2 Aptamer-Based Probes for Molecular Imaging
51
61. Hama Y, Urano Y, Koyama Y, Kamiya M, Bernardo M, Paik RS, Shin IS, Paik CH, Choyke PL,
Kobayashi H (2007) A target cell-specific activatable fluorescence probe for in vivo molecular
imaging of cancer based on a self-quenched avidin-rhodamine conjugate. Cancer Res 67:2791–
2799
62. Lu Y (2002) New transition-metal-dependent DNAzymes as efficient endonucleases and as
selective metal biosensors. Chemistry 8:4589–4596
63. Theodorou I, Nguyen Quang N, Gombert K, Thézé B, Lelandais B, Ducongè F (2016) In vitro
and in vivo imaging of fluorescent aptamers 1380:135–150
64. Napp J, Mathejczyk JE, Alves F (2011) Optical imaging in vivo with a focus on paediatric
disease: technical progress, current preclinical and clinical applications and future perspectives.
Pediatr Radiol 41:161–175
65. Shi H, He X, Cui W, Wang K, Deng K, Li D, Xu F (2014) Locked nucleic acid/DNA chimeric
aptamer probe for tumor diagnosis with improved serum stability and extended imaging window
in vivo. Anal Chim Acta 812:138–144
66. Shi H, Tang Z, Kim Y, Nie H, Huang YF, He X, Deng K, Wang K, Tan W (2010) In vivo
fluorescence imaging of tumors using molecular aptamers generated by cell-SELEX. Chem
Asian J 5:2209–2213
67. Gong P, Shi B, Zheng M, Wang B, Zhang P, Hu D, Gao D, Sheng Z, Zheng C, Ma Y, Cai L
(2012) PEI protected aptamer molecular probes for contrast-enhanced in vivo cancer imaging.
Biomaterials 33:7810–7817
68. Calzada V, Moreno M, Newton J, Gonzalez J, Fernandez M, Gambini JP, Ibarra M, Chabalgoity A, Deutscher S, Quinn T, Cabral P, Cerecetto H (2017) Development of new PTK7targeting aptamer-fluorescent and radiolabelled probes for evaluation as molecular imaging
agents: Lymphoma and melanoma in vivo proof of concept. Bioorg Med Chem 25:1163–1171
69. Genevois C, Loiseau H, Couillaud F (2016) In vivo follow-up of brain tumor growth via
bioluminescence imaging and fluorescence tomography. Int J Mol Sci 17:1815
70. Cibiel A, Quang NN, Gombert K, Theze B, Garofalakis A, Duconge F (2014) From ugly
duckling to swan: unexpected identification from cell-SELEX of an anti-Annexin A2 aptamer
targeting tumors. PLoS One 9:e87002
71. Garofalakis A, Dubois A, Kuhnast B, Dupont DM, Janssens I, Mackiewicz N, Dolle F, Tavitian
B, Duconge F (2010) In vivo validation of free-space fluorescence tomography using nuclear
imaging. Opt Lett 35:3024–3026
72. Shi H, He X, Wang K, Wu X, Ye X, Guo Q, Tan W, Qing Z, Yang X, Zhou B (2011) Activatable
aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane proteintriggered conformation alteration. Proc Natl Acad Sci USA 108:3900–3905
73. Li C, Meng Y, Wang S, Qian M, Wang J, Lu W, Huang R (2015) Mesoporous carbon nanospheres
featured fluorescent aptasensor for multiple diagnosis of cancer in vitro and in vivo. ACS Nano
9:12096–12103
74. Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT (2014) RNA aptamer probes as
optical imaging agents for the detection of amyloid plaques. PLoS One 9:e89901
75. Simao T, Ng A, Fatehi D, Corluka S, Abulrob A, Zourob M (2015) Development of an antivascular cell adhesion protein-1 aptamer for molecular imaging and inflammation detection in
transgenic mouse model of Alzheimer’s disease. J Biomed Nanotechnol 11:2264–2274
76. Lazarova N, Causey PW, Lemon JA, Czorny SK, Forbes JR, Zlitni A, Genady A, Foster
FS, Valliant JF (2011) The synthesis, magnetic purification and evaluation of 99mTc-labeled
microbubbles. Nucl Med Biol 38:1111–1118
77. Li M, Wang Y, Liu M, Lan X (2018) Multimodality reporter gene imaging: construction
strategies and application. Theranostics 8:2954–2973
78. Yanagisawa K, Moriyasu F, Miyahara T, Yuki M, Iijima H (2007) Phagocytosis of ultrasound
contrast agent microbubbles by Kupffer cells. Ultrasound Med Biol 33:318–325
79. Chu TC, Shieh F, Lavery LA, Levy M, Richards-Kortum R, Korgel BA, Ellington AD (2006)
Labeling tumor cells with fluorescent nanocrystal-aptamer bioconjugates. Biosens Bioelectron
21:1859–1866
51
61. Hama Y, Urano Y, Koyama Y, Kamiya M, Bernardo M, Paik RS, Shin IS, Paik CH, Choyke PL,
Kobayashi H (2007) A target cell-specific activatable fluorescence probe for in vivo molecular
imaging of cancer based on a self-quenched avidin-rhodamine conjugate. Cancer Res 67:2791–
2799
62. Lu Y (2002) New transition-metal-dependent DNAzymes as efficient endonucleases and as
selective metal biosensors. Chemistry 8:4589–4596
63. Theodorou I, Nguyen Quang N, Gombert K, Thézé B, Lelandais B, Ducongè F (2016) In vitro
and in vivo imaging of fluorescent aptamers 1380:135–150
64. Napp J, Mathejczyk JE, Alves F (2011) Optical imaging in vivo with a focus on paediatric
disease: technical progress, current preclinical and clinical applications and future perspectives.
