17. Boggs AE, Vitolo MI, Whipple RA, Charpentier MS, Goloubeva OG, Ioffe OB, Tuttle KC,
Slovic J, Lu Y, Mills GB, Martin SS (2015) α-Tubulin acetylation elevated in metastatic and
basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration. Cancer Res 75:203–215
18. Sapountzi V, Côté J (2011) MYST-family histone acetyltransferases: beyond chromatin. Cell
Mol Life Sci 68:1147–1156
19. Avvakumov N, Côté J (2007) The MYST family of histone acetyltransferases and their
intimate links to cancer. Oncogene 26:5395–5407
20. Patel JH, Du Y, Ard PG, Phillips C, Carella B, Chen CJ, Rakowski C, Chatterjee C, Lieberman
PM, Lane WS, Blobel GA, McMahon SB (2004) The c-MYC oncoprotein is a substrate of the
acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol 24:10826–10834. https://doi.org/
10.1128/MCB.24.24.10826-10834.2004
21. Tang Y, Luo J, Zhang W, Gu W (2006) Tip60-dependent acetylation of p53 modulates the
decision between cell-cycle arrest and apoptosis. Mol Cell 24:827–839
22. van den Broeck A, Nissou D, Brambilla E, Eymin B, Gazzeri S (2012) Activation of a Tip60/
E2F1/ERCC1 network in human lung adenocarcinoma cells exposed to cisplatin. Carcinogenesis 33:320–325
23. Murr R, Loizou JI, Yang YG, Cuenin C, Li H, Wang ZQ, Herceg Z (2006) Histone acetylation
by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks.
Nat Cell Biol 8:91–99
24. Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB (2006)
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell
24:841–851
25. Su J, Wang F, Cai Y, Jin J (2016) The functional analysis of histone acetyltransferase MOF in
tumorigenesis. Int J Mol Sci 17. https://doi.org/10.3390/ijms17010099
26. Taipale M, Rea S, Richter K, Vilar A, Lichter P, Imhof A, Akhtar A (2005) hMOF histone
acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell
Biol 25:6798–6810. https://doi.org/10.1128/MCB.25.15.6798-6810.2005
27. Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Bottinger L, Martensson CU,
Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N,
Becker T, Akhtar A (2016) MOF acetyl transferase regulates transcription and respiration in
mitochondria. Cell 167:722–738.e23. https://doi.org/10.1016/j.cell.2016.09.052
28. Borrow J, Stanton VP Jr, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI,
Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE,
Housman DE (1996) The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a
putative acetyltransferase to the CREB-binding protein. Nat Genet 14:33–41
29. Chaffanet M, Gressin L, Preudhomme C, Soenen-Cornu V, Birnbaum D, Pébusque MJ (2000)
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). Genes Chromosomes
Cancer 28:138–144
30. Yang XJ, Ullah M (2007) MOZ and MORF, two large MYSTic HATs in normal and cancer
stem cells. Oncogene 26:5408–5419. https://doi.org/10.1038/sj.onc.1210609
31. Perez-Campo FM, Costa G, Lie-a-Ling M, Kouskoff V, Lacaud G (2013) The MYSTerious
MOZ, a histone acetyltransferase with a key role in haematopoiesis. Immunology
139:161–165. https://doi.org/10.1111/imm.12072
32. Perez-Campo FM, Borrow J, Kouskoff V, Lacaud G (2009) The histone acetyl transferase
activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic
precursors. Blood 113:4866–4874. https://doi.org/10.1182/blood-2008-04-152017
33. Crump JG, Swartz ME, Eberhart JK, Kimmel CB (2006) Moz-dependent Hox expression
controls segment-specific fate maps of skeletal precursors in the face. Development
133:2661–2669. https://doi.org/10.1242/dev.02435
34. Iizuka M, Stillman B (1999) Histone acetyltransferase HBO1 interacts with the ORC1 subunit
of the human initiator protein. J Biol Chem 274:23027–23034
