35. Lalonde ME, Avvakumov N, Glass KC, Joncas FH, Saksouk N, Holliday M, Paquet E, Yan K,
Tong Q, Klein BJ, Tan S, Yang XJ, Kutateladze TG, Cote J (2013) Exchange of associated
factors directs a switch in HBO1 acetyltransferase histone tail specificity. Genes Dev
27:2009–2024. https://doi.org/10.1101/gad.223396.113
36. Karmodiya K, Anamika K, Muley V, Pradhan SJ, Bhide Y, Galande S (2014) Camello, a novel
family of Histone Acetyltransferases that acetylate histone H4 and is essential for zebrafish
development. Sci Rep 4:6076. https://doi.org/10.1038/srep06076
37. Iyer NG, Ozdag H, Caldas C (2004) p300/CBP and cancer. Oncogene 23:4225–4231
38. Sun XJ, Man N, Tan Y, Nimer SD, Wang L (2015) The role of histone acetyltransferases in
normal and malignant hematopoiesis. Front Oncol 5:108
39. Mullighan CG, Zhang J, Kasper LH, Lerach S, Payne-Turner D, Phillips LA, Heatley SL,
Holmfeldt L, Collins-Underwood JR, Ma J, Buetow KH, Pui CH, Baker SD, Brindle PK,
Downing JR (2011) CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature
471:235–239. https://doi.org/10.1038/nature09727
40. Kishimoto M, Kohno T, Okudela K, Otsuka A, Sasaki H, Tanabe C, Sakiyama T, Hirama C,
Kitabayashi I, Minna JD, Takenoshita S, Yokota J (2005) Mutations and deletions of the CBP
gene in human lung cancer. Clin Cancer Res 11:512–519
41. Gayther SA, Batley SJ, Linger L, Bannister A, Thorpe K, Chin SF, Daigo Y, Russell P,
Wilson A, Sowter HM, Delhanty JD, Ponder BA, Kouzarides T, Caldas C (2000) Mutations
truncating the EP300 acetylase in human cancers. Nat Genet 24:300–303
42. Yokomizo C, Yamaguchi K, Itoh Y, Nishimura T, Umemura A, Minami M, Yasui K,
Mitsuyoshi H, Fujii H, Tochiki N, Nakajima T, Okanoue T, Yoshikawa T (2011) High
expression of p300 in HCC predicts shortened overall survival in association with enhanced
epithelial mesenchymal transition of HCC cells. Cancer Lett 310:140–147
43. Xiao XS, Cai MY, Chen JW, Guan XY, Kung HF, Zeng YX, Xie D (2011) High expression of
p300 in human breast cancer correlates with tumor recurrence and predicts adverse prognosis.
Chin J Cancer Res 23:201–207
44. Chen MK, Cai MY, Luo RZ, Tian X, Liao QM, Zhang XY, Han JD (2015) Overexpression of
p300 correlates with poor prognosis in patients with cutaneous squamous cell carcinoma. Br J
Dermatol 172:111–119
45. Li M, Luo RZ, Chen JW, Cao Y, Lu JB, He JH, Wu QL, Cai MY (2011) High expression of
transcriptional coactivator p300 correlates with aggressive features and poor prognosis of
hepatocellular carcinoma. J Transl Med 9:5
46. Vervoorts J, Lüscher-Firzlaff JM, Rottmann S, Lilischkis R, Walsemann G, Dohmann K,
Austen M, Lüscher B (2003) Stimulation of c-MYC transcriptional activity and acetylation by
recruitment of the cofactor CBP. EMBO Rep 4:484–490
47. Zhong J, Ding L, Bohrer LR, Pan Y, Liu P, Zhang J, Sebo TJ, Karnes RJ, Tindall DJ, van
Deursen J, Huang H (2014) p300 acetyltransferase regulates androgen receptor degradation
and PTEN-deficient prostate tumorigenesis. Cancer Res 74:1870–1880
48. Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM (2000) CBP/p300 interact with and
function as transcriptional coactivators of BRCA1. Proc Natl Acad Sci U S A 97:1020–1025
49. Teufel DP, Freund SM, Bycroft M, Fersht AR (2007) Four domains of p300 each bind tightly
to a sequence spanning both transactivation subdomains of p53. Proc Natl Acad Sci U S A
104:7009–7014
50. Simo-Riudalbas L, Perez-Salvia M, Setien F, Villanueva A, Moutinho C, Martinez-Cardus A,
Moran S, Berdasco M, Gomez A, Vidal E, Soler M, Heyn H, Vaquero A, de la Torre C,
Barcelo-Batllori S, Vidal A, Roz L, Pastorino U, Szakszon K, Borck G, Moura CS, Carneiro F,
Zondervan I, Savola S, Iwakawa R, Kohno T, Yokota J, Esteller M (2015) KAT6B is a tumor
suppressor histone H3 lysine 23 acetyltransferase undergoing genomic loss in small cell lung
cancer. Cancer Res 75:3936–3945. https://doi.org/10.1158/0008-5472.CAN-14-3702
51. Liu N, Zhang R, Zhao X, Su J, Bian X, Ni J, Yue Y, Cai Y, Jin J (2013) A potential diagnostic
marker for ovarian cancer: involvement of the histone acetyltransferase, human males absent
on the first. Oncol Lett 6:393–400. https://doi.org/10.3892/ol.2013.1380
Histone Acetyltransferase Enzymes: From Biological Implications to Most. . .
