18 Nutraceutical and Pharmaceutical Applications of Carotenoids
465
oils and fats on isomerization of (all-E)-lycopene. The European Journal of Lipid Science and
Technology, 119(1600389), 1–8.
Honda, M., Watanabe, Y., Murakami, K., Hoang, N.N., Wahyudiono, Kanda, H., & Goto, M.
(2018b). Enhanced lycopene extraction from gac (Momordica cochinchinensis Spreng.) by the
Z-Isomerization induced with microwave irradiation pre-treatment. The European Journal of
Lipid Science and Technology, 120(1700293), 1–8.
Honda, M., Watanabe, Y., Murakami, K., Takemura, R., Fukaya, T., Kanda, H., et al. (2017b).
Thermal isomerization pre-treatment to improve lycopene extraction from tomato pulp. LWT—
Food Science and Technology, 86, 69–75.
Hosokawa, M., Kudo, M., Maeda, H., Kohno, H., Tanaka, T., & Miyashita, K. (2004). Fucoxanthin
induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on
colon cancer cells. Biochimica et Biophysica Acta, 1675, 113–119.
Iwata, S., Imai, T., Shimazawa, M., Ishibashi, T., Hayashi, M., Hara, H., et al. (2018). Protective
effects of the astaxanthin derivative, adonixanthin, on brain hemorrhagic injury. Brain Research,
1698, 130–138.
Junghans, A., Sies, H., & Stahl, W. (2001). Macular pigments lutein and zeaxanthin as blue light
filters studied in liposomes. Archives of Biochemistry and Biophysics, 391, 160–164.
Kawee-ai, A., Kuntiya, A., & Kim, S. M. (2013). Anticholinesterase and antioxidant activities of fucoxanthin purified from the microalga Phaeodactylum tricornutum. Natural Products
Communications, 8, 1381–1386.
Khan, R. A., Elhassan, G. O., & Qureshi, K. A. (2014). Nutraceuticals: In the treatment & prevention
of diseases-an overview. Pharmaceutical Innovation, 3, 47–50.
Kidd, P. (2011). Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging
potential. Alternative Medicine Review, 16, 355–365.
Kijlstra, A., Tian, Y., Kelly, E. R., & Berendschot, T. T. (2012). Lutein: more than just a filter for
blue light. Progress in Retinal and Eye Research, 31, 303–315.
Kim, S., Ha, T. Y., & Hwang, I. K. (2009a). Analysis, bioavailability, and potential healthy effects
of capsanthin, natural red pigment from Capsicum spp. Food Reviews International, 25, 198–213.
Kim, Y. G., Lee, Y. H., Kang, M. K., Lee, B. H., Yun, J. K., Kim, S. B., et al. (2009b). Preparation
of functional cosmetics containing β-carotene derived from recombinant escherichia coli and
evaluation of anti-wrinkle efficacy by clinical testing. Microbiology and Biotechnology Letters,
37(4), 399–404.
Kodama, T., Honda, M., Takemura, R., Fukaya, T., Uemori, C., Kanda, H., et al. (2018). Effect of
the Z-isomer content on nanoparticle production of lycopene using solution-enhanced dispersion
by supercritical fluids (SEDS). Journal of Supercritical Fluids, 133, 291–296.
Köpcke, W., & Krutmann, J. (2008). Protection from sunburn with β-carotene—A meta-analysis.
Photochemistry and Photobiology, 84, 284–288.
Kowshik, J., Baba, A. B., Giri, H., Reddy, G. D., Dixit, M., & Nagini, S. (2014). Astaxanthin inhibits
JAK/STAT-3 signaling to abrogate cell proliferation, invasion and angiogenesis in a hamster model
of oral cancer. PLoS One, 9(e109114), 1–14.
Kuhad, A., Sethi, R., & Chopra, K. (2008). Lycopene attenuates diabetes-associated cognitive
decline in rats. Life Sciences, 83, 128–134.
Lavy, A., Amotz, A. B., & Aviram, M. (1993). Preferential inhibition of LDL oxidation by the
all-trans isomer of β-carotene in comparison with 9-cis β-carotene. Clinical Chemistry and
Laboratory Medicine, 31, 83–90.
Leoncini, E., Nedovic, D., Panic, N., Pastorino, R., Edefonti, V., & Boccia, S. (2015). Carotenoid
intake from natural sources and head and neck cancer: a systematic review and meta-analysis of
epidemiological studies. Cancer Epidemiology, Biomarkers & Prevention, 24, 1003–1011.
Levin, G., Yeshurun, M., & Mokady, S. (1997). In vivo antiperoxidative effect of 9-cis β-carotene
compared with that of the all-trans isomer. Nutrition and Cancer, 1997, 293–297.
Liu, X., & Osawa, T. (2007). Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher
antioxidant activity in vitro compared to the all-trans isomer. Biochemical and Biophysical
Research Communications, 357, 187–193.
