without the damage of normal cells (NIH3T3) as well as the NIR-dominated release.
This novel biocompatible local drug delivery system based on CD hydrogels could
open an avenue for the combination of chemo- and photo-therapy.
Zhu et al. [53] reported a series of anticancer drug-loaded hydrogels based on
host-guest interaction of β-CDs and adamantanes. This injectable hydrogel using
CDs as cores could realize drug delivery efficiently and release drugs at mild acidic
condition resulting in effective killing of cancer cells. As shown in Fig. 10, they
synthesized oligoethylenediamine (with different degrees of polymerization)functionalized β-CD and diacrylic acid-terminated PEG first, following with
Michael addition between them generating a class of β-CD dendritic polymers
facilely. Then a prodrug was fabricated connecting a typical hydrophobic anticancer
Fig. 9 Schematic illustration of the supramolecular hydrogel prepared with PEG-modified
PAMAM and α-CD [24]
Fig. 10 Schematic illustration of the injectable supramolecular hydrogel based on CD dendrimers
[53]
492
Q. Zhao et al.
This novel biocompatible local drug delivery system based on CD hydrogels could
open an avenue for the combination of chemo- and photo-therapy.
Zhu et al. [53] reported a series of anticancer drug-loaded hydrogels based on
host-guest interaction of β-CDs and adamantanes. This injectable hydrogel using
CDs as cores could realize drug delivery efficiently and release drugs at mild acidic
condition resulting in effective killing of cancer cells. As shown in Fig. 10, they
synthesized oligoethylenediamine (with different degrees of polymerization)functionalized β-CD and diacrylic acid-terminated PEG first, following with
Michael addition between them generating a class of β-CD dendritic polymers
facilely. Then a prodrug was fabricated connecting a typical hydrophobic anticancer
Fig. 9 Schematic illustration of the supramolecular hydrogel prepared with PEG-modified
PAMAM and α-CD [24]
Fig. 10 Schematic illustration of the injectable supramolecular hydrogel based on CD dendrimers
[53]
492
Q. Zhao et al.