yielded the fungal strain Aspergillus elegans ZJ-2008010. Fermentation of this
fungus in liquid potato glucose medium resulted in the isolation of two cytochalasins, cytochalasin Z24 (530) and aspochalasin A1 (531), in addition to a phenylalanine derivative, 4
0 -O-methyl-asperphenamate (532). 4
0 -O-Methyl-asperphenamate
(532) exhibited selective antibacterial activity against Staphylococcus epidermidis
with an IC 50 value of 10 μM [165]. Three cyclopenin derivatives,
7-methoxycyclopeptin (533), 7-methoxydehydrocyclopeptin (534), and
7-methoxycyclopenin (535), were obtained following cultivation of Aspergillus
versicolor XZ-4, a crab-derived fungus from Xenograpsus testudinatus collected
from
Kueishantao,
Taiwan, in
liquid
potato dextrose
medium.
7-Methoxycyclopeptin (533) and 7-methoxycyclopenin (535) exhibited antibacterial
activity against Escherichia coli with MIC values of 32 μg/cm
3 for both [157].
Following fermentation of Penicillium oxalicum EN-290, an endophytic fungus
derived from the marine alga Codium fragile collected from the Qingdao coastline,
in liquid potato dextrose medium, the phenolic enamide, methyl (Z )-3(3,4-dihydroxyphenyl)-2-formamidoacrylate (536), was obtained. Compound 536
showed antimicrobial activities against Staphylococcus aureus and Vibrio
O
HN
O
O
O
526 R = H (arthriniumnin A)
528 R = OH (arthriniumnin C)
R
O
HN
O
527 (arthriniumnin B)
O
O
O
O
HN
O
O
529 (arthriniumnin D)
OH
OH
N
H
O
O
O
O
N
H
O
532 (4’-methoxy-asperphenamate)
O
HN
O
O
530 (cytochalasin Z24)
O
OH
O
HN
O
O
531 (aspochalasin A1)
OH
O
537
N
H
O
O
538 (ochratoxin A n-butyl ester)
536
N
H
N
O
O
O
533 (7-methoxycyclopeptin)
N
H
N
O
O
O
534 (7-methoxydehydrocyclopeptin)
N
H
N
O
O
O
535 (7-methoxycyclopenin)
O
HO
HO
HN
O
O
O
HN
O
O
O
OH
OH
O
O
O
O
O
Cl
OH
Fig. 31 Structures of phenylalanine derivatives
130
Z. Liu et al.