2 Aptamer-Based Probes for Molecular Imaging
49
22. Ferreira CS, Matthews CS, Missailidis S (2006) DNA aptamers that bind to MUC1 tumour
marker: design and characterization of MUC1-binding single-stranded DNA aptamers. Tumour
Biol 27:289–301
23. Pieve CD, Perkins AC, Missailidis S (2009) Anti-MUC1 aptamers: radiolabelling with (99 m)Tc
and biodistribution in MCF-7 tumour-bearing mice. Nucl Med Biol 36:703–710
24. Sá LTM, Simmons S, Missailidis S, Silva MIPD, Santos-Oliveira R (2013) Aptamer-based
nanoparticles for cancer targeting. J Drug Target 21:427–434
25. Abadía F, Torreblanca J, García-Herdugo G, Moreno F (1998) Inhibition of nucleolar protein
nucleolin by electroporation with anti-nucleolin antibodies results in an increase of the nucleolar
size. Biol Cell/Under Auspices Eur Cell Biol Organ 90:355–361
26. Bates PJ, Kahlon JB, Thomas SD, Trent JO, Miller DM (1999) Antiproliferative activity of
G-rich oligonucleotides correlates with protein binding. J Biol Chem 274:26369–26377
27. Noaparast Z, Hosseinimehr SJ, Piramoon M, Abedi SM (2015) Tumor targeting with a 99 mTclabeled AS1411 aptamer in prostate tumor cells. J Drug Target 23:497–505
28. Gomes SDR, Miguel J, Azéma L, Eimer S, Toulme JJ (2012) Tc-99 m-MAG3-Aptamer for
Imaging Human Tumors Associated with High Level of Matrix Metalloprotease-9. Bioconjug
Chem 23:2192–2200
29. Kryza D, Debordeaux F, Azéma L, Hassan A, Paurelle O, Schulz J, others (2016) Ex vivo and
in vivo imaging and biodistribution of aptamers targeting the human matrix MetalloProtease-9
in melanomas. Plos One 11:e0149387
30. Cao X, Li S, Chen L, Ding H, Xu H, Huang Y, Li J, Liu N, Cao W, Zhu Y (2009) Combining
use of a panel of ssDNA aptamers in the detection of Staphylococcus aureus. Nucleic Acids
Res 37:4621–4628
31. Correa CR, Barros ALBD, Ferreira CDA, Goes AMD, Cardoso VN, Andrade ASRD (2014)
Aptamers directly radiolabeled with technetium-99 m as a potential agent capable of identifying
carcinoembryonic antigen (CEA) in tumor cells T84. Bioorg Med Chem Lett 24:1998–2001
32. Dos Santos SR, Rodrigues Corrêa C, Branco De Barros AL, Serakides R, Fernandes SO,
Cardoso VN, De Andrade ASR (2015) Identification of Staphylococcus aureus infection by
aptamers directly radiolabeled with technetium-99m. Nucl Med Biol 42:292–298
33. Hwang DW, Ko HY, Lee JH, Kang H, Ryu SH, Song IC, Lee DS, Kim S (2010) A nucleolintargeted multimodal nanoparticle imaging probe for tracking cancer cells using an aptamer. J
Nucl Med 51:98–105
34. Li J, Zheng H, Bates PJ, Malik T, Li XF, Trent JO, Ng CK (2014) Aptamer imaging with Cu-64
labeled AS1411: preliminary assessment in lung cancer. Nucl Med Biol 41:179–185
35. Park JY, Lee TS, Song IH, Cho YL, Chae JR, Yun M, Kang H, Lee JH, Lim JH, Cho WG,
Kang WJ (2016) Hybridization-based aptamer labeling using complementary oligonucleotide
platform for PET and optical imaging. Biomaterials 100:143–151
36. Boisgard R, Kuhnast B, Jego B, Siquier K, Hinnen F, Dolle F, Friebe M, Borkowski S, Dinkelborg L, Tavitian B (2009) In vivo PET tumour imaging using an [F-18] labelled aptamer
targeting tenascin-C. J Nucl Med 50:1594
37. Jacobson O, Yan X, Niu G, Weiss ID, Ma Y, Szajek LP, Shen B, Kiesewetter DO, Chen X
(2015) PET imaging of tenascin-C with a radiolabeled single-stranded DNA aptamer. J Nucl
Med 56:616–621
38. Hu H, Dai A, Sun J, Li X, Gao F, Wu L, Fang Y, Yang H, An L, Wu H, Yang S (2013) Aptamerconjugated Mn 3 O 4 @SiO 2 core-shell nanoprobes for targeted magnetic resonance imaging.
