Histone methyltransferases (HMTs), 123–144,
221, 247, 265, 346, 378, 405, 455, 465,
527
Histones, 197, 287
HIV, 19, 66, 130, 140, 168, 181, 202, 298, 341
HL-60, 38
Homology modeling, 455
Honokiol, 79
HOTAIR, 405, 406, 409–413
HPLC, 496
HR73, 65
HT-29, 68
Human anti-transferrin receptor (TfR), 415
Human silent information regulator type
1 (SIRT1), 55
Huntington’s disease (HD), 20, 57, 129
Hydroxamic acid, 7, 29
5-Hydroxymethylcytosine (5hmC), 257, 487
5-Hydroxyuracil (5hmU), 267
Hyperacetylation, 31, 44, 99, 295
Hyperforin, 76
Hypoacetylation, 99, 105, 111
I
I-CBP112, 300
ICL-SIRT078, 73
Imidazothiazoles, 79
Inauhzin, 67
Indoles, 64
Inhibition, 55
Inhibitors, 197, 255
discovery, 287
IOX1, 276
Ischemin, 300
Isogarcinol, 109
J
JARID1A, 345
JGB-1741, 64
JmjC histone demethylases, 221, 472
JMJD6, 162, 340
(+)-JQ1, 302
K
KDMs, 163, 221, 226, 341, 351, 440, 466
KDM5A, 345
KDOAM-25, 242
Krüppel-like factor 2 (KLF2), 412
L
L3MBTL1, 364
Laccaic acid, 265
Largazole, 12, 13
lincRNA-p21, 412
LLY-507, 142
Long chain alkylidene malonates (LoCAMs),
108
Long noncoding RNA (lncRNAs), 401
LSD1 (KDM1A), 199, 469
LSD2 (KDM1B), 199
LTK-14, 109
LuCaP-77, 113
Lung cancer/carcinoma, 63, 101, 129, 181, 200,
261, 299, 341, 409, 429, 469
Luteolin, 78
Lyngbya majuscula, 76
Lys-CoA, 103
Lysine, 197
Lysine demethylases (KDMs), 163, 221, 226,
341, 351, 440, 466
Lysine methylation, 197, 222, 364, 374, 443
Lysine methyltransferases (KMTs), 123, 166,
176, 182, 199, 340, 350, 469
Lysine-specific histone demethylases 1/2
(LSD1/2), 197
M
Malaria, 20
MALAT1, 409, 415
Malignant brain tumor (MBT) domain, 339,
363
Manganese superoxide dismutase (Mn-SOD),
79
Marbostat-100, 10
Mass spectrometry, 487
Matrix metalloproteinases, 7
MC1946, 144
MC2141, 65
MCF-7, 38, 60
MCP-1, 140
Metalloenzymes, 4, 472
Methylation, 159, 197, 523
5-Methylcytosine (5mC), 257
3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-Nhydroxy-2-propenamide (APHA), 34
Methyl-readers, 339
Methylthioadenosine (MTA), 164
MGCD290, 20
MI-1, 140
564
Index
221, 247, 265, 346, 378, 405, 455, 465,
527
Histones, 197, 287
HIV, 19, 66, 130, 140, 168, 181, 202, 298, 341
HL-60, 38
Homology modeling, 455
Honokiol, 79
HOTAIR, 405, 406, 409–413
HPLC, 496
HR73, 65
HT-29, 68
Human anti-transferrin receptor (TfR), 415
Human silent information regulator type
1 (SIRT1), 55
Huntington’s disease (HD), 20, 57, 129
Hydroxamic acid, 7, 29
5-Hydroxymethylcytosine (5hmC), 257, 487
5-Hydroxyuracil (5hmU), 267
Hyperacetylation, 31, 44, 99, 295
Hyperforin, 76
Hypoacetylation, 99, 105, 111
I
I-CBP112, 300
ICL-SIRT078, 73
Imidazothiazoles, 79
Inauhzin, 67
Indoles, 64
Inhibition, 55
Inhibitors, 197, 255
discovery, 287
IOX1, 276
Ischemin, 300
Isogarcinol, 109
J
JARID1A, 345
JGB-1741, 64
JmjC histone demethylases, 221, 472
JMJD6, 162, 340
(+)-JQ1, 302
K
KDMs, 163, 221, 226, 341, 351, 440, 466
KDM5A, 345
KDOAM-25, 242
Krüppel-like factor 2 (KLF2), 412
L
L3MBTL1, 364
Laccaic acid, 265
Largazole, 12, 13
lincRNA-p21, 412
LLY-507, 142
Long chain alkylidene malonates (LoCAMs),
108
Long noncoding RNA (lncRNAs), 401
LSD1 (KDM1A), 199, 469
LSD2 (KDM1B), 199
LTK-14, 109
LuCaP-77, 113
Lung cancer/carcinoma, 63, 101, 129, 181, 200,
261, 299, 341, 409, 429, 469
Luteolin, 78
Lyngbya majuscula, 76
Lys-CoA, 103
Lysine, 197
Lysine demethylases (KDMs), 163, 221, 226,
341, 351, 440, 466
Lysine methylation, 197, 222, 364, 374, 443
Lysine methyltransferases (KMTs), 123, 166,
176, 182, 199, 340, 350, 469
Lysine-specific histone demethylases 1/2
(LSD1/2), 197
M
Malaria, 20
MALAT1, 409, 415
Malignant brain tumor (MBT) domain, 339,
363
Manganese superoxide dismutase (Mn-SOD),
79
Marbostat-100, 10
Mass spectrometry, 487
Matrix metalloproteinases, 7
MC1946, 144
MC2141, 65
MCF-7, 38, 60
MCP-1, 140
Metalloenzymes, 4, 472
Methylation, 159, 197, 523
5-Methylcytosine (5mC), 257
3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-Nhydroxy-2-propenamide (APHA), 34
Methyl-readers, 339
Methylthioadenosine (MTA), 164
MGCD290, 20
MI-1, 140
564
Index