concentrations with EC 50 values of 1.7 and 0.6 μg/cm
3 , respectively [94]. Liquid
potato glucose medium fermentation of Talaromyces sp., a gorgonian-derived fungus from Subergorgia suberosa collected from the South China Sea, yielded three
diphenyl ether derivatives, purpactins D–F (309–311) (Fig. 17) [95].
O
OH
OH
O
O
HO
O
298
O
O
OH
HO
O
HO
O
O
OH
OH
294 (varioxiranol F)
O
O
OH
HO
O
HO
O
O
OH
OH
295 (varioxiranol G)
O
O
OH
O
OH
296 R
1 = OH, R
2 = H (varioxiranol I)
297 R
1 = H, R
2 = OH (varioxiranol J)
R 1 R 2
OH
CHO OH
OH
299 (heterocornol F)
OH
O
OH
300 (heterocornol G)
OH
O
OH
301 (heterocornol H)
Cl
Cl
HO
HO
O
OH
OH
Cl
Cl
O
OH
OH
OH
307 (pestalachloride E)
308 (pestalachloride F)
Cl
Cl
O
306 (pestalachloride D)
O
OH
OH
O
O
309 (purpactin D)
O
O
310 (purpactin E)
O
O
OAc
OAc
O
311 (purpactin F)
O
O
OAc
O
OH
OH
O
OH
R
OH
O
OH
OH
303 (heterocornol J)
OH
O
O
OH
305 (heterocornol L)
O
O
302 R = β-OH (heterocomol I)
304 R = α-OH (heterocomol K)
O
O
O
O
O
O
Fig. 17 Structures of other meroterpenes and prenylated polyketides (part 2)
Secondary Metabolites from Marine-Derived Fungi from China
109