52. Wang Y, Zhang R, Wu D, Lu Z, Sun W, Cai Y, Wang C, Jin J (2013) Epigenetic change in
kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell
carcinoma. J Exp Clin Cancer Res 32:8. https://doi.org/10.1186/1756-9966-32-8
53. Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B (2015) Expression of
hMOF in different ovarian tissues and its effects on ovarian cancer prognosis. Oncol Rep
33:685–692. https://doi.org/10.3892/or.2014.3649
54. Chen Z, Ye X, Tang N, Shen S, Li Z, Niu X, Lu S, Xu L (2014) The histone acetylranseferase
hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer.
Br J Pharmacol 171:3196–3211. https://doi.org/10.1111/bph.12661
55. Halkidou K, Gnanapragasam VJ, Mehta PB, Logan IR, Brady ME, Cook S, Leung HY, Neal
DE, Robson CN (2003) Expression of Tip60, an androgen receptor coactivator, and its role in
prostate cancer development. Oncogene 22:2466–2477
56. Bassi C, Li YT, Khu K, Mateo F, Baniasadi PS, Elia A, Mason J, Stambolic V, Pujana MA,
Mak TW, Gorrini C (2016) The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair. Cell Death Differ 23:1198–1208
57. Yin YW, Jin HJ, Zhao W, Gao B, Fang J, Wei J, Zhang DD, Zhang J, Fang D (2015) The
histone acetyltransferase GCN5 expression is elevated and regulated by c-Myc and E2F1
transcription factors in human colon cancer. Gene Expr 16:187–196
58. Li Q, Liu Z, Xu M, Xue Y, Yao B, Dou C, Jia Y, Wang Y, Tu K, Zheng X, Yao Y (2016)
PCAF inhibits hepatocellular carcinoma metastasis by inhibition of epithelial-mesenchymal
transition by targeting Gli-1. Cancer Lett 375:190–198
59. Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST,
Kipreos ET, Gaertig J (2010) MEC-17 is an alpha-tubulin acetyltransferase. Nature
467:218–222
60. Aguilar A, Becker L, Tedeschi T, Heller S, Iomini C, Nachury MV (2014) Α-tubulin K40
acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Mol
Biol Cell 25:1854–1866
61. Bailey JM, Alsina J, Rasheed ZA, McAllister FM, Fu YY, Plentz R, Zhang H, Pasricha PJ,
Bardeesy N, Matsui W, Maitra A, Leach SD (2014) DCLK1 marks a morphologically distinct
subpopulation of cells with stem cell properties in preinvasive pancreatic cancer. Gastroenterology 146:245–256
62. Park E, Kim Y, Ryu H, Kowall NW, Lee J, Ryu H (2014) Epigenetic mechanisms of
Rubinstein-Taybi syndrome. Neuromolecular Med 16:16–24. https://doi.org/10.1007/
s12017-013-8285-3
63. Wood MA, Kaplan MP, Park A, Blanchard EJ, Oliveira AM, Lombardi TL, Abel T (2005)
Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits
in hippocampal synaptic plasticity and memory storage. Learn Mem 12:111–119. https://doi.
org/10.1101/lm.86605
64. Phan HM, Xu AW, Coco C, Srajer G, Wyszomierski S, Evrard YA, Eckner R, Dent SY (2005)
GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn
233:1337–1347. https://doi.org/10.1002/dvdy.20445
65. Xu W, Edmondson DG, Evrard YA, Wakamiya M, Behringer RR, Roth SY (2000) Loss of
Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat
Genet 26:229–232. https://doi.org/10.1038/79973
66. Yamauchi T, Yamauchi J, Kuwata T, Tamura T, Yamashita T, Bae N, Westphal H, Ozato K,
Nakatani Y (2000) Distinct but overlapping roles of histone acetylase PCAF and of the closely
related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci U S A 97:11303–11306.
https://doi.org/10.1073/pnas.97.21.11303
67. Maurice T, Duclot F, Meunier J, Naert G, Givalois L, Meffre J, Celerier A, Jacquet C,
Copois V, Mechti N, Ozato K, Gongora C (2008) Altered memory capacities and response
to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice.
