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1016/j.celrep.2018.07.026
112. Downing TL, Soto J, Morez C, Houssin T,
Fritz A, Yuan F, Chu J, Patel S, Schaffer DV,
Li S (2013) Biophysical regulation of epigenetic state and cell reprogramming. Nat
Mater 12(12):1154–1162. https://doi.org/
10.1038/nmat3777
113. Fatehullah A, Tan SH, Barker N (2016)
Organoids as an in vitro model of human
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https://doi.org/10.1038/
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114. Shaw TJ, Martin P (2016) Wound repair: a
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org/10.1016/j.ceb.2016.04.001
62
John-Poul Ng-Blichfeldt and Katja Ro ¨ per
doi.org/10.1073/pnas.85.19.7274
103. Auersperg N, Pan J, Grove BD, Peterson T,
Fisher J, Maines-Bandiera S, Somasiri A, Roskelley CD (1999) E-cadherin induces
mesenchymal-to-epithelial
transition
in
human ovarian surface epithelium. Proc Natl
Acad Sci U S A 96(11):6249–6254. https://
doi.org/10.1073/pnas.96.11.6249
104. McCrea PD, Gottardi CJ (2016) Beyond
beta-catenin: prospects for a larger catenin
network in the nucleus. Nat Rev Mol Cell
Biol
17(1):55–64.
https://doi.org/10.
1038/nrm.2015.3
105. Conacci-Sorrell M, Simcha I, Ben-Yedidia T,
Blechman J, Savagner P, Ben-Ze’ev A (2003)
Autoregulation of E-cadherin expression by
cadherin-cadherin interactions: the roles of
beta-catenin signaling, slug, and MAPK. J
Cell Biol 163(4):847–857. https://doi.org/
10.1083/jcb.200308162
106. Pece S, Gutkind JS (2000) Signaling from
E-cadherins to the MAPK pathway by the
recruitment and activation of epidermal
growth factor receptors upon cell-cell contact
formation.
J
Biol
Chem
275
(52):41227–41233.
https://doi.org/10.
1074/jbc.M006578200
107. Rubsam M, Mertz AF, Kubo A, Marg S,
Jungst C, Goranci-Buzhala G, Schauss AC,
Horsley V, Dufresne ER, Moser M,
Ziegler W, Amagai M, Wickstrom SA, Niessen
CM (2017) E-cadherin integrates mechanotransduction and EGFR signaling to control
junctional tissue polarization and tight junction positioning. Nat Commun 8(1):1250.
https://doi.org/10.1038/s41467-01701170-7
108. Li R, Liang J, Ni S, Zhou T, Qing X, Li H,
He W, Chen J, Li F, Zhuang Q, Qin B, Xu J,
Li W, Yang J, Gan Y, Qin D, Feng S, Song H,
Yang D, Zhang B, Zeng L, Lai L, Esteban
MA, Pei D (2010) A mesenchymal-to-epithelial transition initiates and is required for the
nuclear reprogramming of mouse fibroblasts.
Cell Stem Cell 7(1):51–63. https://doi.org/
10.1016/j.stem.2010.04.014
109. Samavarchi-Tehrani P, Golipour A, David L,
Sung HK, Beyer TA, Datti A, Woltjen K,
Nagy A, Wrana JL (2010) Functional genomics reveals a BMP-driven mesenchymal-toepithelial transition in the initiation of
somatic cell reprogramming. Cell Stem Cell
7(1):64–77.
https://doi.org/10.1016/j.
stem.2010.04.015
110. Li Q, Hutchins AP, Chen Y, Li S, Shan Y,
Liao B, Zheng D, Shi X, Li Y, Chan WY,
Pan G, Wei S, Shu X, Pei D (2017) A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells
towards
hepatocytes.
Nat
Commun
8:15166.
https://doi.org/10.1038/
ncomms15166
111. Ward C, Volpe G, Cauchy P, Ptasinska A,
Almaghrabi R, Blakemore D, Nafria M,
Kestner D, Frampton J, Murphy G,
Buganim Y, Kaji K, Garcia P (2018) Finetuning Mybl2 is required for proper
mesenchymal-to-epithelial transition during
somatic reprogramming. Cell Rep 24
(6):1496–1511. e1498. https://doi.org/10.
1016/j.celrep.2018.07.026
112. Downing TL, Soto J, Morez C, Houssin T,
Fritz A, Yuan F, Chu J, Patel S, Schaffer DV,
Li S (2013) Biophysical regulation of epigenetic state and cell reprogramming. Nat
Mater 12(12):1154–1162. https://doi.org/
10.1038/nmat3777
113. Fatehullah A, Tan SH, Barker N (2016)
Organoids as an in vitro model of human
development and disease. Nat Cell Biol 18
(3):246–254.
https://doi.org/10.1038/
ncb3312
114. Shaw TJ, Martin P (2016) Wound repair: a
showcase for cell plasticity and migration.
Curr Opin Cell Biol 42:29–37. https://doi.
org/10.1016/j.ceb.2016.04.001
62
John-Poul Ng-Blichfeldt and Katja Ro ¨ per