44. Manirafasha E, Ndikubwimana T, Zeng X, Lu Y, Jing K (2016) Phycobiliprotein: potential
microalgae derived pharmaceutical and biological reagent. Biochem Eng J 109:282–296
45. Talero E, García-Mauriño S, Ávila-Román J, Rodríguez-Luna A, Alcaide A, Motilva V (2015)
Bioactive compounds isolated from microalgae in chronic inflammation and cancer. Mar Drugs
13(10):6152–6209
46. Bleakley S, Hayes M (2017) Algal proteins: extraction, application, and challenges concerning
production. Foods 6(5):33
47. Manzo E, Ciavatta ML, Bakkas S, Villani G, Varcamonti M, Zanfardino A, Gavagnin M (2009)
Diterpene content of the alga Dictyota ciliolata from a Moroccan lagoon. Phytochem Lett 2
(4):211–215
48. Pereira H, Leão-Ferreira LR, Moussatché N, Teixeira VL, Cavalcanti DN, Costa LJ, Diaz R,
Frugulhetti IC (2004) Antiviral activity of diterpenes isolated from the Brazilian marine alga
Dictyota menstrualis against human immunodeficiency virus type 1 (HIV-1). Antiviral Res 64
(1):69–76
49. Lee JB, Hayashi K, Hirata M, Kuroda E, Suzuki E, Kubo Y, Hayashi T (2006) Antiviral sulfated
polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay.
Biol Pharm Bull 29(10):2135–2139
50. Gastineau R, Turcotte F, Pouvreau JB, Morançais M, Fleurence J, Windarto E, Prasetiya F,
Arsad S, Jaouen P, Babin M, Coiffard L (2014) Marennine, promising blue pigments from a
widespread Haslea diatom species complex. Mar Drugs 12(6):3161–3189
51. Yim JH, Kim SJ, Ahn SH, Lee CK, Rhie KT, Lee HK (2004) Antiviral effects of sulfated
exopolysaccharide from the marine microalga Gyrodinium impudicum strain KG03. Marine
Biotechnol 6(1):17–25
52. Elkomy R, Ibraheem IB, Shreadah M, Mohammed R, Ismael A (2015) Antimicrobial activity of
three microalgae isolated from Mediterranean Sea coast, Egypt. J Pure Appl Microbiol 9
(4):2751–2758
53. Pratt R, Daniels TC, Eiler JJ, Gunnison JB, Kumler WD, Oneto JF, Strait LA, Spoehr HA,
Hardin GJ, Milner HW, Smith JH (1944) Chlorellin, an antibacterial substance from Chlorella.
Science (Washington):351–352
54. Ohta S, Shiomi Y, Kawashima A, Aozasa O, Nakao T, Nagate T, Kitamura K, Miyata H (1995)
Antibiotic effect of linolenic acid from Chlorococcum strain HS-101 and Dunaliella primolecta
on methicillin-resistant Staphylococcus aureus. J Appl Phycol 7(2):121–127
55. Pane G, Cacciola G, Giacco E, Mariottini G, Coppo E (2015) Assessment of the antimicrobial
activity of algae extracts on bacteria responsible of external otitis. Mar Drugs 13
(10):6440–6452
56. Ali HI, Doumandji A (2017) Comparative phytochemical analysis and in vitro antimicrobial
activities of the cyanobacterium Spirulina platensis and the green alga Chlorella pyrenoidosa:
potential application of bioactive components as an alternative to infectious diseases. Bulletin
de l’Institut Scientifique, Rabat, Section Sciences de la Vie 39:41–49
57. Navarro F, Forján E, Vázquez M, Toimil A, Montero Z, Ruiz-Domínguez MD, Garbayo I,
Castaño MÁ, Vílchez C, Vega JM (2017) Antimicrobial activity of the acidophilic eukaryotic
microalga Coccomyxa onubensis. Phycol Res 65(1):38–43
58. Lauritano C, Andersen JH, Hansen E, Albrigtsen M, Escalera L, Esposito F, Helland K,
Hanssen KØ, Romano G, Ianora A (2016) Bioactivity screening of microalgae for antioxidant,
anti-inflammatory, anticancer, anti-diabetes, and antibacterial activities. Front Mar Sci 3:68
59. Viso AC, Pesando D, Baby C (1987) Antibacterial and antifungal properties of some marine
diatoms in culture. Bot Mar 30(1):41–46
60. Ghasemi Y, Moradian A, Mohagheghzadeh A, Shokravi S, Morowvat MH (2007) Antifungal
and antibacterial activity of the microalgae collected from paddy fields of Iran: characterization
of antimicrobial activity of Chroococcus dispersus. J Biol Sci 7:904–910
61. Bhagavathy S, Sumathi P, Bell IJ (2011) Green algae Chlorococcum humicola-a new source of
bioactive compounds with antimicrobial activity. Asian Pac J Trop Biomed 1(1):S1–S7
