50
D. Li et al.
42. Zhao M, Josephson L, Tang Y, Weissleder R (2003) Magnetic sensors for protease assays.
Angew Chem Int Ed Engl 42:1375–1378
43. Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L (2004) Magnetic relaxation
switch immunosensors detect enantiomeric impurities. Angew Chem Int Ed Engl 43:2395–
2399
44. Yigit MV, Mazumdar D, Kim H-K, Lee JH, Odintsov B, Lu Y (2007) Smart “Turn-on”
magnetic resonance contrast agents based on aptamer-functionalized superparamagnetic iron
oxide nanoparticles. ChemBioChem 8:1675–1678
45. Yigit MV, Mazumdar D, Lu Y (2008) MRI detection of thrombin with aptamer functionalized
superparamagnetic iron oxide nanoparticles. Bioconjug Chem 19:412–417
46. Kim B, Yang J, Hwang M, Choi J, Kim H-O, Jang E, Lee JH, Ryu S-H, Suh J-S, Huh Y-M,
Haam S (2013) Aptamer-modified magnetic nanoprobe for molecular MR imaging of VEGFR2
on angiogenic vasculature. Nanoscale Res Lett 8:399
47. You XG, Tu R, Peng ML, Bai YJ, Tan M, Li HJ, Guan J, Wen LJ (2014) Molecular magnetic
resonance probe targeting VEGF165: preparation and in vitro and in vivo evaluation. Contrast
Media Mol Imaging 9:349–354
48. Xu W, Lu Y (2011) A smart magnetic resonance imaging contrast agent responsive to adenosine
based on a DNA aptamer-conjugated gadolinium complex. Chem Commun (Camb) 47:4998–
5000
49. Jiang D, Im HJ, Boleyn ME, England CG, Ni D, Kang L, Engle JW, Huang P, Lan X, Cai
W (2019) Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative
evaluation of kidney function. Nano Res 12:637–642
50. Armanetti P, Pocovi-Martinez S, Flori A, Avigo C, Cassano D, Menichetti L, Voliani
V (2018) Dual photoacoustic/ultrasound multi-parametric imaging from passion fruit-like
nano-architectures. Nanomedicine 14:1787–1795
51. Rapoport N, Kennedy A, Shea J, Scaife C, Nam K-H (2009) Controlled and targeted
tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles. J Control Release
138:268–276
52. Zullino S, Argenziano M, Stura I, Guiot C, Cavalli R (2018) From micro- to nanomultifunctional theranostic platform: effective ultrasound imaging is not just a matter of scale.
Mol Imaging 17:1536012118778216
53. Wang CH, Huang YF, Yeh CK (2011) Aptamer-conjugated nanobubbles for targeted ultrasound
molecular imaging. Langmuir 27:6971–6976
54. Nakatsuka MA, Barback CV, Fitch KR, Farwell AR, Esener SC, Mattrey RF, Cha JN, Goodwin
AP (2013) In vivo ultrasound visualization of non-occlusive blood clots with thrombin-sensitive
contrast agents. Biomaterials 34:9559–9565
55. Wu M, Zhao H, Guo L, Wang Y, Song J, Zhao X, Li C, Hao L, Wang D, Tang J (2018)
Ultrasound-mediated nanobubble destruction (UMND) facilitates the delivery of A10-3.2
aptamer targeted and siRNA-loaded cationic nanobubbles for therapy of prostate cancer. Drug
Deliv 25:226–240
56. Kaufmann BA, Carr CL, Belcik JT, Xie A, Yue Q, Chadderdon S, Caplan ES, Khangura J,
Bullens S, Bunting S, Lindner JR (2010) Molecular imaging of the initial inflammatory response
in atherosclerosis: implications for early detection of disease. Arterioscler Thromb Vasc Biol
30:54–59
57. Li J, Lu Y (2000) A Highly Sensitive and Selective Catalytic DNA Biosensor for Lead Ions. J
Am Chem Soc 122
58. Wang AZ, Bagalkot V, Vasilliou CC, Gu F, Alexis F, Zhang L et al (2008) Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging
