598
A. Vinothkanna and S. Sekar
Table 24.6 Patents on
human theranostics using
PBPs as fluorophores
Diseases theranosed/theranostic
tool
Patents-source/country and
number
Bispecific antibodies and drug
delivery
US 7560110, IN
201717043418
Ly75 membrane protein target
as cancer theranostic
IN 3537/DELNP/2015
Tumor cell identification and
drug delivery
US 7238786
Colorectal cancer diagnosis and
drug delivery
US 8563682
Pancreatic cancer theranostic
US 8414894
Rheumatoid arthritis theranostic KR 1020080036215
Acute myeloid leukemia
theranostic
IN 6324/DELNP/2007
Abbreviations: IN—InPASS database, India; KR—KIPRIS
database, Korea; US—USPTO database, United States of America
Numbers with prefixes ‘IN’ and ‘KR’ represent application
numbers and prefix ‘US’ represent publication numbers of patents.
Numbers alone (without prefix alphabets) have to be entered in the
suitable search field of the corresponding country’s database. Such
prefix alphabets are meant for identifying the database
in cancer satisfying the dual role of targeting and killing cancer cells with phycobiliproteins. Phycocyanin (PC) conjugated nanohorns were effective in imaging to
visualize cancer progression and efficacy of treatment in vivo. In this case, it is
interesting to note that phycocyanin was known to mediate the production of Reactive Oxygen Species (ROS) photodynamically to kill cancer cells (Lin et al. 2019).
Similarly, many cancer theranostics were patented applying PBPs (Table 24.6). It is
common to find the usage of bispecific antibodies which carry both the diagnostic
system and drug for treatment.
24.2.7 Human Cellular/Cell Subset Diagnostic Applications
It is vital to note that certain cellular and subcellular features could be diagnosed
using PBPs as markers. To cite, identification of antigen-specific T cells using
enzymatically biotinylated tetramers of major histocompatibility complex (MHC)
coupled with mutant streptavidin-phycoerythrin conjugate was made. Such T cells
find application as an essential tool in vaccine development, tumor immunology,
autoimmunity, etc. (Ramachandiran et al. 2007). Subset analysis of leukocyte of
new world monkeys was performed using the fluorochrome phycoerythrin (Brok
et al. 2001). Co-localization of subcellular molecular interaction of macromolecules
(like protein, transcription factor, DNA, etc.) using three-dimensional multi-color
A. Vinothkanna and S. Sekar
Table 24.6 Patents on
human theranostics using
PBPs as fluorophores
Diseases theranosed/theranostic
tool
Patents-source/country and
number
Bispecific antibodies and drug
delivery
US 7560110, IN
201717043418
Ly75 membrane protein target
as cancer theranostic
IN 3537/DELNP/2015
Tumor cell identification and
drug delivery
US 7238786
Colorectal cancer diagnosis and
drug delivery
US 8563682
Pancreatic cancer theranostic
US 8414894
Rheumatoid arthritis theranostic KR 1020080036215
Acute myeloid leukemia
theranostic
IN 6324/DELNP/2007
Abbreviations: IN—InPASS database, India; KR—KIPRIS
database, Korea; US—USPTO database, United States of America
Numbers with prefixes ‘IN’ and ‘KR’ represent application
numbers and prefix ‘US’ represent publication numbers of patents.
Numbers alone (without prefix alphabets) have to be entered in the
suitable search field of the corresponding country’s database. Such
prefix alphabets are meant for identifying the database
in cancer satisfying the dual role of targeting and killing cancer cells with phycobiliproteins. Phycocyanin (PC) conjugated nanohorns were effective in imaging to
visualize cancer progression and efficacy of treatment in vivo. In this case, it is
interesting to note that phycocyanin was known to mediate the production of Reactive Oxygen Species (ROS) photodynamically to kill cancer cells (Lin et al. 2019).
Similarly, many cancer theranostics were patented applying PBPs (Table 24.6). It is
common to find the usage of bispecific antibodies which carry both the diagnostic
system and drug for treatment.
24.2.7 Human Cellular/Cell Subset Diagnostic Applications
It is vital to note that certain cellular and subcellular features could be diagnosed
using PBPs as markers. To cite, identification of antigen-specific T cells using
enzymatically biotinylated tetramers of major histocompatibility complex (MHC)
coupled with mutant streptavidin-phycoerythrin conjugate was made. Such T cells
find application as an essential tool in vaccine development, tumor immunology,
autoimmunity, etc. (Ramachandiran et al. 2007). Subset analysis of leukocyte of
new world monkeys was performed using the fluorochrome phycoerythrin (Brok
et al. 2001). Co-localization of subcellular molecular interaction of macromolecules
(like protein, transcription factor, DNA, etc.) using three-dimensional multi-color