465
oils and fats on isomerization of (all-E)-lycopene. The European Journal of Lipid Science and
Technology, 119(1600389), 1–8.
Honda, M., Watanabe, Y., Murakami, K., Hoang, N.N., Wahyudiono, Kanda, H., & Goto, M.
(2018b). Enhanced lycopene extraction from gac (Momordica cochinchinensis Spreng.) by the
Z-Isomerization induced with microwave irradiation pre-treatment. The European Journal of
Lipid Science and Technology, 120(1700293), 1–8.
Honda, M., Watanabe, Y., Murakami, K., Takemura, R., Fukaya, T., Kanda, H., et al. (2017b).
Thermal isomerization pre-treatment to improve lycopene extraction from tomato pulp. LWT—
Food Science and Technology, 86, 69–75.
Hosokawa, M., Kudo, M., Maeda, H., Kohno, H., Tanaka, T., & Miyashita, K. (2004). Fucoxanthin
induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on
colon cancer cells. Biochimica et Biophysica Acta, 1675, 113–119.
Iwata, S., Imai, T., Shimazawa, M., Ishibashi, T., Hayashi, M., Hara, H., et al. (2018). Protective
effects of the astaxanthin derivative, adonixanthin, on brain hemorrhagic injury. Brain Research,
1698, 130–138.
Junghans, A., Sies, H., & Stahl, W. (2001). Macular pigments lutein and zeaxanthin as blue light
filters studied in liposomes. Archives of Biochemistry and Biophysics, 391, 160–164.
Kawee-ai, A., Kuntiya, A., & Kim, S. M. (2013). Anticholinesterase and antioxidant activities of fucoxanthin purified from the microalga Phaeodactylum tricornutum. Natural Products
Communications, 8, 1381–1386.
Khan, R. A., Elhassan, G. O., & Qureshi, K. A. (2014). Nutraceuticals: In the treatment & prevention
of diseases-an overview. Pharmaceutical Innovation, 3, 47–50.
Kidd, P. (2011). Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging
potential. Alternative Medicine Review, 16, 355–365.
Kijlstra, A., Tian, Y., Kelly, E. R., & Berendschot, T. T. (2012). Lutein: more than just a filter for
blue light. Progress in Retinal and Eye Research, 31, 303–315.
Kim, S., Ha, T. Y., & Hwang, I. K. (2009a). Analysis, bioavailability, and potential healthy effects
of capsanthin, natural red pigment from Capsicum spp. Food Reviews International, 25, 198–213.
Kim, Y. G., Lee, Y. H., Kang, M. K., Lee, B. H., Yun, J. K., Kim, S. B., et al. (2009b). Preparation
of functional cosmetics containing β-carotene derived from recombinant escherichia coli and
evaluation of anti-wrinkle efficacy by clinical testing. Microbiology and Biotechnology Letters,
37(4), 399–404.
Kodama, T., Honda, M., Takemura, R., Fukaya, T., Uemori, C., Kanda, H., et al. (2018). Effect of
the Z-isomer content on nanoparticle production of lycopene using solution-enhanced dispersion
by supercritical fluids (SEDS). Journal of Supercritical Fluids, 133, 291–296.
Köpcke, W., & Krutmann, J. (2008). Protection from sunburn with β-carotene—A meta-analysis.
Photochemistry and Photobiology, 84, 284–288.
Kowshik, J., Baba, A. B., Giri, H., Reddy, G. D., Dixit, M., & Nagini, S. (2014). Astaxanthin inhibits
JAK/STAT-3 signaling to abrogate cell proliferation, invasion and angiogenesis in a hamster model
of oral cancer. PLoS One, 9(e109114), 1–14.
Kuhad, A., Sethi, R., & Chopra, K. (2008). Lycopene attenuates diabetes-associated cognitive
decline in rats. Life Sciences, 83, 128–134.
Lavy, A., Amotz, A. B., & Aviram, M. (1993). Preferential inhibition of LDL oxidation by the
all-trans isomer of β-carotene in comparison with 9-cis β-carotene. Clinical Chemistry and
Laboratory Medicine, 31, 83–90.
Leoncini, E., Nedovic, D., Panic, N., Pastorino, R., Edefonti, V., & Boccia, S. (2015). Carotenoid
intake from natural sources and head and neck cancer: a systematic review and meta-analysis of
epidemiological studies. Cancer Epidemiology, Biomarkers & Prevention, 24, 1003–1011.
Levin, G., Yeshurun, M., & Mokady, S. (1997). In vivo antiperoxidative effect of 9-cis β-carotene
compared with that of the all-trans isomer. Nutrition and Cancer, 1997, 293–297.
Liu, X., & Osawa, T. (2007). Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher
antioxidant activity in vitro compared to the all-trans isomer. Biochemical and Biophysical
Research Communications, 357, 187–193.