BAY123807, 303
BAZ-PHD fingers, 348
BCL2, 18, 369, 498
Belinostat, 8, 11, 32
Benzodeazaoxaflavins, 66
BETs, 301–304, 320
BF1, 111
Binding free energy calculations, 455
Biophysical assays, 287
Bisbenzylidenebenzene-1,4-diamines, 72
Bisbenzylidenenaphthalene-1,4-diamines, 72
Bisindolylmaleimides (BIMs), 59
Bispiperazinecarbodithioic acid methyl ester,
75
Bisubstrate inhibitors, 103, 168, 176
Bisulfite sequencing, 505
BIX01294 (diazepin-quinazoline-amines), 127,
247
Bizine, 205
Bladder cancer, 144, 166, 169, 201, 203, 372,
374, 412
Bn-SNF, 143
brahma gene, 290
BRCA1, 101, 357
BRD4, 303–325, 535
BRD4770, 127, 129
BRD9539, 129
Breast carcinoma, 11, 60–71, 75, 98–101, 126,
135, 170, 201, 212, 237, 303, 312, 357,
372, 409–414, 492
Bromodomain, 3, 97, 287, 344, 348, 382, 417,
530, 535
(S)-8-Bromo-6-chloro-2-pentylchroman-4-one,
69
8-Bromo-NAD, 59
Burkitt’s lymphoma, 66
Butein, 78
BxPC-3, 75
C
C107, 111, 112
Cambinol, 65, 66
Carbonic anhydrase, 7
5-Carboxycytosine (5caC), 257, 487
Cardiac hypertrophy, 20, 57, 102, 303, 419
CARM1 (PRMT4), 173
CBP/p300, 299
CBX6, 355
CBX7, 350
Chemical probes, 93
Chidamide, 14
Chlamydocin, 39, 41
4-Chlorophenyl pyrazole carboxamide, 68
Chromanones, 64, 69
Chromatin, 123, 181, 289
domains, 339, 374
modification, 95, 289, 401
remodelling, 31, 95, 141, 146, 257, 277,
344, 431, 489, 526
Chromodomains, 350
Chronic lymphocytic leukaemia (CLL), 272,
411, 412
Chronic myelogenous leukemia, 144
Chronic myelomonocytic leukaemia (CMML),
262
Chronic obstructive pulmonary disease
(COPD), 429
Cisplatin, 18, 410, 413–415
Citarinostat, 9
Citrulline, 162, 289
Colon cancer, 62, 65, 68, 169, 237, 261
Colorectal carcinoma, 65, 101, 178, 180, 213,
225, 378
Computational chemistry, 455
CoREST, 31
CP2, 246
Cpd5, 264
CPI-455, 242
CPI-1205, 132
CPTH2, 111
CPTH6, 111
CREB-binding protein (CBP), 299
CUDC-101, 11
Curcuma longa, 109
Curcumin, 107, 109
Cutaneous squamous cell carcinoma (CSCC),
101
Cyanidin, 78
Cyclic peptides, 29
Cyclin-dependent kinase inhibitor p21 (CIP1/
WAF1), 18
cyl-1/2, 39
Cystic fibrosis, 20, 44, 261
Cytosine-5-methylenesulfonate (CMS), 504
D
DC_C01, 468
Deacetylase inhibitors (HDACi), 135, 429–445
Deacetylation, 55
3-Deazaneplanocin (DZNep), 131
Decitabine, 492
Demethylases, 197
Desethylamiodarone, 346
Diabetes, 20, 57, 78, 140, 166, 171
562
Index
BAZ-PHD fingers, 348
BCL2, 18, 369, 498
Belinostat, 8, 11, 32
Benzodeazaoxaflavins, 66
BETs, 301–304, 320
BF1, 111
Binding free energy calculations, 455
Biophysical assays, 287
Bisbenzylidenebenzene-1,4-diamines, 72
Bisbenzylidenenaphthalene-1,4-diamines, 72
Bisindolylmaleimides (BIMs), 59
Bispiperazinecarbodithioic acid methyl ester,
75
Bisubstrate inhibitors, 103, 168, 176
Bisulfite sequencing, 505
BIX01294 (diazepin-quinazoline-amines), 127,
247
Bizine, 205
Bladder cancer, 144, 166, 169, 201, 203, 372,
374, 412
Bn-SNF, 143
brahma gene, 290
BRCA1, 101, 357
BRD4, 303–325, 535
BRD4770, 127, 129
BRD9539, 129
Breast carcinoma, 11, 60–71, 75, 98–101, 126,
135, 170, 201, 212, 237, 303, 312, 357,
372, 409–414, 492
Bromodomain, 3, 97, 287, 344, 348, 382, 417,
530, 535
(S)-8-Bromo-6-chloro-2-pentylchroman-4-one,
69
8-Bromo-NAD, 59
Burkitt’s lymphoma, 66
Butein, 78
BxPC-3, 75
C
C107, 111, 112
Cambinol, 65, 66
Carbonic anhydrase, 7
5-Carboxycytosine (5caC), 257, 487
Cardiac hypertrophy, 20, 57, 102, 303, 419
CARM1 (PRMT4), 173
CBP/p300, 299
CBX6, 355
CBX7, 350
Chemical probes, 93
Chidamide, 14
Chlamydocin, 39, 41
4-Chlorophenyl pyrazole carboxamide, 68
Chromanones, 64, 69
Chromatin, 123, 181, 289
domains, 339, 374
modification, 95, 289, 401
remodelling, 31, 95, 141, 146, 257, 277,
344, 431, 489, 526
Chromodomains, 350
Chronic lymphocytic leukaemia (CLL), 272,
411, 412
Chronic myelogenous leukemia, 144
Chronic myelomonocytic leukaemia (CMML),
262
Chronic obstructive pulmonary disease
(COPD), 429
Cisplatin, 18, 410, 413–415
Citarinostat, 9
Citrulline, 162, 289
Colon cancer, 62, 65, 68, 169, 237, 261
Colorectal carcinoma, 65, 101, 178, 180, 213,
225, 378
Computational chemistry, 455
CoREST, 31
CP2, 246
Cpd5, 264
CPI-455, 242
CPI-1205, 132
CPTH2, 111
CPTH6, 111
CREB-binding protein (CBP), 299
CUDC-101, 11
Curcuma longa, 109
Curcumin, 107, 109
Cutaneous squamous cell carcinoma (CSCC),
101
Cyanidin, 78
Cyclic peptides, 29
Cyclin-dependent kinase inhibitor p21 (CIP1/
WAF1), 18
cyl-1/2, 39
Cystic fibrosis, 20, 44, 261
Cytosine-5-methylenesulfonate (CMS), 504
D
DC_C01, 468
Deacetylase inhibitors (HDACi), 135, 429–445
Deacetylation, 55
3-Deazaneplanocin (DZNep), 131
Decitabine, 492
Demethylases, 197
Desethylamiodarone, 346
Diabetes, 20, 57, 78, 140, 166, 171
562
Index