62. Mudimu O, Rybalka N, Bauersachs T, Born J, Friedl T, Schulz R (2014) Biotechnological
screening of microalgal and cyanobacterial strains for biogas production and antibacterial and
antifungal effects. Metsbolites 4(2):373–393
63. Santoyo S, Rodríguez-Meizoso I, Cifuentes A, Jaime L, Reina GG, Señorans FJ, Ibáñez E
(2009) Green processes based on the extraction with pressurized fluids to obtain potent
antimicrobials from Haematococcus pluvialis microalgae. LWT-Food Sci Technol 42
(7):1213–1218
64. Abedin RM, Taha HM (2008) Antibacterial and antifungal activity of cyanobacteria and green
microalgae. Evaluation of medium components by Plackett-Burman design for antimicrobial
activity of Spirulina platensis. Global J Biotechnol Biochem 3(1):22–31
65. Najdenski HM, Gigova LG, Iliev II, Pilarski PS, Lukavský J, Tsvetkova IV, Ninova MS,
Kussovski VK (2013) Antibacterial and antifungal activities of selected microalgae and
cyanobacteria. Int J Food Sci Technol 48(7):1533–1540
66. Samarakoon KW, Ko JY, Lee JH, Kwon ON, Kim SW, Jeon YJ (2014) Apoptotic anticancer
activity of a novel fatty alcohol ester isolated from cultured marine diatom, Phaeodactylum
tricornutum. J Funct Foods 6:231–240
67. Sansone C, Braca A, Ercolesi E, Romano G, Palumbo A, Casotti R, Francone M, Ianora A
(2014) Diatom-derived polyunsaturated aldehydes activate cell death in human cancer cell lines
but not normal cells. PLoS One 9(7):e101220
68. Liu J, Sun Z, Gerken H, Liu Z, Jiang Y, Chen F (2014) Chlorella zofingiensis as an alternative
microalgal producer of astaxanthin: biology and industrial potential. Mar Drugs 12
(6):3487–3515
69. Kim Y, Seo JH, Kim H (2011) β-Carotene and lutein inhibit hydrogen peroxide-induced
activation of NF-κB and IL-8 expression in gastric epithelial AGS cells. J Nutr Sci Vitaminol
57(3):216–223
70. Davidi L, Shimoni E, Khozin-Goldberg I, Zamir A, Pick U (2014) Origin of β-carotene-rich
plastoglobuli in Dunaliella bardawil. Plant Physiol 164(4):2139–2156
71. Maeda N, Kokai Y, Ohtani S, Sahara H, Kumamoto-Yonezawa Y, Kuriyama I, Hada T, Sato N,
Yoshida H, Mizushina Y (2008) Anti-tumor effect of orally administered spinach glycolipid
fraction on implanted cancer cells, colon-26, in mice. Lipids 43(8):741
72. Hossain Z, Kurihara H, Hosokawa M, Takahashi K (2005) Growth inhibition and induction of
differentiation and apoptosis mediated by sodium butyrate in Caco-2 cells with algal glycolipids. In Vitro Cell Dev Biol Anim 41(5–6):154–159
73. Guzman S, Gato A, Lamela M, Freire-Garabal M, Calleja JM (2003) Anti-inflammatory and
immunomodulatory activities of polysaccharide from Chlorella stigmatophora and
Phaeodactylum tricornutum. Phytother Res 17(6):665–670
74. Nomoto K, Yokokura T, Satoh H, Mutai M (1983) Antitumor activity of chlorella extract,
PCM-4, by oral administration. Gan To Kagaku Ryoho 10(3):781–785
75. Sadovskaya I, Souissi A, Souissi S, Grard T, Lencel P, Greene CM, Duin S, Dmitrenok PS,
Chizhov AO, Shashkov AS, Usov AI (2014) Chemical structure and biological activity of a
highly branched (1! 3, 1! 6)-β-d-glucan from Isochrysis galbana. Carbohydr Polym
111:139–148
76. Matsui MS, Muizzuddin N, Arad S, Marenus K (2003) Sulfated polysaccharides from red
microalgae have antiinflammatory properties in vitro and in vivo. Appl Biochem Biotechnol
104(1):13–22
77. Bae SY, Yim JH, Lee HK, Pyo S (2006) Activation of murine peritoneal macrophages by
sulfated exopolysaccharide from marine microalga Gyrodinium impudicum (strain KG03):
involvement of the NF-κB and JNK pathway. Int Immunopharmacol 6(3):473–484
78. Challouf R, Trabelsi L, Ben Dhieb R, El Abed O, Yahia A, Ghozzi K, Ben Ammar J, Omran H,
Ben OH (2011) Evaluation of cytotoxicity and biological activities in extracellular polysaccharides released by cyanobacterium Arthrospira platensis. Braz Arch Biol Technol 54(4):831–838
79. Romay CH, Gonzalez R, Ledon N, Remirez D, Rimbau V (2003) C-phycocyanin: a biliprotein
with antioxidant, anti-inflammatory and neuroprotective effects. Curr Protein Pept Sci 4
(3):207–216
