respectively, whereas chondrosterin KÀM (345–347) showed moderate cytotoxic
potency against a panel of cancer cell lines (CNE1, CNE2, HONE1, SUNE1, A549,
GLC82, and HL7702) with IC 50 values ranging from 12 to 59 μM [102–106].
The fungus Stachybotrys chartarum WGC-25C-6 was isolated from the sponge
Niphates recondita, collected from the inner coral reef in Beibuwan Bay.
O
OH
O
OH
328 (pseuboydone A) 329 (pseuboydone B)
O
HO
O
HO
O
HO
OH
O
OAc
330 (scedogiine A) 331 (scedogiine B)
332 (scedogiine C)
333 (scedogiine D)
O
OH
HO
O
334 (scedogiine E) 335 (scedogiine F)
O
O
O
O
O
O
O
O
OH
OH
OH
336 (chondrosterin A) 337 (chondrosterin B)
338 (chondrosterin C) 339 (chondrosterin D)
OH
O
340 (chondrosterin E)
O
O
O
O
341 (chondrosterin F)
HO
OH
HO
342 (hirsutanol E)
OH
COOH
COOH
O
343 (chondrosterin I) 344 (chondrosterin J)
OH
O
HO
HO
HO
O
HO
HO
O
345 (chondrosterin K) 346 (chondrosterin L) 347 (chondrosterin M)
O
O
O
OH
OH
HO
HO
O
HO
O
OH
O
O
OH
OH
O
O
O
O
O
O
O
O
348 (chartarene A)
349 (chartarene B)
350 (chartarene C)
351 (chartarene D)
O
OH
OH
OH
OH
OH
OH
HO
HO
OH
357 (disydonol B)
358 (disydonol C)
R 1
HO
O
OH
HO
352 R
1 = CH 2 OH, R
2 = H (aspergiterpenoid A)
353 R
1 = CH 2 OH, R
2 = OH ((–)-sydonol)
354 R
1 = COOH, R
2 = OH ((–)-sydonic acid)
355 (aspergiterpenoid E)
OH
HO
O
OH
HO
356 (disydonol A)
R 2
Fig. 19 Structures of sesquiterpenes (part 2)
112
Z. Liu et al.