vii
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
v
Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
ix
1 Application of Neutralization and Freeze-Drying Technique
for the Preparation of the Beneficial in Drug Delivery
2-Hydroxypropyl-β-Cyclodextrin Complexes with Bioactive Molecules. . . . . . . . . 1
Eirini Christodoulou, Dimitrios Ntountaniotis, Georgios Leonis,
Thomas Mavromoustakos, and Georgia Valsami
2 Functionalized Carbon Nanohorns as Drug Delivery Platforms . . . . . . . . . . . . . . 13
Anastasios Stergiou and Nikos Tagmatarchis
3 Ultrasonics-Assisted Effective Isolation and Characterization
of Exosomes from Whole Organs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Burak Derkus and Emel Emregul
4 Aggregate Determination by Permeation Technique . . . . . . . . . . . . . . . . . . . . . . . 35
Phennapha Saokham and Thorsteinn Loftsson
5 Study of Candesartan Cilexetil: 2-Hydroxypropyl-β- Cyclodextrin
Interactions: A Computational Approach Using Steered
Molecular Dynamics Simulations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Sofia Kiriakidi and Thomas Mavromoustakos
6 Drug Delivery: Hydrophobic Drug Encapsulation into Amphiphilic Block
Copolymer Micelles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Angeliki Chroni, Varvara Chrysostomou, Athanasios Skandalis,
and Stergios Pispas
7 Multisensitive Polymeric Nanocontainers as Drug Delivery Systems:
Biological Evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
Maria Theodosiou, Theodora Koutsikou, and Eleni K. Efthimiadou
8 Drug Incorporation in the Drug Delivery System of Micelles . . . . . . . . . . . . . . . . 99
Evangelia Soumelidou, Simona Golič Grdadolnik,
and Thomas Mavromoustakos
9 Molecular Dynamics Protocols for the Study of Cyclodextrin
Drug Delivery Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
Georgios Leonis, Dimitrios Ntountaniotis, Eirini Christodoulou,
and Thomas Mavromoustakos
10 Drug Delivery Through Multifunctional Polypeptidic Hydrogels . . . . . . . . . . . . 127
Hermis Iatrou, Panagiota G. Fragouli, Dimitra Stavroulaki,
and Barbara Athanasiou
11 Polymersomes from Hybrids-Polypeptides for Drug Delivery Applications . . . . . 139
Hermis Iatrou, Panagiota G. Fragouli, Dimitris Skourtis,
and Ioanna Stavropoulou
Contents
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
v
Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
ix
1 Application of Neutralization and Freeze-Drying Technique
for the Preparation of the Beneficial in Drug Delivery
2-Hydroxypropyl-β-Cyclodextrin Complexes with Bioactive Molecules. . . . . . . . . 1
Eirini Christodoulou, Dimitrios Ntountaniotis, Georgios Leonis,
Thomas Mavromoustakos, and Georgia Valsami
2 Functionalized Carbon Nanohorns as Drug Delivery Platforms . . . . . . . . . . . . . . 13
Anastasios Stergiou and Nikos Tagmatarchis
3 Ultrasonics-Assisted Effective Isolation and Characterization
of Exosomes from Whole Organs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Burak Derkus and Emel Emregul
4 Aggregate Determination by Permeation Technique . . . . . . . . . . . . . . . . . . . . . . . 35
Phennapha Saokham and Thorsteinn Loftsson
5 Study of Candesartan Cilexetil: 2-Hydroxypropyl-β- Cyclodextrin
Interactions: A Computational Approach Using Steered
Molecular Dynamics Simulations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Sofia Kiriakidi and Thomas Mavromoustakos
6 Drug Delivery: Hydrophobic Drug Encapsulation into Amphiphilic Block
Copolymer Micelles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
Angeliki Chroni, Varvara Chrysostomou, Athanasios Skandalis,
and Stergios Pispas
7 Multisensitive Polymeric Nanocontainers as Drug Delivery Systems:
Biological Evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
Maria Theodosiou, Theodora Koutsikou, and Eleni K. Efthimiadou
8 Drug Incorporation in the Drug Delivery System of Micelles . . . . . . . . . . . . . . . . 99
Evangelia Soumelidou, Simona Golič Grdadolnik,
and Thomas Mavromoustakos
9 Molecular Dynamics Protocols for the Study of Cyclodextrin
Drug Delivery Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
Georgios Leonis, Dimitrios Ntountaniotis, Eirini Christodoulou,
and Thomas Mavromoustakos
10 Drug Delivery Through Multifunctional Polypeptidic Hydrogels . . . . . . . . . . . . 127
Hermis Iatrou, Panagiota G. Fragouli, Dimitra Stavroulaki,
and Barbara Athanasiou
11 Polymersomes from Hybrids-Polypeptides for Drug Delivery Applications . . . . . 139
Hermis Iatrou, Panagiota G. Fragouli, Dimitris Skourtis,
and Ioanna Stavropoulou
Contents