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sensitive drug and active ingredient without bulk high temperature, high pressure, or long reaction time [71]. In addition, this
technique has several advantages such as easy operation, low cost,
good energy efficiency, good dispersion stability, and low risk of
microbial contamination. The application of sonochemistrymediated particle size reduction and synthesis of nanosized particles with uniform size distribution and high stability have become
increasingly important [72].
Recently, ultrasound cavitation-assisted nanoencapsulation has
attracted more attention in many applications, including the design
of novel drug delivery systems, due to their properties such as simplicity, reproductivity, and low energy requirements. The synthesis
of nanocapsules using cavitation or an ultrasound approach is very
efficient and flexible to control several variables, such as size and
size distribution [73]. Various pulsed horn-based ultrasonic systems have been developed and introduced to sonochemistry and in
the design of drug delivery systems, which provide more efficient
particle reduction. This system allows ultrasonic waves to be
directed onto the electrode surface, where the horn and electrodes
are immersed in the solution with the ultrasound horn emitter
(Fig. 4). For efficient particle size reduction synthesis, several
parameters should be considered during ultrasonic cavitation process; these parameters include temperature, density, pulse time,
and pulse intensity [74]. At the present time, and to the best of our
knowledge, no other studies have investigated the effect of polymeric nanostructure form based on PEGylated rosin derivatives to
improve the solubility, cellular bioavailability, and pharmacokinetics of C-2. This study aims to develop a novel efficient, stable aqueous nanostructure drug delivery system for ceranib-2 (C-2), with
nanoparticles ranging in size between 10 and 350 nm using rosin
Organic phase with the drug
Solvent evaporation
Ultrasonication
Characterization
Aqueuos phase
with stabilizer
Fig. 3 Schematic diagram showing a preparation method of nanoparticle drug delivery system using solvent
evaporation mediated by ultrasonic cavitation
Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters
sensitive drug and active ingredient without bulk high temperature, high pressure, or long reaction time [71]. In addition, this
technique has several advantages such as easy operation, low cost,
good energy efficiency, good dispersion stability, and low risk of
microbial contamination. The application of sonochemistrymediated particle size reduction and synthesis of nanosized particles with uniform size distribution and high stability have become
increasingly important [72].
Recently, ultrasound cavitation-assisted nanoencapsulation has
attracted more attention in many applications, including the design
of novel drug delivery systems, due to their properties such as simplicity, reproductivity, and low energy requirements. The synthesis
of nanocapsules using cavitation or an ultrasound approach is very
efficient and flexible to control several variables, such as size and
size distribution [73]. Various pulsed horn-based ultrasonic systems have been developed and introduced to sonochemistry and in
the design of drug delivery systems, which provide more efficient
particle reduction. This system allows ultrasonic waves to be
directed onto the electrode surface, where the horn and electrodes
are immersed in the solution with the ultrasound horn emitter
(Fig. 4). For efficient particle size reduction synthesis, several
parameters should be considered during ultrasonic cavitation process; these parameters include temperature, density, pulse time,
and pulse intensity [74]. At the present time, and to the best of our
knowledge, no other studies have investigated the effect of polymeric nanostructure form based on PEGylated rosin derivatives to
improve the solubility, cellular bioavailability, and pharmacokinetics of C-2. This study aims to develop a novel efficient, stable aqueous nanostructure drug delivery system for ceranib-2 (C-2), with
nanoparticles ranging in size between 10 and 350 nm using rosin
Organic phase with the drug
Solvent evaporation
Ultrasonication
Characterization
Aqueuos phase
with stabilizer
Fig. 3 Schematic diagram showing a preparation method of nanoparticle drug delivery system using solvent
evaporation mediated by ultrasonic cavitation
Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters