Diclone, 265
Dihydropyridines, 77
Dihydroquinazolinone, 300
Direct detection, 487
Disulfiram, 346
DNA damage response (DDR), 99, 135, 349,
412
DNA hydroxymethylation, 255
DNA methylation, 255, 259
DNA methyltransferases (DNMTs), 164, 255–
261, 344, 358, 429, 440, 487
DNA repair, 99, 106, 140, 143, 163, 166, 258,
357
Disruptor of telomeric silencing 1-like
(DOT1L), 123, 135
Drug design/development, 55
Drug discovery, structure-and ligand-based, 93
DU 145, 60
DZNep, 130
E
E11, 205
EBI-2511, 133
EED226, 134
EHMTs, 126
EI1, 131
EML425, 109
Enzyme-linked immunosorbent assay (ELISA),
494
Epidrugs, 417, 420, 431, 432
Epigenetic inhibitors, 263, 455–475
Epigenetic modulators, 123, 525
Epigenetic readers, 326, 339, 417
Epigenetic therapy, 289, 401, 417
Epstein-Barr virus (EBV), 19, 20, 179
EPZ-5676, 136
EPZ004777, 136
EPZ005687, 131
EPZ031686, 143
Esophageal squamous cell carcinoma (ESCC),
44
Euchromatin histone methyltransferases
(EHMTs), 126
Ex-527, 66
EZH1/2, 123, 130
F
Fat mass and obesity-associated (FTO)
proteins, 271
Fbox Only Protein 11 (FBXO11), 185
Filgastat, 248
FK228, 12
FL-411, 303
Flavanone 69, 265
Fluconazole, 20
Fluorescence polarization, 321
5-Fluorocytidine, 263
5-Formylcytosine (5fC), 257, 487
Fucoidan, 79
5-(3-(Furan-2-carboxamido)benzamido)-2hydroxybenzoic acid, 74
G
G9a, 123
G9a/GLP inhibitors
non-SAM-competitive, 127
SAM-competitive, 129
GA001, 468
Garcinia cochinchinensis, 76
GATA4, 130
Gcn5-related N-acetyltransferase (GNAT), 95
Gemcitabine, 75, 411
Genitopatellar syndrome, 96, 102
Ginsenosides, 78
Givinostat, 8
GLIB-Seq, 504
Glioblastoma, 65, 101, 111, 135, 410–416
Globin disorders, 202
G-protein antagonists, 72
GSK-J1, 243
GSK-J2, 244
GSK126, 131
GSK343, 131
GSK-690, 205
GSK2807, 143
Guttiferone, 76
GW5054, 68, 69
H
H3K4, 441
HC-toxin, 39
Hemoglobin F (HbF), 126
Hepatitis B, 19, 20, 202
Hepatocellular carcinoma (HCC), 144, 167,
225, 410
Herpes simplex virus (HSV), 201, 203
Histone acetyltransferases (HATs), 93
Histone deacetylases (HDACs), 1–21, 29–47,
57, 289, 404, 455, 459
Histone demethylases (KDMs), 164, 197–213,
222–249, 441, 455, 469, 473
Histone H3 lysine 9 (H3K9), 63
Index
563
Dihydropyridines, 77
Dihydroquinazolinone, 300
Direct detection, 487
Disulfiram, 346
DNA damage response (DDR), 99, 135, 349,
412
DNA hydroxymethylation, 255
DNA methylation, 255, 259
DNA methyltransferases (DNMTs), 164, 255–
261, 344, 358, 429, 440, 487
DNA repair, 99, 106, 140, 143, 163, 166, 258,
357
Disruptor of telomeric silencing 1-like
(DOT1L), 123, 135
Drug design/development, 55
Drug discovery, structure-and ligand-based, 93
DU 145, 60
DZNep, 130
E
E11, 205
EBI-2511, 133
EED226, 134
EHMTs, 126
EI1, 131
EML425, 109
Enzyme-linked immunosorbent assay (ELISA),
494
Epidrugs, 417, 420, 431, 432
Epigenetic inhibitors, 263, 455–475
Epigenetic modulators, 123, 525
Epigenetic readers, 326, 339, 417
Epigenetic therapy, 289, 401, 417
Epstein-Barr virus (EBV), 19, 20, 179
EPZ-5676, 136
EPZ004777, 136
EPZ005687, 131
EPZ031686, 143
Esophageal squamous cell carcinoma (ESCC),
44
Euchromatin histone methyltransferases
(EHMTs), 126
Ex-527, 66
EZH1/2, 123, 130
F
Fat mass and obesity-associated (FTO)
proteins, 271
Fbox Only Protein 11 (FBXO11), 185
Filgastat, 248
FK228, 12
FL-411, 303
Flavanone 69, 265
Fluconazole, 20
Fluorescence polarization, 321
5-Fluorocytidine, 263
5-Formylcytosine (5fC), 257, 487
Fucoidan, 79
5-(3-(Furan-2-carboxamido)benzamido)-2hydroxybenzoic acid, 74
G
G9a, 123
G9a/GLP inhibitors
non-SAM-competitive, 127
SAM-competitive, 129
GA001, 468
Garcinia cochinchinensis, 76
GATA4, 130
Gcn5-related N-acetyltransferase (GNAT), 95
Gemcitabine, 75, 411
Genitopatellar syndrome, 96, 102
Ginsenosides, 78
Givinostat, 8
GLIB-Seq, 504
Glioblastoma, 65, 101, 111, 135, 410–416
Globin disorders, 202
G-protein antagonists, 72
GSK-J1, 243
GSK-J2, 244
GSK126, 131
GSK343, 131
GSK-690, 205
GSK2807, 143
Guttiferone, 76
GW5054, 68, 69
H
H3K4, 441
HC-toxin, 39
Hemoglobin F (HbF), 126
Hepatitis B, 19, 20, 202
Hepatocellular carcinoma (HCC), 144, 167,
225, 410
Herpes simplex virus (HSV), 201, 203
Histone acetyltransferases (HATs), 93
Histone deacetylases (HDACs), 1–21, 29–47,
57, 289, 404, 455, 459
Histone demethylases (KDMs), 164, 197–213,
222–249, 441, 455, 469, 473
Histone H3 lysine 9 (H3K9), 63
Index
563