116
D. Trisciuoglio and D. Rotili
Slovic J, Lu Y, Mills GB, Martin SS (2015) α-Tubulin acetylation elevated in metastatic and
basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration. Cancer Res 75:203–215
18. Sapountzi V, Côté J (2011) MYST-family histone acetyltransferases: beyond chromatin. Cell
Mol Life Sci 68:1147–1156
19. Avvakumov N, Côté J (2007) The MYST family of histone acetyltransferases and their
intimate links to cancer. Oncogene 26:5395–5407
20. Patel JH, Du Y, Ard PG, Phillips C, Carella B, Chen CJ, Rakowski C, Chatterjee C, Lieberman
PM, Lane WS, Blobel GA, McMahon SB (2004) The c-MYC oncoprotein is a substrate of the
acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol 24:10826–10834. https://doi.org/
10.1128/MCB.24.24.10826-10834.2004
21. Tang Y, Luo J, Zhang W, Gu W (2006) Tip60-dependent acetylation of p53 modulates the
decision between cell-cycle arrest and apoptosis. Mol Cell 24:827–839
22. van den Broeck A, Nissou D, Brambilla E, Eymin B, Gazzeri S (2012) Activation of a Tip60/
E2F1/ERCC1 network in human lung adenocarcinoma cells exposed to cisplatin. Carcinogenesis 33:320–325
23. Murr R, Loizou JI, Yang YG, Cuenin C, Li H, Wang ZQ, Herceg Z (2006) Histone acetylation
by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks.
Nat Cell Biol 8:91–99
24. Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB (2006)
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell
24:841–851
25. Su J, Wang F, Cai Y, Jin J (2016) The functional analysis of histone acetyltransferase MOF in
tumorigenesis. Int J Mol Sci 17. https://doi.org/10.3390/ijms17010099
26. Taipale M, Rea S, Richter K, Vilar A, Lichter P, Imhof A, Akhtar A (2005) hMOF histone
acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell
Biol 25:6798–6810. https://doi.org/10.1128/MCB.25.15.6798-6810.2005
27. Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Bottinger L, Martensson CU,
Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N,
Becker T, Akhtar A (2016) MOF acetyl transferase regulates transcription and respiration in
mitochondria. Cell 167:722–738.e23. https://doi.org/10.1016/j.cell.2016.09.052
28. Borrow J, Stanton VP Jr, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI,
Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE,
Housman DE (1996) The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a
putative acetyltransferase to the CREB-binding protein. Nat Genet 14:33–41
29. Chaffanet M, Gressin L, Preudhomme C, Soenen-Cornu V, Birnbaum D, Pébusque MJ (2000)
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). Genes Chromosomes
Cancer 28:138–144
30. Yang XJ, Ullah M (2007) MOZ and MORF, two large MYSTic HATs in normal and cancer
stem cells. Oncogene 26:5408–5419. https://doi.org/10.1038/sj.onc.1210609
31. Perez-Campo FM, Costa G, Lie-a-Ling M, Kouskoff V, Lacaud G (2013) The MYSTerious
MOZ, a histone acetyltransferase with a key role in haematopoiesis. Immunology
139:161–165. https://doi.org/10.1111/imm.12072
32. Perez-Campo FM, Borrow J, Kouskoff V, Lacaud G (2009) The histone acetyl transferase
activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic
precursors. Blood 113:4866–4874. https://doi.org/10.1182/blood-2008-04-152017
33. Crump JG, Swartz ME, Eberhart JK, Kimmel CB (2006) Moz-dependent Hox expression
controls segment-specific fate maps of skeletal precursors in the face. Development
133:2661–2669. https://doi.org/10.1242/dev.02435
34. Iizuka M, Stillman B (1999) Histone acetyltransferase HBO1 interacts with the ORC1 subunit
of the human initiator protein. J Biol Chem 274:23027–23034
116
D. Trisciuoglio and D. Rotili