WW (2008) Loss of singleminded-2s in the
mouse mammary gland induces an epithelialmesenchymal transition associated with
up-regulation of slug and matrix metalloprotease 2. Mol Cell Biol 28(6):1936–1946.
https://doi.org/10.1128/MCB.01701-07
86. Acloque H, Ocana OH, Matheu A, Rizzoti K,
Wise C, Lovell-Badge R, Nieto MA (2011)
Reciprocal repression between Sox3 and snail
transcription factors defines embryonic territories at gastrulation. Dev Cell 21
(3):546–558.
https://doi.org/10.1016/j.
devcel.2011.07.005
87. Barrallo-Gimeno A, Nieto MA (2005) The
snail genes as inducers of cell movement and
survival: implications in development and
cancer. Development 132(14):3151–3161.
https://doi.org/10.1242/dev.01907
88. Traylor-Knowles N, Hansen U, Dubuc TQ,
Martindale MQ, Kaufman L, Finnerty JR
(2010) The evolutionary diversification of
LSF and Grainyhead transcription factors preceded the radiation of basal animal lineages.
BMC Evol Biol 10:101. https://doi.org/10.
1186/1471-2148-10-101
89. Barrallo-Gimeno A, Nieto MA (2009) Evolutionary history of the snail/scratch superfamily. Trends Genet 25(6):248–252. https://
doi.org/10.1016/j.tig.2009.04.001
90. Pattabiraman DR, Bierie B, Kober KI,
Thiru P, Krall JA, Zill C, Reinhardt F, Tam
WL, Weinberg RA (2016) Activation of PKA
leads to mesenchymal-to-epithelial transition
and loss of tumor-initiating ability. Science
351(6277):aad3680.
https://doi.org/10.
1126/science.aad3680
91. Park SM, Gaur AB, Lengyel E, Peter ME
(2008) The miR-200 family determines the
epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and
ZEB2. Genes Dev 22(7):894–907. https://
doi.org/10.1101/gad.1640608
92. Gregory PA, Bert AG, Paterson EL, Barry SC,
Tsykin A, Farshid G, Vadas MA, KhewGoodall Y, Goodall GJ (2008) The miR-200
family and miR-205 regulate epithelial to
mesenchymal transition by targeting ZEB1
and SIP1. Nat Cell Biol 10(5):593–601.
https://doi.org/10.1038/ncb1722
93. Bracken CP, Gregory PA, Kolesnikoff N, Bert
AG, Wang J, Shannon MF, Goodall GJ
(2008) A double-negative feedback loop
between ZEB1-SIP1 and the microRNA200 family regulates epithelial-mesenchymal
transition. Cancer Res 68(19):7846–7854.
https://doi.org/10.1158/0008-5472.CAN08-1942
94. Burk U, Schubert J, Wellner U,
Schmalhofer O, Vincan E, Spaderna S, Brabletz T (2008) A reciprocal repression
between ZEB1 and members of the
miR-200 family promotes EMT and invasion
in cancer cells. EMBO Rep 9(6):582–589.
https://doi.org/10.1038/embor.2008.74
95. Abba ML, Patil N, Leupold JH, Allgayer H
(2016) MicroRNA regulation of epithelial to
mesenchymal transition. J Clin Med 5(1).
https://doi.org/10.3390/jcm5010008
96. Zhou BP, Deng J, Xia W, Xu J, Li YM,
Gunduz M, Hung MC (2004) Dual regulation of snail by GSK-3beta-mediated phosphorylation in control of epithelialmesenchymal transition. Nat Cell Biol 6
(10):931–940.
https://doi.org/10.1038/
ncb1173
97. Peinado H, Del Carmen Iglesias-de la
Cruz M, Olmeda D, Csiszar K, Fong KS,
Vega S, Nieto MA, Cano A, Portillo F
(2005) A molecular role for lysyl oxidase-like
2 enzyme in snail regulation and tumor progression. EMBO J 24(19):3446–3458.
https://doi.org/10.1038/sj.emboj.
7600781
98. Jung HY, Fattet L, Tsai JH, Kajimoto T,
Chang Q, Newton AC, Yang J (2019)
Apical-basal polarity inhibits epithelialmesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nat Cell Biol 21(3):359–371.
https://doi.org/10.1038/s41556-0190291-8
99. Weng M, Wieschaus E (2016) Myosindependent remodeling of adherens junctions
protects junctions from snail-dependent disassembly. J Cell Biol 212(2):219–229.
https://doi.org/10.1083/jcb.201508056
100. Campbell K, Casanova J, Skaer H (2010)
Mesenchymal-to-epithelial transition of intercalating cells in drosophila renal tubules
depends on polarity cues from epithelial
neighbours. Mech Dev 127(7-8):345–357.
https://doi.org/10.1016/j.mod.2010.04.
