v
Amidst the sadness of endless mediocrity, which suffocates us everywhere, I
am comforted that somewhere, in an arch, some stubborn people are struggling to neutralize corruption.—“The Little Epsilon”, Odysseus Elytis
This drug delivery systems volume is dedicated to drugs that are unable to reach the desired
pharmaceutical drug target as a result of several limitations, mainly due to the lack of selectivity, poor targeting capacity, or undesired pharmacokinetic profile. The utilization of
proper “delivery vehicles” for such drugs can tailor their physical chemical properties and
enhance their efficacy, retaining their structures intact.
Techniques for preparing such systems are described in Chapters 1–3. Drug delivery
platforms are outlined in Chapters 4–13. Such platforms include cyclodextrins, micelles,
liposomes, polymeric, and nanotubes. These nanotechnology systems are studied using different biophysical techniques such as DSC, ITC, solid and liquid NMR spectroscopy, and
electrochemistry (Chapters 14–23).
All accumulated chapters aim toward one target: to provide readers with critical information to accomplish (a) the synthesis of nanosystems, thus supramolecular entities complexing with drugs; (b) their characterization; as well as (c) studying their physical-chemical
interactions that govern their stability and properties. Experimental details and notes not
found in the scientific literature to cover these three aspects of drug delivery systems are
provided by experts in the field. This volume is thus very useful for all scientists who study
or plan to study such systems.
We wish to thank all authors whose effort provided manuscripts that overcome “the
sadness of endless mediocrity” and build a foundation of solid knowledge on this growing
field. Rational design is restrained not only to novel structures but also to old ones which
decorate themselves with supramolecules that convert their disadvantages to advantages.
We also wish to thank Prof. John Walker for his valuable impact and all personnel of Springer
who “are struggling to neutralize corruption.”
Zografou, Greece
Thomas Mavromoustakos
Ioannina, Greece
Andreas G. Tzakos
Istanbul, Turkey
Serdar Durdagi
Preface
Amidst the sadness of endless mediocrity, which suffocates us everywhere, I
am comforted that somewhere, in an arch, some stubborn people are struggling to neutralize corruption.—“The Little Epsilon”, Odysseus Elytis
This drug delivery systems volume is dedicated to drugs that are unable to reach the desired
pharmaceutical drug target as a result of several limitations, mainly due to the lack of selectivity, poor targeting capacity, or undesired pharmacokinetic profile. The utilization of
proper “delivery vehicles” for such drugs can tailor their physical chemical properties and
enhance their efficacy, retaining their structures intact.
Techniques for preparing such systems are described in Chapters 1–3. Drug delivery
platforms are outlined in Chapters 4–13. Such platforms include cyclodextrins, micelles,
liposomes, polymeric, and nanotubes. These nanotechnology systems are studied using different biophysical techniques such as DSC, ITC, solid and liquid NMR spectroscopy, and
electrochemistry (Chapters 14–23).
All accumulated chapters aim toward one target: to provide readers with critical information to accomplish (a) the synthesis of nanosystems, thus supramolecular entities complexing with drugs; (b) their characterization; as well as (c) studying their physical-chemical
interactions that govern their stability and properties. Experimental details and notes not
found in the scientific literature to cover these three aspects of drug delivery systems are
provided by experts in the field. This volume is thus very useful for all scientists who study
or plan to study such systems.
We wish to thank all authors whose effort provided manuscripts that overcome “the
sadness of endless mediocrity” and build a foundation of solid knowledge on this growing
field. Rational design is restrained not only to novel structures but also to old ones which
decorate themselves with supramolecules that convert their disadvantages to advantages.
We also wish to thank Prof. John Walker for his valuable impact and all personnel of Springer
who “are struggling to neutralize corruption.”
Zografou, Greece
Thomas Mavromoustakos
Ioannina, Greece
Andreas G. Tzakos
Istanbul, Turkey
Serdar Durdagi
Preface