and therapy. ChemMedChem 3:1311–1315
59. Blum G, von Degenfeld G, Merchant MJ, Blau HM, Bogyo M (2007) Noninvasive optical
imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nat
Chem Biol 3:668–677
60. Navani N, Li Y (2006) Nucleic acid aptamers and enzymes as sensors. Curr Opin Chem Biol
10:272–281
D. Li et al.
42. Zhao M, Josephson L, Tang Y, Weissleder R (2003) Magnetic sensors for protease assays.
Angew Chem Int Ed Engl 42:1375–1378
43. Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L (2004) Magnetic relaxation
switch immunosensors detect enantiomeric impurities. Angew Chem Int Ed Engl 43:2395–
2399
44. Yigit MV, Mazumdar D, Kim H-K, Lee JH, Odintsov B, Lu Y (2007) Smart “Turn-on”
magnetic resonance contrast agents based on aptamer-functionalized superparamagnetic iron
oxide nanoparticles. ChemBioChem 8:1675–1678
45. Yigit MV, Mazumdar D, Lu Y (2008) MRI detection of thrombin with aptamer functionalized
superparamagnetic iron oxide nanoparticles. Bioconjug Chem 19:412–417
46. Kim B, Yang J, Hwang M, Choi J, Kim H-O, Jang E, Lee JH, Ryu S-H, Suh J-S, Huh Y-M,
Haam S (2013) Aptamer-modified magnetic nanoprobe for molecular MR imaging of VEGFR2
on angiogenic vasculature. Nanoscale Res Lett 8:399
47. You XG, Tu R, Peng ML, Bai YJ, Tan M, Li HJ, Guan J, Wen LJ (2014) Molecular magnetic
resonance probe targeting VEGF165: preparation and in vitro and in vivo evaluation. Contrast
Media Mol Imaging 9:349–354
48. Xu W, Lu Y (2011) A smart magnetic resonance imaging contrast agent responsive to adenosine
based on a DNA aptamer-conjugated gadolinium complex. Chem Commun (Camb) 47:4998–
5000
49. Jiang D, Im HJ, Boleyn ME, England CG, Ni D, Kang L, Engle JW, Huang P, Lan X, Cai
W (2019) Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative
evaluation of kidney function. Nano Res 12:637–642
50. Armanetti P, Pocovi-Martinez S, Flori A, Avigo C, Cassano D, Menichetti L, Voliani
V (2018) Dual photoacoustic/ultrasound multi-parametric imaging from passion fruit-like
nano-architectures. Nanomedicine 14:1787–1795
51. Rapoport N, Kennedy A, Shea J, Scaife C, Nam K-H (2009) Controlled and targeted
tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles. J Control Release
138:268–276
52. Zullino S, Argenziano M, Stura I, Guiot C, Cavalli R (2018) From micro- to nanomultifunctional theranostic platform: effective ultrasound imaging is not just a matter of scale.
Mol Imaging 17:1536012118778216
53. Wang CH, Huang YF, Yeh CK (2011) Aptamer-conjugated nanobubbles for targeted ultrasound
molecular imaging. Langmuir 27:6971–6976
54. Nakatsuka MA, Barback CV, Fitch KR, Farwell AR, Esener SC, Mattrey RF, Cha JN, Goodwin
AP (2013) In vivo ultrasound visualization of non-occlusive blood clots with thrombin-sensitive
contrast agents. Biomaterials 34:9559–9565
55. Wu M, Zhao H, Guo L, Wang Y, Song J, Zhao X, Li C, Hao L, Wang D, Tang J (2018)
Ultrasound-mediated nanobubble destruction (UMND) facilitates the delivery of A10-3.2
aptamer targeted and siRNA-loaded cationic nanobubbles for therapy of prostate cancer. Drug
Deliv 25:226–240
56. Kaufmann BA, Carr CL, Belcik JT, Xie A, Yue Q, Chadderdon S, Caplan ES, Khangura J,
Bullens S, Bunting S, Lindner JR (2010) Molecular imaging of the initial inflammatory response
in atherosclerosis: implications for early detection of disease. Arterioscler Thromb Vasc Biol
30:54–59
57. Li J, Lu Y (2000) A Highly Sensitive and Selective Catalytic DNA Biosensor for Lead Ions. J
Am Chem Soc 122
58. Wang AZ, Bagalkot V, Vasilliou CC, Gu F, Alexis F, Zhang L et al (2008) Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging
and therapy. ChemMedChem 3:1311–1315
59. Blum G, von Degenfeld G, Merchant MJ, Blau HM, Bogyo M (2007) Noninvasive optical
imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nat
Chem Biol 3:668–677
60. Navani N, Li Y (2006) Nucleic acid aptamers and enzymes as sensors. Curr Opin Chem Biol
10:272–281