Nanoscale 5:10447–10454
39. Lim EK, Kim B, Choi Y, Ro Y, Cho EJ, Lee JH, Ryu SH, Suh JS, Haam S, Huh YM (2014)
Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin alpha
v beta 3 via magnetic resonance imaging. J Biomed Mater Res A 102:49–59
40. Josephson L, Perez JM, Weissleder R (2001) Magnetic nanosensors for the detection of
oligonucleotide sequences. Angew Chem Int Ed Engl 40:3204–3206
41. Perez JM, Josephson L, O’Loughlin T, Hogemann D, Weissleder R (2002) Magnetic relaxation
switches capable of sensing molecular interactions. Nat Biotechnol 20:816–820
49
22. Ferreira CS, Matthews CS, Missailidis S (2006) DNA aptamers that bind to MUC1 tumour
marker: design and characterization of MUC1-binding single-stranded DNA aptamers. Tumour
Biol 27:289–301
23. Pieve CD, Perkins AC, Missailidis S (2009) Anti-MUC1 aptamers: radiolabelling with (99 m)Tc
and biodistribution in MCF-7 tumour-bearing mice. Nucl Med Biol 36:703–710
24. Sá LTM, Simmons S, Missailidis S, Silva MIPD, Santos-Oliveira R (2013) Aptamer-based
nanoparticles for cancer targeting. J Drug Target 21:427–434
25. Abadía F, Torreblanca J, García-Herdugo G, Moreno F (1998) Inhibition of nucleolar protein
nucleolin by electroporation with anti-nucleolin antibodies results in an increase of the nucleolar
size. Biol Cell/Under Auspices Eur Cell Biol Organ 90:355–361
26. Bates PJ, Kahlon JB, Thomas SD, Trent JO, Miller DM (1999) Antiproliferative activity of
G-rich oligonucleotides correlates with protein binding. J Biol Chem 274:26369–26377
27. Noaparast Z, Hosseinimehr SJ, Piramoon M, Abedi SM (2015) Tumor targeting with a 99 mTclabeled AS1411 aptamer in prostate tumor cells. J Drug Target 23:497–505
28. Gomes SDR, Miguel J, Azéma L, Eimer S, Toulme JJ (2012) Tc-99 m-MAG3-Aptamer for
Imaging Human Tumors Associated with High Level of Matrix Metalloprotease-9. Bioconjug
Chem 23:2192–2200
29. Kryza D, Debordeaux F, Azéma L, Hassan A, Paurelle O, Schulz J, others (2016) Ex vivo and
in vivo imaging and biodistribution of aptamers targeting the human matrix MetalloProtease-9
in melanomas. Plos One 11:e0149387
30. Cao X, Li S, Chen L, Ding H, Xu H, Huang Y, Li J, Liu N, Cao W, Zhu Y (2009) Combining
use of a panel of ssDNA aptamers in the detection of Staphylococcus aureus. Nucleic Acids
Res 37:4621–4628
31. Correa CR, Barros ALBD, Ferreira CDA, Goes AMD, Cardoso VN, Andrade ASRD (2014)
Aptamers directly radiolabeled with technetium-99 m as a potential agent capable of identifying
carcinoembryonic antigen (CEA) in tumor cells T84. Bioorg Med Chem Lett 24:1998–2001
32. Dos Santos SR, Rodrigues Corrêa C, Branco De Barros AL, Serakides R, Fernandes SO,
Cardoso VN, De Andrade ASR (2015) Identification of Staphylococcus aureus infection by
aptamers directly radiolabeled with technetium-99m. Nucl Med Biol 42:292–298
33. Hwang DW, Ko HY, Lee JH, Kang H, Ryu SH, Song IC, Lee DS, Kim S (2010) A nucleolintargeted multimodal nanoparticle imaging probe for tracking cancer cells using an aptamer. J
Nucl Med 51:98–105
34. Li J, Zheng H, Bates PJ, Malik T, Li XF, Trent JO, Ng CK (2014) Aptamer imaging with Cu-64
labeled AS1411: preliminary assessment in lung cancer. Nucl Med Biol 41:179–185
35. Park JY, Lee TS, Song IH, Cho YL, Chae JR, Yun M, Kang H, Lee JH, Lim JH, Cho WG,
Kang WJ (2016) Hybridization-based aptamer labeling using complementary oligonucleotide
platform for PET and optical imaging. Biomaterials 100:143–151
36. Boisgard R, Kuhnast B, Jego B, Siquier K, Hinnen F, Dolle F, Friebe M, Borkowski S, Dinkelborg L, Tavitian B (2009) In vivo PET tumour imaging using an [F-18] labelled aptamer
targeting tenascin-C. J Nucl Med 50:1594
37. Jacobson O, Yan X, Niu G, Weiss ID, Ma Y, Szajek LP, Shen B, Kiesewetter DO, Chen X
(2015) PET imaging of tenascin-C with a radiolabeled single-stranded DNA aptamer. J Nucl
Med 56:616–621
38. Hu H, Dai A, Sun J, Li X, Gao F, Wu L, Fang Y, Yang H, An L, Wu H, Yang S (2013) Aptamerconjugated Mn 3 O 4 @SiO 2 core-shell nanoprobes for targeted magnetic resonance imaging.
Nanoscale 5:10447–10454
39. Lim EK, Kim B, Choi Y, Ro Y, Cho EJ, Lee JH, Ryu SH, Suh JS, Haam S, Huh YM (2014)
Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin alpha
v beta 3 via magnetic resonance imaging. J Biomed Mater Res A 102:49–59
40. Josephson L, Perez JM, Weissleder R (2001) Magnetic nanosensors for the detection of
oligonucleotide sequences. Angew Chem Int Ed Engl 40:3204–3206
41. Perez JM, Josephson L, O’Loughlin T, Hogemann D, Weissleder R (2002) Magnetic relaxation
switches capable of sensing molecular interactions. Nat Biotechnol 20:816–820