effect was verified by mice experiments, which suggested that HACE–MbCD nanoparticles provided more suppression of cancer growth and more apoptotic events in
tumor tissues than MbCD or HACE nanoparticles alone [58] (Fig. 11).
Camptothecin (CPT) is a well-known and highly cytotoxic chemical, which can
kill tumor cells, as well as normal cells, with weak selectivity. In addition, CPT is a
hydrophobic molecule that is difficult to transport through the cell membrane.
Therefore, attempting to avoid its side effects and improving its transportability
into cells have been attractive and challenging tasks for scientists. Using CRLX101,
a nanoparticle self-assembled from a linear cyclodextrin polymer conjugate with
CPT, Ribas and coworkers [31] tried to deliver the CPT to a specific site. With
sufficient host–guest interaction, the individual polymer strands cross-linked and
self-assembled into nanoparticles around 20 to 40 nm in diameter and 10% CPT by
Scheme 16 Hepta-amide cyclodextrin glycocluster [50]
14 Functionalized Cyclodextrins and Their Applications in Biodelivery
407
tumor tissues than MbCD or HACE nanoparticles alone [58] (Fig. 11).
Camptothecin (CPT) is a well-known and highly cytotoxic chemical, which can
kill tumor cells, as well as normal cells, with weak selectivity. In addition, CPT is a
hydrophobic molecule that is difficult to transport through the cell membrane.
Therefore, attempting to avoid its side effects and improving its transportability
into cells have been attractive and challenging tasks for scientists. Using CRLX101,
a nanoparticle self-assembled from a linear cyclodextrin polymer conjugate with
CPT, Ribas and coworkers [31] tried to deliver the CPT to a specific site. With
sufficient host–guest interaction, the individual polymer strands cross-linked and
self-assembled into nanoparticles around 20 to 40 nm in diameter and 10% CPT by
Scheme 16 Hepta-amide cyclodextrin glycocluster [50]
14 Functionalized Cyclodextrins and Their Applications in Biodelivery
407