one-cycle infection assay with IC 50 values of 4.9, 5.6, and 5.6 μM, respectively
[172]. The fungal strain Gibberella zeae cf-18 was obtained from the marine green
alga Codium fragile collected off the coast of Yantai. Cultivation of G. zeae in liquid
PDB medium gave a pyrrolidinone derivative, 3-hydroxy-5-(hydroxymethyl)-4-(40 -hydroxyphenoxy)pyrrolidin-2-one (557) [173]. Two triazoles, chrysotriazoles A
and B (558 and 559), were isolated from the liquid MH 2 medium fermentation of
O
HN
O S
O
539 (aspochalasin V)
O
HN
O S
O
540 (aspochalasin W)
OH
HN
541 (aspochalazine A)
H
N
OH
OH
O
O OH
OH
O
OH
O
NH
OH
O
O
O
545 8S,9S (pseurotin A 1 )
546 8R,9S (pseurotin A 2 )
547 8R,9R (pseurotin A 3 )
8
9
OH
O
OH
O
NH
OH
O
O
O
548 (pseurotin G)
OH
OH
HO
O
N
R
542 R = OH (arthpyrone A)
543 R = H (arthpyrone B)
O
O
OH
N
OH
544 (arthpyrone C)
O
O
O
HO
O
R
OH
HN
O
550 R = OH (chartarutine B)
551 R = OSO 3 H (chartarutine C)
OSO 3 H
OH
HN
HN
552 (chartarutine D)
OH
OH
OH
OH
HN
O
549 (chartarutine A)
OH
O
HN
O
R
553 3'R,R (chartarutine E)
554 3'S,R (chartarutine F)
OH
OH
OH
HN
O
O
R
3'
555 R =
(chartarutine G)
556 R =
(chartarutine H)
OH
OH
HN
OH
O
OH
557
O
OH
N
N
N
O
RO
OH
558 R = Me (chrysotriazole A)
559 R = H (chrysotriazole B)
Fig. 32 Structures of other alkaloids (part 1)
132
Z. Liu et al.