174
S. Sinha et al.
microalgae derived pharmaceutical and biological reagent. Biochem Eng J 109:282–296
45. Talero E, García-Mauriño S, Ávila-Román J, Rodríguez-Luna A, Alcaide A, Motilva V (2015)
Bioactive compounds isolated from microalgae in chronic inflammation and cancer. Mar Drugs
13(10):6152–6209
46. Bleakley S, Hayes M (2017) Algal proteins: extraction, application, and challenges concerning
production. Foods 6(5):33
47. Manzo E, Ciavatta ML, Bakkas S, Villani G, Varcamonti M, Zanfardino A, Gavagnin M (2009)
Diterpene content of the alga Dictyota ciliolata from a Moroccan lagoon. Phytochem Lett 2
(4):211–215
48. Pereira H, Leão-Ferreira LR, Moussatché N, Teixeira VL, Cavalcanti DN, Costa LJ, Diaz R,
Frugulhetti IC (2004) Antiviral activity of diterpenes isolated from the Brazilian marine alga
Dictyota menstrualis against human immunodeficiency virus type 1 (HIV-1). Antiviral Res 64
(1):69–76
49. Lee JB, Hayashi K, Hirata M, Kuroda E, Suzuki E, Kubo Y, Hayashi T (2006) Antiviral sulfated
polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay.
Biol Pharm Bull 29(10):2135–2139
50. Gastineau R, Turcotte F, Pouvreau JB, Morançais M, Fleurence J, Windarto E, Prasetiya F,
Arsad S, Jaouen P, Babin M, Coiffard L (2014) Marennine, promising blue pigments from a
widespread Haslea diatom species complex. Mar Drugs 12(6):3161–3189
51. Yim JH, Kim SJ, Ahn SH, Lee CK, Rhie KT, Lee HK (2004) Antiviral effects of sulfated
exopolysaccharide from the marine microalga Gyrodinium impudicum strain KG03. Marine
Biotechnol 6(1):17–25
52. Elkomy R, Ibraheem IB, Shreadah M, Mohammed R, Ismael A (2015) Antimicrobial activity of
three microalgae isolated from Mediterranean Sea coast, Egypt. J Pure Appl Microbiol 9
(4):2751–2758
53. Pratt R, Daniels TC, Eiler JJ, Gunnison JB, Kumler WD, Oneto JF, Strait LA, Spoehr HA,
Hardin GJ, Milner HW, Smith JH (1944) Chlorellin, an antibacterial substance from Chlorella.
Science (Washington):351–352
54. Ohta S, Shiomi Y, Kawashima A, Aozasa O, Nakao T, Nagate T, Kitamura K, Miyata H (1995)
Antibiotic effect of linolenic acid from Chlorococcum strain HS-101 and Dunaliella primolecta
on methicillin-resistant Staphylococcus aureus. J Appl Phycol 7(2):121–127
55. Pane G, Cacciola G, Giacco E, Mariottini G, Coppo E (2015) Assessment of the antimicrobial
activity of algae extracts on bacteria responsible of external otitis. Mar Drugs 13
(10):6440–6452
56. Ali HI, Doumandji A (2017) Comparative phytochemical analysis and in vitro antimicrobial
activities of the cyanobacterium Spirulina platensis and the green alga Chlorella pyrenoidosa:
potential application of bioactive components as an alternative to infectious diseases. Bulletin
de l’Institut Scientifique, Rabat, Section Sciences de la Vie 39:41–49
57. Navarro F, Forján E, Vázquez M, Toimil A, Montero Z, Ruiz-Domínguez MD, Garbayo I,
Castaño MÁ, Vílchez C, Vega JM (2017) Antimicrobial activity of the acidophilic eukaryotic
microalga Coccomyxa onubensis. Phycol Res 65(1):38–43
58. Lauritano C, Andersen JH, Hansen E, Albrigtsen M, Escalera L, Esposito F, Helland K,
Hanssen KØ, Romano G, Ianora A (2016) Bioactivity screening of microalgae for antioxidant,
anti-inflammatory, anticancer, anti-diabetes, and antibacterial activities. Front Mar Sci 3:68
59. Viso AC, Pesando D, Baby C (1987) Antibacterial and antifungal properties of some marine
diatoms in culture. Bot Mar 30(1):41–46
60. Ghasemi Y, Moradian A, Mohagheghzadeh A, Shokravi S, Morowvat MH (2007) Antifungal
and antibacterial activity of the microalgae collected from paddy fields of Iran: characterization
of antimicrobial activity of Chroococcus dispersus. J Biol Sci 7:904–910
61. Bhagavathy S, Sumathi P, Bell IJ (2011) Green algae Chlorococcum humicola-a new source of
bioactive compounds with antimicrobial activity. Asian Pac J Trop Biomed 1(1):S1–S7
174
S. Sinha et al.