200
M. R. Nikolic et al.
chromophore of blue-green alga Spirulina: Molecular dynamics and experimental Study. PLoS
ONE, 11, e0167973.
Rahman, D. Y., Sarian, F. D., van Wijk, A., Martinez-Garcia, M., & van der Maarel, M. J. E.
C. (2017). Thermostable phycocyanin from the red microalga Cyanidioschyzon merolae, a new
natural blue food colorant. Journal of Applied Phycology, 29, 1233–1239.
Ravi, M., Tentu, S., Baskar, G., Rohan Prasad, S., Raghavan, S., Jayaprakash, P., et al. (2015).
Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer
cells. BMC Cancer, 15, 768.
Rimbau, V., Camins, A., Romay, C., González, R., & Pallàs, M. (1999). Protective effects of Cphycocyanin against kainic acid-induced neuronal damage in rat hippocampus. Neuroscience
Letters, 276, 75–78.
Riss, J., Décordé, K., Sutra, T., Delage, M., Baccou, J. C., Jouy, N., et al. (2007). Phycobiliprotein Cphycocyanin from Spirulina platensis is powerfully responsible for reducing oxidative stress and
NADPH oxidase expression induced by an atherogenic diet in hamsters. Journal of Agriculture
and Food Chemistry, 55, 7962–7967.
Roda-Serrat, M. C., Christensen, K. V., El-Houri, R. B., Frette, X., & Christensen, L. P. (2018).
Fast cleavage of phycocyanobilin from phycocyanin for use in food colouring. Food Chemistry,
240, 655–661.
Sampath-Wiley, P., & Neefus, C. (2007). An improved method for estimating R-phycoerythrin
and R-phycocyanin contents from crude aqueous extracts of Porphyra (Bangiales, Rhodophyta).
Journal of Applied Phycology, 19, 123–129.
Sathyasaikumar, K. V., Swapna, I., Reddy, P. V., Murthy, Ch R, Roy, K. R., Dutta Gupta, A.,
et al. (2007). Co-administration of C-phycocyanin ameliorates thioacetamide-induced hepatic
encephalopathy in Wistar rats. Journal of the Neurological Sciences, 252, 67–75.
Sepúlveda-Ugarte, J., Brunet, J. E., Matamala, A. R., Martínez-Oyanedel, J., & Bunster, M.
(2011). Spectroscopic parameters of phycoerythrobilin and phycourobilin on phycoerythrin from
Gracilaria chilensis. Journal of Photochemistry and Photobiology A: Chemistry, 219, 211–216.
Sheu, M. J., Hsieh, Y. Y., Lai, C. H., Chang, C. C., & Wu, C. H. (2013). Antihyperlipidemic and
antioxidant effects of C-phycocyanin in Golden Syrian hamsters fed with a hypercholesterolemic
diet. Journal of Traditional and Complementary Medicine, 3, 41–47.
Shi, J., Chen, Y., Xu, Y., Ji, D., Chen, C., & Xie, C. (2017). Differential proteomic analysis by
iTRAQ reveals the mechanism of Pyropia haitanensis responding to high temperature stress.
Scientific Reports, 7, 44734.
Singh, P., Kuddus, M., & Thomas, G. (2011). Isolation and binding affinity of C-phycocyanin to
blood cells and genomic DNA as well as its diagnostic applications. Journal of Biotechnology
and Pharmaceutical Research, 2, 001–008.
Sonani, R. R., Singh, N. K., Awasthi, A., Prasad, B., Kumar, J., & Madamwar, D. (2014a).
Phycoerythrin extends life span and health span of Caenorhabditis elegans. Age (Dordr), 36,
9717.
Sonani, R. R., Singh, N. K., Kumar, J., Thakar, D., & Madamwar, D. (2014b). Concurrent purification
and antioxidant activity of phycobiliproteins from Lyngbya sp. A09DM: An antioxidant and antiaging potential of phycoerythrin in Caenorhabditis elegans. Process Biochemistry, 49, 1757–1766.
Sonani, R. R., Rastogi, R. P., Patel, R., & Madamwar, D. (2016). Recent advances in production,
purification and applications of phycobiliproteins. World Journal of Biological Chemistry, 7,
100–109.
Spat, P., Klotz, A., Rexroth, S., Macek, B., & Forchhammer, K. (2018). Chlorosis as a developmental
program in cyanobacteria: The proteomic fundament for survival and awakening. Molecular and
Cellular Proteomics, 17, 1650–1669.
Stanic-Vucinic, D., Minic, S., Nikolic, M. R., & Cirkovic Velickovic, T. (2018). Spirulina phycobiliproteins as food components and complements. In: E. Jacob-Lopes, L. Q. Zepka, M. I. Queiroz
(Eds.), Microalgal biotechnology (pp. 129–149). IntechOpen.