Pediatr Radiol 41:161–175
65. Shi H, He X, Cui W, Wang K, Deng K, Li D, Xu F (2014) Locked nucleic acid/DNA chimeric
aptamer probe for tumor diagnosis with improved serum stability and extended imaging window
in vivo. Anal Chim Acta 812:138–144
66. Shi H, Tang Z, Kim Y, Nie H, Huang YF, He X, Deng K, Wang K, Tan W (2010) In vivo
fluorescence imaging of tumors using molecular aptamers generated by cell-SELEX. Chem
Asian J 5:2209–2213
67. Gong P, Shi B, Zheng M, Wang B, Zhang P, Hu D, Gao D, Sheng Z, Zheng C, Ma Y, Cai L
(2012) PEI protected aptamer molecular probes for contrast-enhanced in vivo cancer imaging.
Biomaterials 33:7810–7817
68. Calzada V, Moreno M, Newton J, Gonzalez J, Fernandez M, Gambini JP, Ibarra M, Chabalgoity A, Deutscher S, Quinn T, Cabral P, Cerecetto H (2017) Development of new PTK7targeting aptamer-fluorescent and radiolabelled probes for evaluation as molecular imaging
agents: Lymphoma and melanoma in vivo proof of concept. Bioorg Med Chem 25:1163–1171
69. Genevois C, Loiseau H, Couillaud F (2016) In vivo follow-up of brain tumor growth via
bioluminescence imaging and fluorescence tomography. Int J Mol Sci 17:1815
70. Cibiel A, Quang NN, Gombert K, Theze B, Garofalakis A, Duconge F (2014) From ugly
duckling to swan: unexpected identification from cell-SELEX of an anti-Annexin A2 aptamer
targeting tumors. PLoS One 9:e87002
71. Garofalakis A, Dubois A, Kuhnast B, Dupont DM, Janssens I, Mackiewicz N, Dolle F, Tavitian
B, Duconge F (2010) In vivo validation of free-space fluorescence tomography using nuclear
imaging. Opt Lett 35:3024–3026
72. Shi H, He X, Wang K, Wu X, Ye X, Guo Q, Tan W, Qing Z, Yang X, Zhou B (2011) Activatable
aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane proteintriggered conformation alteration. Proc Natl Acad Sci USA 108:3900–3905
73. Li C, Meng Y, Wang S, Qian M, Wang J, Lu W, Huang R (2015) Mesoporous carbon nanospheres
featured fluorescent aptasensor for multiple diagnosis of cancer in vitro and in vivo. ACS Nano
9:12096–12103
74. Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT (2014) RNA aptamer probes as
optical imaging agents for the detection of amyloid plaques. PLoS One 9:e89901
75. Simao T, Ng A, Fatehi D, Corluka S, Abulrob A, Zourob M (2015) Development of an antivascular cell adhesion protein-1 aptamer for molecular imaging and inflammation detection in
transgenic mouse model of Alzheimer’s disease. J Biomed Nanotechnol 11:2264–2274
76. Lazarova N, Causey PW, Lemon JA, Czorny SK, Forbes JR, Zlitni A, Genady A, Foster
FS, Valliant JF (2011) The synthesis, magnetic purification and evaluation of 99mTc-labeled
microbubbles. Nucl Med Biol 38:1111–1118
77. Li M, Wang Y, Liu M, Lan X (2018) Multimodality reporter gene imaging: construction
strategies and application. Theranostics 8:2954–2973
78. Yanagisawa K, Moriyasu F, Miyahara T, Yuki M, Iijima H (2007) Phagocytosis of ultrasound
contrast agent microbubbles by Kupffer cells. Ultrasound Med Biol 33:318–325
79. Chu TC, Shieh F, Lavery LA, Levy M, Richards-Kortum R, Korgel BA, Ellington AD (2006)
Labeling tumor cells with fluorescent nanocrystal-aptamer bioconjugates. Biosens Bioelectron
21:1859–1866