weight. These nanoparticles were evaluated in mice and clinically in patients. The
results supported the hypothesis that nanoparticle therapeutics can localize within
human solid tumors, and this may occur via the EPR effect [59–62] (Fig. 12).
Cyclodextrins and hyaluronic acid (HA) are very widely used in drug delivery
because they are water soluble, biocompatible, and biodegradable polysaccharides.
Notably, HA can also be recognized by various cancer cells that overexpress HA
receptors on their cytomembranes (CD44 and hyaluronan-mediated motility receptor
(RHAMM)); thus, it is often used in targeted drug delivery systems [63–68].
Liu and coworkers designed and prepared a β-CD grafted onto HA to form a
complex with adamplatin by host–guest interaction (Fig. 13). On the basis of the
Scheme 17 Preparation of tetradecavalent α-Man conjugate via Sonogashira cross-coupling and a
“click” reaction [32]
408
J. Liu et al.
results supported the hypothesis that nanoparticle therapeutics can localize within
human solid tumors, and this may occur via the EPR effect [59–62] (Fig. 12).
Cyclodextrins and hyaluronic acid (HA) are very widely used in drug delivery
because they are water soluble, biocompatible, and biodegradable polysaccharides.
Notably, HA can also be recognized by various cancer cells that overexpress HA
receptors on their cytomembranes (CD44 and hyaluronan-mediated motility receptor
(RHAMM)); thus, it is often used in targeted drug delivery systems [63–68].
Liu and coworkers designed and prepared a β-CD grafted onto HA to form a
complex with adamplatin by host–guest interaction (Fig. 13). On the basis of the
Scheme 17 Preparation of tetradecavalent α-Man conjugate via Sonogashira cross-coupling and a
“click” reaction [32]
408
J. Liu et al.