117
Tong Q, Klein BJ, Tan S, Yang XJ, Kutateladze TG, Cote J (2013) Exchange of associated
factors directs a switch in HBO1 acetyltransferase histone tail specificity. Genes Dev
27:2009–2024. https://doi.org/10.1101/gad.223396.113
36. Karmodiya K, Anamika K, Muley V, Pradhan SJ, Bhide Y, Galande S (2014) Camello, a novel
family of Histone Acetyltransferases that acetylate histone H4 and is essential for zebrafish
development. Sci Rep 4:6076. https://doi.org/10.1038/srep06076
37. Iyer NG, Ozdag H, Caldas C (2004) p300/CBP and cancer. Oncogene 23:4225–4231
38. Sun XJ, Man N, Tan Y, Nimer SD, Wang L (2015) The role of histone acetyltransferases in
normal and malignant hematopoiesis. Front Oncol 5:108
39. Mullighan CG, Zhang J, Kasper LH, Lerach S, Payne-Turner D, Phillips LA, Heatley SL,
Holmfeldt L, Collins-Underwood JR, Ma J, Buetow KH, Pui CH, Baker SD, Brindle PK,
Downing JR (2011) CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature
471:235–239. https://doi.org/10.1038/nature09727
40. Kishimoto M, Kohno T, Okudela K, Otsuka A, Sasaki H, Tanabe C, Sakiyama T, Hirama C,
Kitabayashi I, Minna JD, Takenoshita S, Yokota J (2005) Mutations and deletions of the CBP
gene in human lung cancer. Clin Cancer Res 11:512–519
41. Gayther SA, Batley SJ, Linger L, Bannister A, Thorpe K, Chin SF, Daigo Y, Russell P,
Wilson A, Sowter HM, Delhanty JD, Ponder BA, Kouzarides T, Caldas C (2000) Mutations
truncating the EP300 acetylase in human cancers. Nat Genet 24:300–303
42. Yokomizo C, Yamaguchi K, Itoh Y, Nishimura T, Umemura A, Minami M, Yasui K,
Mitsuyoshi H, Fujii H, Tochiki N, Nakajima T, Okanoue T, Yoshikawa T (2011) High
expression of p300 in HCC predicts shortened overall survival in association with enhanced
epithelial mesenchymal transition of HCC cells. Cancer Lett 310:140–147
43. Xiao XS, Cai MY, Chen JW, Guan XY, Kung HF, Zeng YX, Xie D (2011) High expression of
p300 in human breast cancer correlates with tumor recurrence and predicts adverse prognosis.
Chin J Cancer Res 23:201–207
44. Chen MK, Cai MY, Luo RZ, Tian X, Liao QM, Zhang XY, Han JD (2015) Overexpression of
p300 correlates with poor prognosis in patients with cutaneous squamous cell carcinoma. Br J
Dermatol 172:111–119
45. Li M, Luo RZ, Chen JW, Cao Y, Lu JB, He JH, Wu QL, Cai MY (2011) High expression of
transcriptional coactivator p300 correlates with aggressive features and poor prognosis of
hepatocellular carcinoma. J Transl Med 9:5
46. Vervoorts J, Lüscher-Firzlaff JM, Rottmann S, Lilischkis R, Walsemann G, Dohmann K,
Austen M, Lüscher B (2003) Stimulation of c-MYC transcriptional activity and acetylation by
recruitment of the cofactor CBP. EMBO Rep 4:484–490
47. Zhong J, Ding L, Bohrer LR, Pan Y, Liu P, Zhang J, Sebo TJ, Karnes RJ, Tindall DJ, van
Deursen J, Huang H (2014) p300 acetyltransferase regulates androgen receptor degradation
and PTEN-deficient prostate tumorigenesis. Cancer Res 74:1870–1880
48. Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM (2000) CBP/p300 interact with and
function as transcriptional coactivators of BRCA1. Proc Natl Acad Sci U S A 97:1020–1025
49. Teufel DP, Freund SM, Bycroft M, Fersht AR (2007) Four domains of p300 each bind tightly
to a sequence spanning both transactivation subdomains of p53. Proc Natl Acad Sci U S A
104:7009–7014
50. Simo-Riudalbas L, Perez-Salvia M, Setien F, Villanueva A, Moutinho C, Martinez-Cardus A,
Moran S, Berdasco M, Gomez A, Vidal E, Soler M, Heyn H, Vaquero A, de la Torre C,
Barcelo-Batllori S, Vidal A, Roz L, Pastorino U, Szakszon K, Borck G, Moura CS, Carneiro F,
Zondervan I, Savola S, Iwakawa R, Kohno T, Yokota J, Esteller M (2015) KAT6B is a tumor
suppressor histone H3 lysine 23 acetyltransferase undergoing genomic loss in small cell lung
cancer. Cancer Res 75:3936–3945. https://doi.org/10.1158/0008-5472.CAN-14-3702
51. Liu N, Zhang R, Zhao X, Su J, Bian X, Ni J, Yue Y, Cai Y, Jin J (2013) A potential diagnostic
marker for ovarian cancer: involvement of the histone acetyltransferase, human males absent
on the first. Oncol Lett 6:393–400. https://doi.org/10.3892/ol.2013.1380
Histone Acetyltransferase Enzymes: From Biological Implications to Most. . .
117