three racemic diorcinol monoethers, versiorcinols A–C (581–583) [179], while
H. koningii gave a tyrosol derivative, hypocrol A (584). Hypocrol A (584) showed
weak antioxidant activity in the DPPH radical-scavenging assay with an IC 50 value
of 48.5 μg/cm
3 [180]. The fungus Penicillium polonicum AP2T1 was obtained from
gills of the shark Isurus oxyrinchus from the Wenzhou sea area of Zhejiang Province. An acetylenic aromatic ether, (À)-WA (585), was obtained from fermentation
O
OH
OH
O
OH
O
O
HO
O
O
OH
OH
OH
O
O
OH
OH
HO
574 (rubrolide R)
575 (rubrolide S)
579 (butyrolactone IX)
580 (aspulvinone O)
HO
O
HO
O
OH
O
576 (aspernolide E)
577 (isobutyrolactone V)
578 (isobutyrolactone II)
O
O
OH
O
O
HO
COOMe
O
OH
O
O
HO
OH
O
O
OH
HO
HO
O
O
HO
O
O
OH
O
O
OH
OH
HO
581 (versiorcinol A)
582 (versiorcinol B)
583 (versiorcinol C)
584 (hypocrol A)
O
O
O
OH
OH
O
O
OH
O
O
O
O
HO
O
O
OR 2
O
OR 1
O
O
OH
O
OH
O
O
O
HO
OH
585 ((–)-WA)
586 (cordyol D)
587 (cordyol E)
591 (tetraorcinol A)
OH
O
O
OH
OH
592
590 (phomaether C)
588 R
1 = β-D-glucopyranosyl, R
2 = H
(phomaether A)
589 R
2 = α-D-glucopyranosyl, R
1 = H
(phomaether B)
Fig. 34 Structures of shikimate-derived compounds
Secondary Metabolites from Marine-Derived Fungi from China
135