002
101. Nagafuchi A, Shirayoshi Y, Okazaki K,
Yasuda K, Takeichi M (1987) Transformation
of cell adhesion properties by exogenously
introduced E-cadherin cDNA. Nature 329
(6137):341–343. https://doi.org/10.1038/
329341a0
102. Mege RM, Matsuzaki F, Gallin WJ, Goldberg
JI, Cunningham BA, Edelman GM (1988)
Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs
for chicken cell adhesion molecules. Proc Natl
Mechanisms of MET in Development and Cancer
61
mouse mammary gland induces an epithelialmesenchymal transition associated with
up-regulation of slug and matrix metalloprotease 2. Mol Cell Biol 28(6):1936–1946.
https://doi.org/10.1128/MCB.01701-07
86. Acloque H, Ocana OH, Matheu A, Rizzoti K,
Wise C, Lovell-Badge R, Nieto MA (2011)
Reciprocal repression between Sox3 and snail
transcription factors defines embryonic territories at gastrulation. Dev Cell 21
(3):546–558.
https://doi.org/10.1016/j.
devcel.2011.07.005
87. Barrallo-Gimeno A, Nieto MA (2005) The
snail genes as inducers of cell movement and
survival: implications in development and
cancer. Development 132(14):3151–3161.
https://doi.org/10.1242/dev.01907
88. Traylor-Knowles N, Hansen U, Dubuc TQ,
Martindale MQ, Kaufman L, Finnerty JR
(2010) The evolutionary diversification of
LSF and Grainyhead transcription factors preceded the radiation of basal animal lineages.
BMC Evol Biol 10:101. https://doi.org/10.
1186/1471-2148-10-101
89. Barrallo-Gimeno A, Nieto MA (2009) Evolutionary history of the snail/scratch superfamily. Trends Genet 25(6):248–252. https://
doi.org/10.1016/j.tig.2009.04.001
90. Pattabiraman DR, Bierie B, Kober KI,
Thiru P, Krall JA, Zill C, Reinhardt F, Tam
WL, Weinberg RA (2016) Activation of PKA
leads to mesenchymal-to-epithelial transition
and loss of tumor-initiating ability. Science
351(6277):aad3680.
https://doi.org/10.
1126/science.aad3680
91. Park SM, Gaur AB, Lengyel E, Peter ME
(2008) The miR-200 family determines the
epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and
ZEB2. Genes Dev 22(7):894–907. https://
doi.org/10.1101/gad.1640608
92. Gregory PA, Bert AG, Paterson EL, Barry SC,
Tsykin A, Farshid G, Vadas MA, KhewGoodall Y, Goodall GJ (2008) The miR-200
family and miR-205 regulate epithelial to
mesenchymal transition by targeting ZEB1
and SIP1. Nat Cell Biol 10(5):593–601.
https://doi.org/10.1038/ncb1722
93. Bracken CP, Gregory PA, Kolesnikoff N, Bert
AG, Wang J, Shannon MF, Goodall GJ
(2008) A double-negative feedback loop
between ZEB1-SIP1 and the microRNA200 family regulates epithelial-mesenchymal
transition. Cancer Res 68(19):7846–7854.
https://doi.org/10.1158/0008-5472.CAN08-1942
94. Burk U, Schubert J, Wellner U,
Schmalhofer O, Vincan E, Spaderna S, Brabletz T (2008) A reciprocal repression
between ZEB1 and members of the
miR-200 family promotes EMT and invasion
in cancer cells. EMBO Rep 9(6):582–589.
https://doi.org/10.1038/embor.2008.74
95. Abba ML, Patil N, Leupold JH, Allgayer H
(2016) MicroRNA regulation of epithelial to
mesenchymal transition. J Clin Med 5(1).
https://doi.org/10.3390/jcm5010008
96. Zhou BP, Deng J, Xia W, Xu J, Li YM,
Gunduz M, Hung MC (2004) Dual regulation of snail by GSK-3beta-mediated phosphorylation in control of epithelialmesenchymal transition. Nat Cell Biol 6
(10):931–940.
https://doi.org/10.1038/
ncb1173
97. Peinado H, Del Carmen Iglesias-de la
Cruz M, Olmeda D, Csiszar K, Fong KS,
Vega S, Nieto MA, Cano A, Portillo F
(2005) A molecular role for lysyl oxidase-like
2 enzyme in snail regulation and tumor progression. EMBO J 24(19):3446–3458.
https://doi.org/10.1038/sj.emboj.
7600781
98. Jung HY, Fattet L, Tsai JH, Kajimoto T,
Chang Q, Newton AC, Yang J (2019)
Apical-basal polarity inhibits epithelialmesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nat Cell Biol 21(3):359–371.
https://doi.org/10.1038/s41556-0190291-8
99. Weng M, Wieschaus E (2016) Myosindependent remodeling of adherens junctions
protects junctions from snail-dependent disassembly. J Cell Biol 212(2):219–229.
https://doi.org/10.1083/jcb.201508056
100. Campbell K, Casanova J, Skaer H (2010)
Mesenchymal-to-epithelial transition of intercalating cells in drosophila renal tubules
depends on polarity cues from epithelial
neighbours. Mech Dev 127(7-8):345–357.
https://doi.org/10.1016/j.mod.2010.04.
002
101. Nagafuchi A, Shirayoshi Y, Okazaki K,
Yasuda K, Takeichi M (1987) Transformation
of cell adhesion properties by exogenously
introduced E-cadherin cDNA. Nature 329
(6137):341–343. https://doi.org/10.1038/
329341a0
102. Mege RM, Matsuzaki F, Gallin WJ, Goldberg
JI, Cunningham BA, Edelman GM (1988)
Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs
for chicken cell adhesion molecules. Proc Natl
Mechanisms of MET in Development and Cancer
61