above description, this delivery system would improve the water solubility of
adamplatin and decrease its toxicity. In an antitumor activity evaluation with
mice, this result was illustrated by comparison with cisplatin. The authors observed
that the HA platform provided targeted drug delivery action and transported the
adamplatin into cancer cells while exhibiting minimal uptake into normal
tissues [69].
14.3.4 Sensitive Molecules Transported by Cyclodextrin
Nanocarriers
Low levels of vitamin E (VE) have very adverse consequences, but VE is also very
sensitive to oxygen and light irradiation. To overcome this problem, Chen and
coworkers constructed a series of primary-rim-capped crowning β-CDs derivatives,
which could form host–guest complexes with VE and self-assembled particles.
These particles improved the stability of VE significantly and also showed obvious
temperature-responsive release [70] (Fig. 14).
Like VE, lutein is a very important nutrient. It is also a very unstable compound,
with low solubility in water. Ouyang and coworkers constructed a kind of lutein,
cyclodextrin, poloxamer 188, and Tween 80 complex, which improved the water
solubility tremendously (79.94 Æ 2.21 μg/mL, 406-fold). Interestingly, its dissolution rate and bioavailability were also improved remarkably, as demonstrated by
combined modeling and experimental methods [71] (Fig. 15).
Fig. 10 Effect of enhanced permeability and retention (EPR) on tumor targeting [55]
14 Functionalized Cyclodextrins and Their Applications in Biodelivery
409
adamplatin and decrease its toxicity. In an antitumor activity evaluation with
mice, this result was illustrated by comparison with cisplatin. The authors observed
that the HA platform provided targeted drug delivery action and transported the
adamplatin into cancer cells while exhibiting minimal uptake into normal
tissues [69].
14.3.4 Sensitive Molecules Transported by Cyclodextrin
Nanocarriers
Low levels of vitamin E (VE) have very adverse consequences, but VE is also very
sensitive to oxygen and light irradiation. To overcome this problem, Chen and
coworkers constructed a series of primary-rim-capped crowning β-CDs derivatives,
which could form host–guest complexes with VE and self-assembled particles.
These particles improved the stability of VE significantly and also showed obvious
temperature-responsive release [70] (Fig. 14).
Like VE, lutein is a very important nutrient. It is also a very unstable compound,
with low solubility in water. Ouyang and coworkers constructed a kind of lutein,
cyclodextrin, poloxamer 188, and Tween 80 complex, which improved the water
solubility tremendously (79.94 Æ 2.21 μg/mL, 406-fold). Interestingly, its dissolution rate and bioavailability were also improved remarkably, as demonstrated by
combined modeling and experimental methods [71] (Fig. 15).
Fig. 10 Effect of enhanced permeability and retention (EPR) on tumor targeting [55]
14 Functionalized Cyclodextrins and Their Applications in Biodelivery
409