Compliance with Ethical Standards
Conflict of Interest: The authors declare no conflict of interest.
Ethical Approval: This article does not contain any studies with human participants or animals
performed by any of the authors.
References
1. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
(2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science 325:834–840. https://doi.org/10.1126/science.1175371
2. Roth SY, Denu JM, Allis CD (2001) Histone acetyltransferases. Annu Rev Biochem
70:81–120
3. Lee KK, Workman JL (2007) Histone acetyltransferase complexes: one size doesn’t fit all. Nat
Rev Mol Cell Biol 8:284–295
4. Kalkhoven E (2004) CBP and p300: HATs for different occasions. Biochem Pharmacol
68:1145–1155
5. Wang R, Cherukuri P, Luo J (2005) Activation of Stat3 sequence-specific DNA binding and
transcription by p300/CREB-binding protein-mediated acetylation. J Biol Chem
280:11528–11534. https://doi.org/10.1074/jbc.M413930200
6. Sano Y, Ishii S (2001) Increased affinity of c-Myb for CREB-binding protein (CBP) after
CBP-induced acetylation. J Biol Chem 276:3674–3682. https://doi.org/10.1074/jbc.
M006896200
7. Chan HM, La Thangue NB (2001) p300/CBP proteins: HATs for transcriptional bridges and
scaffolds. J Cell Sci 114:2363–2373
8. di Martile M, del Bufalo D, Trisciuoglio D (2016) The multifaceted role of lysine acetylation
in cancer: prognostic biomarker and therapeutic target. Oncotarget 7:55789–55810. https://
doi.org/10.18632/oncotarget.10048
9. Esteller M (2008) Epigenetics in cancer. N Engl J Med 358:1148–1159. https://doi.org/10.
1056/NEJMra072067
10. Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, Fukamizu A (2005) Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl
Acad Sci U S A 102:11278–11283. https://doi.org/10.1073/pnas.0502738102
11. Dyda F, Klein DC, Hickman AB (2000) GCN5-related N-acetyltransferases: a structural
overview. Annu Rev Biophys Biomol Struct 29:81–103
12. Love IM, Sekaric P, Shi D, Grossman SR, Androphy EJ (2012) The histone acetyltransferase
PCAF regulates p21 transcription through stress-induced acetylation of histone H3. Cell Cycle
11:2458–2466
13. Kormendi V, Szyk A, Piszczek G, Roll-Mecak A (2012) Crystal structures of tubulin
acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N
terminus. J Biol Chem 287:41569–41575
14. Taschner M, Vetter M, Lorentzen E (2012) Atomic resolution structure of human α-tubulin
acetyltransferase bound to acetyl-CoA. Proc Natl Acad Sci U S A 109:19649–19654
15. Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R (2012) Structure of the
α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation. Proc
Natl Acad Sci U S A 109:19655–19660
16. Castro-Castro A, Janke C, Montagnac G, Paul-Gilloteaux P, Chavrier P (2012) ATAT1/MEC17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin
and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion. Eur J Cell
Biol 91:950–960
Histone Acetyltransferase Enzymes: From Biological Implications to Most. . .
115
Conflict of Interest: The authors declare no conflict of interest.
Ethical Approval: This article does not contain any studies with human participants or animals
performed by any of the authors.
References
1. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
(2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science 325:834–840. https://doi.org/10.1126/science.1175371
2. Roth SY, Denu JM, Allis CD (2001) Histone acetyltransferases. Annu Rev Biochem
70:81–120
3. Lee KK, Workman JL (2007) Histone acetyltransferase complexes: one size doesn’t fit all. Nat
Rev Mol Cell Biol 8:284–295
4. Kalkhoven E (2004) CBP and p300: HATs for different occasions. Biochem Pharmacol
68:1145–1155
5. Wang R, Cherukuri P, Luo J (2005) Activation of Stat3 sequence-specific DNA binding and
transcription by p300/CREB-binding protein-mediated acetylation. J Biol Chem
280:11528–11534. https://doi.org/10.1074/jbc.M413930200
6. Sano Y, Ishii S (2001) Increased affinity of c-Myb for CREB-binding protein (CBP) after
CBP-induced acetylation. J Biol Chem 276:3674–3682. https://doi.org/10.1074/jbc.
M006896200
7. Chan HM, La Thangue NB (2001) p300/CBP proteins: HATs for transcriptional bridges and
scaffolds. J Cell Sci 114:2363–2373
8. di Martile M, del Bufalo D, Trisciuoglio D (2016) The multifaceted role of lysine acetylation
in cancer: prognostic biomarker and therapeutic target. Oncotarget 7:55789–55810. https://
doi.org/10.18632/oncotarget.10048
9. Esteller M (2008) Epigenetics in cancer. N Engl J Med 358:1148–1159. https://doi.org/10.
1056/NEJMra072067
10. Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, Fukamizu A (2005) Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl
Acad Sci U S A 102:11278–11283. https://doi.org/10.1073/pnas.0502738102
11. Dyda F, Klein DC, Hickman AB (2000) GCN5-related N-acetyltransferases: a structural
overview. Annu Rev Biophys Biomol Struct 29:81–103
12. Love IM, Sekaric P, Shi D, Grossman SR, Androphy EJ (2012) The histone acetyltransferase
PCAF regulates p21 transcription through stress-induced acetylation of histone H3. Cell Cycle
11:2458–2466
13. Kormendi V, Szyk A, Piszczek G, Roll-Mecak A (2012) Crystal structures of tubulin
acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N
terminus. J Biol Chem 287:41569–41575
14. Taschner M, Vetter M, Lorentzen E (2012) Atomic resolution structure of human α-tubulin
acetyltransferase bound to acetyl-CoA. Proc Natl Acad Sci U S A 109:19649–19654
15. Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R (2012) Structure of the
α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation. Proc
Natl Acad Sci U S A 109:19655–19660
16. Castro-Castro A, Janke C, Montagnac G, Paul-Gilloteaux P, Chavrier P (2012) ATAT1/MEC17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin
and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion. Eur J Cell
Biol 91:950–960
Histone Acetyltransferase Enzymes: From Biological Implications to Most. . .
115