14.2.2 Functionalization of Cyclodextrins on the Secondary Rim
14.2.2.1 Supramolecular Inclusion Complex Strategy
To functionalize the secondary rim, sometimes a supramolecular strategy also
works. Ueno and Breslow [19] designed a guest molecule conjugated with a
promodified part, meta-nitrophenyl tosylate, which would be caught by the
cyclodextrin via host–guest interaction to make a better chance for the tosyl(Ts)
group close to the hydroxyls on the secondary rim not these on the primary rim.
Scheme 9 Hexadifferentiated α-cyclodextrin (α-CD) procedure [3]
14 Functionalized Cyclodextrins and Their Applications in Biodelivery
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14.2.2.1 Supramolecular Inclusion Complex Strategy
To functionalize the secondary rim, sometimes a supramolecular strategy also
works. Ueno and Breslow [19] designed a guest molecule conjugated with a
promodified part, meta-nitrophenyl tosylate, which would be caught by the
cyclodextrin via host–guest interaction to make a better chance for the tosyl(Ts)
group close to the hydroxyls on the secondary rim not these on the primary rim.
Scheme 9 Hexadifferentiated α-cyclodextrin (α-CD) procedure [3]
14 Functionalized Cyclodextrins and Their Applications in Biodelivery
395