Neuropsychopharmacology 33:1584–1602. https://doi.org/10.1038/sj.npp.1301551
118
D. Trisciuoglio and D. Rotili
kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell
carcinoma. J Exp Clin Cancer Res 32:8. https://doi.org/10.1186/1756-9966-32-8
53. Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B (2015) Expression of
hMOF in different ovarian tissues and its effects on ovarian cancer prognosis. Oncol Rep
33:685–692. https://doi.org/10.3892/or.2014.3649
54. Chen Z, Ye X, Tang N, Shen S, Li Z, Niu X, Lu S, Xu L (2014) The histone acetylranseferase
hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer.
Br J Pharmacol 171:3196–3211. https://doi.org/10.1111/bph.12661
55. Halkidou K, Gnanapragasam VJ, Mehta PB, Logan IR, Brady ME, Cook S, Leung HY, Neal
DE, Robson CN (2003) Expression of Tip60, an androgen receptor coactivator, and its role in
prostate cancer development. Oncogene 22:2466–2477
56. Bassi C, Li YT, Khu K, Mateo F, Baniasadi PS, Elia A, Mason J, Stambolic V, Pujana MA,
Mak TW, Gorrini C (2016) The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair. Cell Death Differ 23:1198–1208
57. Yin YW, Jin HJ, Zhao W, Gao B, Fang J, Wei J, Zhang DD, Zhang J, Fang D (2015) The
histone acetyltransferase GCN5 expression is elevated and regulated by c-Myc and E2F1
transcription factors in human colon cancer. Gene Expr 16:187–196
58. Li Q, Liu Z, Xu M, Xue Y, Yao B, Dou C, Jia Y, Wang Y, Tu K, Zheng X, Yao Y (2016)
PCAF inhibits hepatocellular carcinoma metastasis by inhibition of epithelial-mesenchymal
transition by targeting Gli-1. Cancer Lett 375:190–198
59. Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST,
Kipreos ET, Gaertig J (2010) MEC-17 is an alpha-tubulin acetyltransferase. Nature
467:218–222
60. Aguilar A, Becker L, Tedeschi T, Heller S, Iomini C, Nachury MV (2014) Α-tubulin K40
acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Mol
Biol Cell 25:1854–1866
61. Bailey JM, Alsina J, Rasheed ZA, McAllister FM, Fu YY, Plentz R, Zhang H, Pasricha PJ,
Bardeesy N, Matsui W, Maitra A, Leach SD (2014) DCLK1 marks a morphologically distinct
subpopulation of cells with stem cell properties in preinvasive pancreatic cancer. Gastroenterology 146:245–256
62. Park E, Kim Y, Ryu H, Kowall NW, Lee J, Ryu H (2014) Epigenetic mechanisms of
Rubinstein-Taybi syndrome. Neuromolecular Med 16:16–24. https://doi.org/10.1007/
s12017-013-8285-3
63. Wood MA, Kaplan MP, Park A, Blanchard EJ, Oliveira AM, Lombardi TL, Abel T (2005)
Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits
in hippocampal synaptic plasticity and memory storage. Learn Mem 12:111–119. https://doi.
org/10.1101/lm.86605
64. Phan HM, Xu AW, Coco C, Srajer G, Wyszomierski S, Evrard YA, Eckner R, Dent SY (2005)
GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn
233:1337–1347. https://doi.org/10.1002/dvdy.20445
65. Xu W, Edmondson DG, Evrard YA, Wakamiya M, Behringer RR, Roth SY (2000) Loss of
Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat
Genet 26:229–232. https://doi.org/10.1038/79973
66. Yamauchi T, Yamauchi J, Kuwata T, Tamura T, Yamashita T, Bae N, Westphal H, Ozato K,
Nakatani Y (2000) Distinct but overlapping roles of histone acetylase PCAF and of the closely
related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci U S A 97:11303–11306.
https://doi.org/10.1073/pnas.97.21.11303
67. Maurice T, Duclot F, Meunier J, Naert G, Givalois L, Meffre J, Celerier A, Jacquet C,
Copois V, Mechti N, Ozato K, Gongora C (2008) Altered memory capacities and response
to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice.
Neuropsychopharmacology 33:1584–1602. https://doi.org/10.1038/sj.npp.1301551
118
D. Trisciuoglio and D. Rotili