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ester as the core and PEG as the external shield to address the challenges of conventional pharmaceutical formulations by optimizing
the pharmacokinetic and cellular bioavailability of ceranib-2.
2 Materials and Methods
Unless otherwise stated, all chemicals and materials used should be
pharmaceutical grade or pure, without further purification.
1. Resin ester powder.
2. Polyethylene glycol (PEG) 400.
3. Ceranib-2.
4. Sodium acetate.
5. Ethyl acetate.
6. Dimethyl sulfoxide (DMSO).
7. Buffer solution.
1. Dukes’ type B colorectal adenocarcinoma (SW480) cell line.
2. Cervix adenocarcinoma (HeLa) cell line.
3. Dulbecco’s modified Eagle medium (DMEM).
4. 10% (v/v) Fetal bovine serum (FBS).
2.1 Synthesis
of PREC-2 NPs
2.2 Cell Culture
Fig. 4 Pulsed horn ultrasonic cavitation
Ali Ben Taleb et al.
ester as the core and PEG as the external shield to address the challenges of conventional pharmaceutical formulations by optimizing
the pharmacokinetic and cellular bioavailability of ceranib-2.
2 Materials and Methods
Unless otherwise stated, all chemicals and materials used should be
pharmaceutical grade or pure, without further purification.
1. Resin ester powder.
2. Polyethylene glycol (PEG) 400.
3. Ceranib-2.
4. Sodium acetate.
5. Ethyl acetate.
6. Dimethyl sulfoxide (DMSO).
7. Buffer solution.
1. Dukes’ type B colorectal adenocarcinoma (SW480) cell line.
2. Cervix adenocarcinoma (HeLa) cell line.
3. Dulbecco’s modified Eagle medium (DMEM).
4. 10% (v/v) Fetal bovine serum (FBS).
2.1 Synthesis
of PREC-2 NPs
2.2 Cell Culture
Fig. 4 Pulsed horn ultrasonic cavitation
Ali Ben Taleb et al.