of b-ketoacyl synthase I in entomopathogenic
bacteria (Photorhabdus luminescens subsp.
laumondii TT01). J Comput Sci Syst Biol
3:21–29
105. Akhurst RJ (1982) Antibiotic activity of
Xenorhabdus spp., bacteria symbiotically associated with insect pathogenic nematodes of
the families Heterorhabditidae and Steinernematidae. J Gen Microbiol 128:3061–3065
106. Khush RS, Lemaitre B (2000) Genes that
fight infection: what the Drosophila genome
says about animal immunity. Trends Genet
16:442–449
107. Chaston JM, Suen G, Tucker SL, Andersen
AW, Bhasin A, Bode E (2011) The entomopathogenic bacterial endosymbionts Xenorhabdus and Photorhabdus: convergent
lifestyles from divergent genomes. PLoS
One 6(11):e27909
108. Ogier J, Calteau A, Forst SJ, Blair H,
Roche D, Rouy Z, Suen G, Zumbihl R,
Givaudan A, Tailliez P, Me ´digue C, Gaudriault S (2010) Units of plasticity in bacterial
genomes: new insight from the comparative
genomics of two bacteria interacting with
invertebrates, Photorhabdus and Xenorhabdus.
BMC Genomics 11:568
109. Boemare NE, Boyer-Giglio MH, Thaler JO,
Akhurst RJ, Brehelin M (1992) Lysogeny and
bacteriocinogeny in Xenorhabdus nematophilus, and other Xenorhabdus spp. Appl Environ
Microbiol 58:3032–3037
110. Bo ¨szo ¨rme ´nyi E, Ersek T, Fodor A, Fodor
AM, Fo ¨ldes LS, Hevesi M, Hogan JS,
Katona Z, Klein MG, Korma ´ny A, Peka ´r S,
Szentirmai A, Sztaricskai F, Taylor RA (2009)
Isolation and activity of Xenorhabdus antimicrobial compounds against the plant pathogens Erwinia amylovora and Phytophthora
nicotianae. J Appl Microbiol 107:746–759
111. Xiao Q, Komori H, Lee CY (2012) Klumpfuss distinguishes stem cells from progenitor
cells during asymmetric neuroblast division.
Development 139(15):2670–2680
112. Fuchs MA, Sato K, Niedzwiecki D, Ye X, Saltz
LB, Mayer RJ et al (2014) Sugar-sweetened
beverage intake and cancer recurrence and
survival in CALGB 89803 (Alliance). PLoS
One 9(6):e99816
113. Tobias NJ, Heinrich AK, Eresmann H,
Wright PR, Neubacher N, Backofen R, Bode
HB (2017) Photorhabdus-nematode symbiosis is dependent on hfq-mediated regulation
of secondary metabolites. Environ Microbiol
19:119–129
114. Zhou Y, Chen C, Johansson MJ (2013) The
pre-mRNA retention and splicing complex
controls tRNA maturation by promoting
TAN1 expression. Nucleic Acids Res 41
(11):5669–5678
115. Bode GH, Coue ´ G, Freese C, Pickl KE, Sanchez-Purra ` M, Albaiges B, Borro ´ s S, van
Winden EC, Tziveleka LA, Sideratou Z,
Engbersen JFJ, Singh S, Albrecht K, Groll J,
Mo ¨ller M, Po ¨tgens AJG, Schmitz C,
Fro ¨hlich E, Grandfils C, Sinner FM, Kirkpatrick CJ, Steinbusch HWM, Frank HG,
Unger RE, Martinez-Martinez P (2017) An
in vitro and in vivo study of peptidefunctionalized nanoparticles for brain targeting: the importance of selective blood–brain
barrier uptake. Nanomed Nanotechnol Biol
Med 13:1289–1300
116. Reimer D, Luxenburger E, Brachmann AO,
Bode HB (2009) A new type of pyrrolidine
biosynthesis is involved in the late steps of
xenocoumacin production in Xenorhabdus
nematophila. Chembiochem 10:1997–2001
117. Sugar DR, Murfin KE, Chaston JM, Andersen AW, Richards GR, deLe ´on L (2012) Phenotypic variation and host interactions of
Xenorhabdus bovienii SS-2004, the entomopathogenic symbiont of Steinernema jollieti
nematodes. Environ Microbiol 14:924–939
118. Park HB, Perez CE, Perry EK, Crawford JM
(2016) Activating and attenuating the amicoumacin antibiotics. Molecules 21:E824
119. Reimer D, Nollmann FI, Schultz K, Kaiser M,
Bode HB (2014) Xenortide biosynthesis by
entomopathogenic Xenorhabdus nematophila. J Nat Prod 77:1976–1980
120. Hu MCT, Qiu WR, Wang X, Meyer CF, Tan
T-H (1996) Human HPK1, a novel human
hematopoietic progenitor kinase that activates
the JNK/SAPK kinase cascade. Genes Dev
10:2251–2264
121. Hu Y, Benedict MA, Ding L, Nu ´n ˜ez G (1999)
Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation
and apoptosis. EMBO J 18:3586–3595
122. Webster MS, Marra PP, Haig SM, Bensch S,
Holmes RT (2002) Links between worlds:
unraveling migratory connectivity. Trends
Ecol Evol 17:76–83
123. Gaugler R, Kaya HK (1990) Entomopathogenic nematodes in biological control. CRC
Press, Boca Raton, FL
124. Cutler GC, Webster JM (2003) Host-finding
ability of three entomopathogenic nematode
isolates in the presence of plant roots. Nematology 5(4):601–608
125. Glaser RW, Farrell CC (1935) Field experiments with the Japanese beetle and its nematode parasite. J N Y Entomol Soc. 43p
168
References
bacteria (Photorhabdus luminescens subsp.