M. R. Nikolic et al.
chromophore of blue-green alga Spirulina: Molecular dynamics and experimental Study. PLoS
ONE, 11, e0167973.
Rahman, D. Y., Sarian, F. D., van Wijk, A., Martinez-Garcia, M., & van der Maarel, M. J. E.
C. (2017). Thermostable phycocyanin from the red microalga Cyanidioschyzon merolae, a new
natural blue food colorant. Journal of Applied Phycology, 29, 1233–1239.
Ravi, M., Tentu, S., Baskar, G., Rohan Prasad, S., Raghavan, S., Jayaprakash, P., et al. (2015).
Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer
cells. BMC Cancer, 15, 768.
Rimbau, V., Camins, A., Romay, C., González, R., & Pallàs, M. (1999). Protective effects of Cphycocyanin against kainic acid-induced neuronal damage in rat hippocampus. Neuroscience
Letters, 276, 75–78.
Riss, J., Décordé, K., Sutra, T., Delage, M., Baccou, J. C., Jouy, N., et al. (2007). Phycobiliprotein Cphycocyanin from Spirulina platensis is powerfully responsible for reducing oxidative stress and
NADPH oxidase expression induced by an atherogenic diet in hamsters. Journal of Agriculture
and Food Chemistry, 55, 7962–7967.
Roda-Serrat, M. C., Christensen, K. V., El-Houri, R. B., Frette, X., & Christensen, L. P. (2018).
Fast cleavage of phycocyanobilin from phycocyanin for use in food colouring. Food Chemistry,
240, 655–661.
Sampath-Wiley, P., & Neefus, C. (2007). An improved method for estimating R-phycoerythrin
and R-phycocyanin contents from crude aqueous extracts of Porphyra (Bangiales, Rhodophyta).
Journal of Applied Phycology, 19, 123–129.
Sathyasaikumar, K. V., Swapna, I., Reddy, P. V., Murthy, Ch R, Roy, K. R., Dutta Gupta, A.,
et al. (2007). Co-administration of C-phycocyanin ameliorates thioacetamide-induced hepatic
encephalopathy in Wistar rats. Journal of the Neurological Sciences, 252, 67–75.
Sepúlveda-Ugarte, J., Brunet, J. E., Matamala, A. R., Martínez-Oyanedel, J., & Bunster, M.
(2011). Spectroscopic parameters of phycoerythrobilin and phycourobilin on phycoerythrin from
Gracilaria chilensis. Journal of Photochemistry and Photobiology A: Chemistry, 219, 211–216.
Sheu, M. J., Hsieh, Y. Y., Lai, C. H., Chang, C. C., & Wu, C. H. (2013). Antihyperlipidemic and
antioxidant effects of C-phycocyanin in Golden Syrian hamsters fed with a hypercholesterolemic
diet. Journal of Traditional and Complementary Medicine, 3, 41–47.
Shi, J., Chen, Y., Xu, Y., Ji, D., Chen, C., & Xie, C. (2017). Differential proteomic analysis by
iTRAQ reveals the mechanism of Pyropia haitanensis responding to high temperature stress.
Scientific Reports, 7, 44734.
Singh, P., Kuddus, M., & Thomas, G. (2011). Isolation and binding affinity of C-phycocyanin to
blood cells and genomic DNA as well as its diagnostic applications. Journal of Biotechnology
and Pharmaceutical Research, 2, 001–008.
Sonani, R. R., Singh, N. K., Awasthi, A., Prasad, B., Kumar, J., & Madamwar, D. (2014a).
Phycoerythrin extends life span and health span of Caenorhabditis elegans. Age (Dordr), 36,
9717.
Sonani, R. R., Singh, N. K., Kumar, J., Thakar, D., & Madamwar, D. (2014b). Concurrent purification
and antioxidant activity of phycobiliproteins from Lyngbya sp. A09DM: An antioxidant and antiaging potential of phycoerythrin in Caenorhabditis elegans. Process Biochemistry, 49, 1757–1766.
Sonani, R. R., Rastogi, R. P., Patel, R., & Madamwar, D. (2016). Recent advances in production,
purification and applications of phycobiliproteins. World Journal of Biological Chemistry, 7,
100–109.
Spat, P., Klotz, A., Rexroth, S., Macek, B., & Forchhammer, K. (2018). Chlorosis as a developmental
program in cyanobacteria: The proteomic fundament for survival and awakening. Molecular and
Cellular Proteomics, 17, 1650–1669.
Stanic-Vucinic, D., Minic, S., Nikolic, M. R., & Cirkovic Velickovic, T. (2018). Spirulina phycobiliproteins as food components and complements. In: E. Jacob-Lopes, L. Q. Zepka, M. I. Queiroz
(Eds.), Microalgal biotechnology (pp. 129–149). IntechOpen.