng Y, Nie X, Pan B, Ku P, Bao S (2016) Gene response of CYP360A, CYP314, and
GST and whole-organism changes in Daphnia magna exposed to ibuprofen. Comp Biochem
Physiol C Toxicol Pharmacol 179:49–56
40. Contardo-Jara V, Lorenz C, Pflugmacher S, Nützmann G, Kloas W, Wiegand C (2011)
Exposure to human pharmaceuticals Carbamazepine, Ibuprofen and Bezafibrate causes molecular effects in Dreissena polymorpha. Aquat Toxicol 105(3-4):428–437
41. Parolini M, Binelli A, Provini A (2011) Chronic effects induced by ibuprofen on the freshwater
bivalve Dreissena polymorpha. Ecotoxicol Environ Saf 74(6):1586–1594
42. Aguirre-Martínez GV, Del Valls AT, Martín-Díaz ML (2015) Yes, caffeine, ibuprofen, carbamazepine, novobiocin and tamoxifen have an effect on Corbicula fluminea (Müller, 1774).
Ecotoxicol Environ Saf 120:142–154
43. Pounds N, Maclean S, Webley M, Pascoe D, Hutchinson T (2008) Acute and chronic effects of
ibuprofen in the mollusc Planorbis carinatus (Gastropoda: Planorbidae). Ecotoxicol Environ
Saf 70(1):47–52
44. Quinn B, Gagné F, Blaise C (2009) Evaluation of the acute, chronic and teratogenic effects of a
mixture of eleven pharmaceuticals on the cnidarian, Hydra attenuata. Sci Total Environ 407
(3):1072–1079
160
M. Parolini
A study with the cnidarian Hydra vulgaris. Chemosphere 51(6):521–528
29. Brandão FP, Pereira JL, Gonçalves F, Nunes B (2014) The impact of paracetamol on selected
biomarkers of the mollusc species Corbicula fluminea. Environ Toxicol 29(1):74–83
30. Parolini M, Binelli A, Cogni D, Riva C, Provini A (2009) An in vitro biomarker approach for
the evaluation of the ecotoxicity of non-steroidal anti-inflammatory drugs (NSAIDs). Toxicol In
Vitro 23(5):935–942
31. Parolini M, Binelli A, Cogni D, Provini A (2010) Multi-biomarker approach for the evaluation
of the cyto-genotoxicity of paracetamol on the zebra mussel (Dreissena polymorpha).
Chemosphere 79(5):489–498
32. de Oliveira LLD, Antunes SC, Gonçalves F, Rocha O, Nunes B (2016) Acute and chronic
ecotoxicological effects of four pharmaceuticals drugs on cladoceran Daphnia magna. Drug
Chem Toxicol 39(1):13–21
33. Liu Y, Wang L, Pan B, Wang C, Bao S, Nie X (2017) Toxic effects of diclofenac on life history
parameters and the expression of detoxification-related genes in Daphnia magna. Aquat
Toxicol 183:104–113
34. Haap T, Triebskorn R, Köhler HR (2008) Acute effects of diclofenac and DMSO to Daphnia
magna: immobilisation and hsp70-induction. Chemosphere 73(3):353–359
35. Parolini M, Quinn B, Binelli A, Provini A (2011) Cytotoxicity assessment of four pharmaceutical compounds on the zebra mussel (Dreissena polymorpha) haemocytes, gill and digestive
gland primary cell cultures. Chemosphere 84(1):91–100
36. Parolini M, Binelli A, Provini A (2011) Assessment of the potential cyto–genotoxicity of the
nonsteroidal anti-inflammatory drug (NSAID) diclofenac on the zebra mussel (Dreissena
polymorpha). Water Air Soil Pollut 217(1-4):589–601
37. Boisseaux P, Noury P, Thomas H, Garric J (2017) Immune responses in the aquatic gastropod
Lymnaea stagnalis under short-term exposure to pharmaceuticals of concern for immune
systems: Diclofenac, cyclophosphamide and cyclosporine A. Ecotoxicol Environ Saf
139:358–366
38. Nieto E, Corada-Fernández C, Hampel M, Lara-Martín PA, Sánchez-Argüello P, Blasco J
(2017) Effects of exposure to pharmaceuticals (diclofenac and carbamazepine) spiked sediments in the midge, Chironomus riparius (Diptera, Chironomidae). Sci Total Environ
609:715–723
39. Wang L, Peng Y, Nie X, Pan B, Ku P, Bao S (2016) Gene response of CYP360A, CYP314, and
GST and whole-organism changes in Daphnia magna exposed to ibuprofen. Comp Biochem
Physiol C Toxicol Pharmacol 179:49–56
40. Contardo-Jara V, Lorenz C, Pflugmacher S, Nützmann G, Kloas W, Wiegand C (2011)
Exposure to human pharmaceuticals Carbamazepine, Ibuprofen and Bezafibrate causes molecular effects in Dreissena polymorpha. Aquat Toxicol 105(3-4):428–437
41. Parolini M, Binelli A, Provini A (2011) Chronic effects induced by ibuprofen on the freshwater
bivalve Dreissena polymorpha. Ecotoxicol Environ Saf 74(6):1586–1594
42. Aguirre-Martínez GV, Del Valls AT, Martín-Díaz ML (2015) Yes, caffeine, ibuprofen, carbamazepine, novobiocin and tamoxifen have an effect on Corbicula fluminea (Müller, 1774).
Ecotoxicol Environ Saf 120:142–154
43. Pounds N, Maclean S, Webley M, Pascoe D, Hutchinson T (2008) Acute and chronic effects of
ibuprofen in the mollusc Planorbis carinatus (Gastropoda: Planorbidae). Ecotoxicol Environ
Saf 70(1):47–52
44. Quinn B, Gagné F, Blaise C (2009) Evaluation of the acute, chronic and teratogenic effects of a
mixture of eleven pharmaceuticals on the cnidarian, Hydra attenuata. Sci Total Environ 407
(3):1072–1079
160
M. Parolini