trichodermaerin (373) [114]. Fermentation on solid rice medium of Trichoderma
citrinoviride cf-27, isolated from the marine brown alga Dictyopteris prolifera
collected from Zhoushan, yielded a nor-diterpene, citrinovirin (374). Citrinovirin
(374) inhibited the growth of Staphylococcus aureus with an MIC value of 38.5 μM
[115]. The fungal strain Aspergillus wentii na-3 was isolated from the marine brown
alga Sargassum fusiforme collected from Nanao Island. Cultivation of this fungus in
liquid medium containing suberoylanilide hydroxamic acid yielded three norditerpenes, aspewentins AÀC (375–377). These compounds were tested for their
growth inhibition against marine zooplankton (Artemia salina) and against three
marine phytoplankton species (Chattonella marina, Heterosigma akashiwo, and
O
359 (trichocitrin)
O
O
O
O
O
O
O
R
360 R = OH (atranone L)
362 R = H (atranone N)
O
O
O
O
O
O
O
361 (atranone M)
O
O
O
O
O
AcO
O
O
363 (atranone O)
O
O
O
O
O
O
364 (atranone P)
365 (22-epi-methylatranone B)
O
O
O
O
O
O
O
366
O
HO
HO
O
HO
367 (conidiogenone H)
HO
O
OH
368 (conidiogenone I)
HO
O
O
OH
OH
O
369
O
OH
OH
O
370
O
O
OH
371
HO
372
HO
OH
O
O
O
373 (trichodermaerin)
OH
OH
O
O
374 (citrinovirin)
OH
OH
O
O
OH
375 (aspewentin A)
376 (aspewentin B)
377 (aspewentin C)
Fig. 20 Structures of diterpenes
114
Z. Liu et al.