viii
12 Drug Delivery Systems Based on Modified Polysaccharides:
Synthesis and Characterization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
Aikaterini-Foteini Metaxa, Eleni Vrontaki, Eleni K. Efthimiadou,
and Thomas Mavromoustakos
13 Differential Scanning Calorimetry (DSC) on Sartan/Cyclodextrin
Delivery Formulations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
Nikolaos Naziris, Maria Chountoulesi, Dimitrios Ntountaniotis,
Thomas Mavromoustakos, and Costas Demetzos
14 Encapsulation of Small Drugs in a Supramolecule Enhances Solubility,
Stability, and Therapeutic Efficacy Against Glioblastoma Multiforme . . . . . . . . . 175
Antonis D. Tsiailanis, Alexander Renziehausen, Serdar Karakurt,
Tim Crook, Nelofer Syed, and Andreas G. Tzakos
15 Unveiling the Thermodynamic Aspects of Drug- Cyclodextrin
Interactions Through Isothermal Titration Calorimetry . . . . . . . . . . . . . . . . . . . 187
Maria V. Chatziathanasiadou, Thomas Mavromoustakos,
and Andreas G. Tzakos
16 Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG
and Rosin Esters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199
Ali Ben Taleb, Selcan Karakuş, Ezgi Tan, Merve Ilgar, Özlem Kutlu,
Devrim Gözüaçık, Hatice Mehtap Kutlu, and Ayben Kilislioğlu
17 Association of the Thermodynamics with the Functionality
of Thermoresponsive Chimeric Nanosystems . . . . . . . . . . . . . . . . . . . . . . . . . . . 221
Nikolaos Naziris, Athanasios Skandalis, Thomas Mavromoustakos,
Stergios Pispas, and Costas Demetzos
18 2D DOSY NMR: A Valuable Tool to Confirm the Complexation
in Drug Delivery Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235
Christos M. Chatzigiannis, Sofia Kiriakidi, Andreas G. Tzakos,
and Thomas Mavromoustakos
19 Drug-Encapsulated Cyclodextrin Nanosponges . . . . . . . . . . . . . . . . . . . . . . . . . 247
Maria Tannous, Fabrizio Caldera, Gjylije Hoti, Umberto Dianzani,
Roberta Cavalli, and Francesco Trotta
20 Electrochemistry Investigation of Drugs Encapsulated in Cyclodextrins . . . . . . . 285
Romana Sokolová and Ilaria Degano
21 A Differential Scanning Calorimetry (DSC) Experimental Protocol
for Evaluating the Modified Thermotropic Behavior of Liposomes
with Incorporated Guest Molecules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299
Maria Chountoulesi, Nikolaos Naziris, Thomas Mavromoustakos,
and Costas Demetzos
22 Applications of NMR in Drug:Cyclodextrin Complexes . . . . . . . . . . . . . . . . . . . 313
Dimitrios Ntountaniotis, Georgios Leonis, Eirini Christodoulou,
and Thomas Mavromoustakos
23 Construction of Peptide-Drug Conjugates for Selective Targeting
of Malignant Tumor Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327
Eirinaios I. Vrettos and Andreas G. Tzakos
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .339
Contents
12 Drug Delivery Systems Based on Modified Polysaccharides:
Synthesis and Characterization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
Aikaterini-Foteini Metaxa, Eleni Vrontaki, Eleni K. Efthimiadou,
and Thomas Mavromoustakos
13 Differential Scanning Calorimetry (DSC) on Sartan/Cyclodextrin
Delivery Formulations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
Nikolaos Naziris, Maria Chountoulesi, Dimitrios Ntountaniotis,
Thomas Mavromoustakos, and Costas Demetzos
14 Encapsulation of Small Drugs in a Supramolecule Enhances Solubility,
Stability, and Therapeutic Efficacy Against Glioblastoma Multiforme . . . . . . . . . 175
Antonis D. Tsiailanis, Alexander Renziehausen, Serdar Karakurt,
Tim Crook, Nelofer Syed, and Andreas G. Tzakos
15 Unveiling the Thermodynamic Aspects of Drug- Cyclodextrin
Interactions Through Isothermal Titration Calorimetry . . . . . . . . . . . . . . . . . . . 187
Maria V. Chatziathanasiadou, Thomas Mavromoustakos,
and Andreas G. Tzakos
16 Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG
and Rosin Esters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199
Ali Ben Taleb, Selcan Karakuş, Ezgi Tan, Merve Ilgar, Özlem Kutlu,
Devrim Gözüaçık, Hatice Mehtap Kutlu, and Ayben Kilislioğlu
17 Association of the Thermodynamics with the Functionality
of Thermoresponsive Chimeric Nanosystems . . . . . . . . . . . . . . . . . . . . . . . . . . . 221
Nikolaos Naziris, Athanasios Skandalis, Thomas Mavromoustakos,
Stergios Pispas, and Costas Demetzos
18 2D DOSY NMR: A Valuable Tool to Confirm the Complexation
in Drug Delivery Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235
Christos M. Chatzigiannis, Sofia Kiriakidi, Andreas G. Tzakos,
and Thomas Mavromoustakos
19 Drug-Encapsulated Cyclodextrin Nanosponges . . . . . . . . . . . . . . . . . . . . . . . . . 247
Maria Tannous, Fabrizio Caldera, Gjylije Hoti, Umberto Dianzani,
Roberta Cavalli, and Francesco Trotta
20 Electrochemistry Investigation of Drugs Encapsulated in Cyclodextrins . . . . . . . 285
Romana Sokolová and Ilaria Degano
21 A Differential Scanning Calorimetry (DSC) Experimental Protocol
for Evaluating the Modified Thermotropic Behavior of Liposomes
with Incorporated Guest Molecules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299
Maria Chountoulesi, Nikolaos Naziris, Thomas Mavromoustakos,
and Costas Demetzos
22 Applications of NMR in Drug:Cyclodextrin Complexes . . . . . . . . . . . . . . . . . . . 313
Dimitrios Ntountaniotis, Georgios Leonis, Eirini Christodoulou,
and Thomas Mavromoustakos
23 Construction of Peptide-Drug Conjugates for Selective Targeting
of Malignant Tumor Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327
Eirinaios I. Vrettos and Andreas G. Tzakos
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .339
Contents