Applications and Efficacy of Exceptional Bioactive Compounds from Microalgae
175
screening of microalgal and cyanobacterial strains for biogas production and antibacterial and
antifungal effects. Metsbolites 4(2):373–393
63. Santoyo S, Rodríguez-Meizoso I, Cifuentes A, Jaime L, Reina GG, Señorans FJ, Ibáñez E
(2009) Green processes based on the extraction with pressurized fluids to obtain potent
antimicrobials from Haematococcus pluvialis microalgae. LWT-Food Sci Technol 42
(7):1213–1218
64. Abedin RM, Taha HM (2008) Antibacterial and antifungal activity of cyanobacteria and green
microalgae. Evaluation of medium components by Plackett-Burman design for antimicrobial
activity of Spirulina platensis. Global J Biotechnol Biochem 3(1):22–31
65. Najdenski HM, Gigova LG, Iliev II, Pilarski PS, Lukavský J, Tsvetkova IV, Ninova MS,
Kussovski VK (2013) Antibacterial and antifungal activities of selected microalgae and
cyanobacteria. Int J Food Sci Technol 48(7):1533–1540
66. Samarakoon KW, Ko JY, Lee JH, Kwon ON, Kim SW, Jeon YJ (2014) Apoptotic anticancer
activity of a novel fatty alcohol ester isolated from cultured marine diatom, Phaeodactylum
tricornutum. J Funct Foods 6:231–240
67. Sansone C, Braca A, Ercolesi E, Romano G, Palumbo A, Casotti R, Francone M, Ianora A
(2014) Diatom-derived polyunsaturated aldehydes activate cell death in human cancer cell lines
but not normal cells. PLoS One 9(7):e101220
68. Liu J, Sun Z, Gerken H, Liu Z, Jiang Y, Chen F (2014) Chlorella zofingiensis as an alternative
microalgal producer of astaxanthin: biology and industrial potential. Mar Drugs 12
(6):3487–3515
69. Kim Y, Seo JH, Kim H (2011) β-Carotene and lutein inhibit hydrogen peroxide-induced
activation of NF-κB and IL-8 expression in gastric epithelial AGS cells. J Nutr Sci Vitaminol
57(3):216–223
70. Davidi L, Shimoni E, Khozin-Goldberg I, Zamir A, Pick U (2014) Origin of β-carotene-rich
plastoglobuli in Dunaliella bardawil. Plant Physiol 164(4):2139–2156
71. Maeda N, Kokai Y, Ohtani S, Sahara H, Kumamoto-Yonezawa Y, Kuriyama I, Hada T, Sato N,
Yoshida H, Mizushina Y (2008) Anti-tumor effect of orally administered spinach glycolipid
fraction on implanted cancer cells, colon-26, in mice. Lipids 43(8):741
72. Hossain Z, Kurihara H, Hosokawa M, Takahashi K (2005) Growth inhibition and induction of
differentiation and apoptosis mediated by sodium butyrate in Caco-2 cells with algal glycolipids. In Vitro Cell Dev Biol Anim 41(5–6):154–159
73. Guzman S, Gato A, Lamela M, Freire-Garabal M, Calleja JM (2003) Anti-inflammatory and
immunomodulatory activities of polysaccharide from Chlorella stigmatophora and
Phaeodactylum tricornutum. Phytother Res 17(6):665–670
74. Nomoto K, Yokokura T, Satoh H, Mutai M (1983) Antitumor activity of chlorella extract,
PCM-4, by oral administration. Gan To Kagaku Ryoho 10(3):781–785
75. Sadovskaya I, Souissi A, Souissi S, Grard T, Lencel P, Greene CM, Duin S, Dmitrenok PS,
Chizhov AO, Shashkov AS, Usov AI (2014) Chemical structure and biological activity of a
highly branched (1! 3, 1! 6)-β-d-glucan from Isochrysis galbana. Carbohydr Polym
111:139–148
76. Matsui MS, Muizzuddin N, Arad S, Marenus K (2003) Sulfated polysaccharides from red
microalgae have antiinflammatory properties in vitro and in vivo. Appl Biochem Biotechnol
104(1):13–22
77. Bae SY, Yim JH, Lee HK, Pyo S (2006) Activation of murine peritoneal macrophages by
sulfated exopolysaccharide from marine microalga Gyrodinium impudicum (strain KG03):
involvement of the NF-κB and JNK pathway. Int Immunopharmacol 6(3):473–484
78. Challouf R, Trabelsi L, Ben Dhieb R, El Abed O, Yahia A, Ghozzi K, Ben Ammar J, Omran H,
Ben OH (2011) Evaluation of cytotoxicity and biological activities in extracellular polysaccharides released by cyanobacterium Arthrospira platensis. Braz Arch Biol Technol 54(4):831–838
79. Romay CH, Gonzalez R, Ledon N, Remirez D, Rimbau V (2003) C-phycocyanin: a biliprotein
with antioxidant, anti-inflammatory and neuroprotective effects. Curr Protein Pept Sci 4
(3):207–216
Applications and Efficacy of Exceptional Bioactive Compounds from Microalgae
175