laumondii TT01). J Comput Sci Syst Biol
3:21–29
105. Akhurst RJ (1982) Antibiotic activity of
Xenorhabdus spp., bacteria symbiotically associated with insect pathogenic nematodes of
the families Heterorhabditidae and Steinernematidae. J Gen Microbiol 128:3061–3065
106. Khush RS, Lemaitre B (2000) Genes that
fight infection: what the Drosophila genome
says about animal immunity. Trends Genet
16:442–449
107. Chaston JM, Suen G, Tucker SL, Andersen
AW, Bhasin A, Bode E (2011) The entomopathogenic bacterial endosymbionts Xenorhabdus and Photorhabdus: convergent
lifestyles from divergent genomes. PLoS
One 6(11):e27909
108. Ogier J, Calteau A, Forst SJ, Blair H,
Roche D, Rouy Z, Suen G, Zumbihl R,
Givaudan A, Tailliez P, Me ´digue C, Gaudriault S (2010) Units of plasticity in bacterial
genomes: new insight from the comparative
genomics of two bacteria interacting with
invertebrates, Photorhabdus and Xenorhabdus.
BMC Genomics 11:568
109. Boemare NE, Boyer-Giglio MH, Thaler JO,
Akhurst RJ, Brehelin M (1992) Lysogeny and
bacteriocinogeny in Xenorhabdus nematophilus, and other Xenorhabdus spp. Appl Environ
Microbiol 58:3032–3037
110. Bo ¨szo ¨rme ´nyi E, Ersek T, Fodor A, Fodor
AM, Fo ¨ldes LS, Hevesi M, Hogan JS,
Katona Z, Klein MG, Korma ´ny A, Peka ´r S,
Szentirmai A, Sztaricskai F, Taylor RA (2009)
Isolation and activity of Xenorhabdus antimicrobial compounds against the plant pathogens Erwinia amylovora and Phytophthora
nicotianae. J Appl Microbiol 107:746–759
111. Xiao Q, Komori H, Lee CY (2012) Klumpfuss distinguishes stem cells from progenitor
cells during asymmetric neuroblast division.
Development 139(15):2670–2680
112. Fuchs MA, Sato K, Niedzwiecki D, Ye X, Saltz
LB, Mayer RJ et al (2014) Sugar-sweetened
beverage intake and cancer recurrence and
survival in CALGB 89803 (Alliance). PLoS
One 9(6):e99816
113. Tobias NJ, Heinrich AK, Eresmann H,
Wright PR, Neubacher N, Backofen R, Bode
HB (2017) Photorhabdus-nematode symbiosis is dependent on hfq-mediated regulation
of secondary metabolites. Environ Microbiol
19:119–129
114. Zhou Y, Chen C, Johansson MJ (2013) The
pre-mRNA retention and splicing complex
controls tRNA maturation by promoting
TAN1 expression. Nucleic Acids Res 41
(11):5669–5678
115. Bode GH, Coue ´ G, Freese C, Pickl KE, Sanchez-Purra ` M, Albaiges B, Borro ´ s S, van
Winden EC, Tziveleka LA, Sideratou Z,
Engbersen JFJ, Singh S, Albrecht K, Groll J,
Mo ¨ller M, Po ¨tgens AJG, Schmitz C,
Fro ¨hlich E, Grandfils C, Sinner FM, Kirkpatrick CJ, Steinbusch HWM, Frank HG,
Unger RE, Martinez-Martinez P (2017) An
in vitro and in vivo study of peptidefunctionalized nanoparticles for brain targeting: the importance of selective blood–brain
barrier uptake. Nanomed Nanotechnol Biol
Med 13:1289–1300
116. Reimer D, Luxenburger E, Brachmann AO,
Bode HB (2009) A new type of pyrrolidine
biosynthesis is involved in the late steps of
xenocoumacin production in Xenorhabdus
nematophila. Chembiochem 10:1997–2001
117. Sugar DR, Murfin KE, Chaston JM, Andersen AW, Richards GR, deLe ´on L (2012) Phenotypic variation and host interactions of
Xenorhabdus bovienii SS-2004, the entomopathogenic symbiont of Steinernema jollieti
nematodes. Environ Microbiol 14:924–939
118. Park HB, Perez CE, Perry EK, Crawford JM
(2016) Activating and attenuating the amicoumacin antibiotics. Molecules 21:E824
119. Reimer D, Nollmann FI, Schultz K, Kaiser M,
Bode HB (2014) Xenortide biosynthesis by
entomopathogenic Xenorhabdus nematophila. J Nat Prod 77:1976–1980
120. Hu MCT, Qiu WR, Wang X, Meyer CF, Tan
T-H (1996) Human HPK1, a novel human
hematopoietic progenitor kinase that activates
the JNK/SAPK kinase cascade. Genes Dev
10:2251–2264
121. Hu Y, Benedict MA, Ding L, Nu ´n ˜ez G (1999)
Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation
and apoptosis. EMBO J 18:3586–3595
122. Webster MS, Marra PP, Haig SM, Bensch S,
Holmes RT (2002) Links between worlds:
unraveling migratory connectivity. Trends
Ecol Evol 17:76–83
123. Gaugler R, Kaya HK (1990) Entomopathogenic nematodes in biological control. CRC
Press, Boca Raton, FL
124. Cutler GC, Webster JM (2003) Host-finding
ability of three entomopathogenic nematode
isolates in the presence of plant roots. Nematology 5(4):601–608
125. Glaser RW, Farrell CC (1935) Field experiments with the Japanese beetle and its nematode parasite. J N Y Entomol Soc. 43p
168
References