12 Aptamers for the Diagnosis and Therapy …
371
48. Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT (2014) RNA aptamer probes as
optical imaging agents for the detection of amyloid plaques. PLoS ONE 9(2):e89901. https://
doi.org/10.1371/journal.pone.0089901
49. Rahimi F, Murakami K, Summers JL, Chen CH, Bitan G (2009) RNA aptamers generated
against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but
high sensitivity. PLoS ONE 4(11):e7694. https://doi.org/10.1371/journal.pone.0007694
50. Zhu L, Zhang J, Wang F, Wang Y, Lu L, Feng C, Xu Z, Zhang W (2016) Selective amyloid
beta oligomer assay based on abasic site-containing molecular beacon and enzyme-free
amplification. Biosens Bioelectron 78:206–212. https://doi.org/10.1016/j.bios.2015.11.048
51. Rahimi F, Bitan G (2010) Selection of aptamers for amyloid beta-protein, the causative agent
of Alzheimer’s disease. J Vis Exp JoVE (39). https://doi.org/10.3791/1955
52. Tsukakoshi K, Abe K, Sode K, Ikebukuro K (2012) Selection of DNA aptamers that recognize
alpha-synuclein oligomers using a competitive screening method. Anal Chem 84(13):5542–
5547. https://doi.org/10.1021/ac300330g
53. Chakravarthy M, AlShamaileh H, Huang H, Tannenberg RK, Chen S, Worrall S, Dodd PR,
Veedu RN (2018) Development of DNA aptamers targeting low-molecular-weight amyloidbeta peptide aggregates in vitro. Chem Commun 54(36):4593–4596. https://doi.org/10.1039/
c8cc02256a
54. Murakami K, Obata Y, Sekikawa A, Ueda H, Izuo N, Awano T, Takabe K, Shimizu T, Irie K
(2020) An RNA aptamer with potent affinity for a toxic dimer of amyloid beta42 has potential
utility for histochemical studies of Alzheimer’s disease. J Biol Chem. https://doi.org/10.1074/
jbc.RA119.010955
55. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S (2016) Visualizing APP
and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat
Neurosci 19(1):55–64. https://doi.org/10.1038/nn.4188
56. Liang H, Shi Y, Kou Z, Peng Y, Chen W, Li X, Li S, Wang Y, Wang F, Zhang X (2015)
Inhibition of BACE1 activity by a DNA aptamer in an Alzheimer’s disease cell model. PLoS
ONE 10(10):e0140733. https://doi.org/10.1371/journal.pone.0140733
57. Rentmeister A, Bill A, Wahle T, Walter J, Famulok M (2006) RNA aptamers selectively
modulate protein recruitment to the cytoplasmic domain of beta-secretase BACE1 in vitro.
RNA 12(9):1650–1660. https://doi.org/10.1261/rna.126306
58. Lauren J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM (2009) Cellular prion
protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature
457(7233):1128–1132. https://doi.org/10.1038/nature07761
59. Guo JL, Lee VM (2011) Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles. J Biol Chem 286(17):15317–15331. https://doi.org/10.
1074/jbc.M110.209296
60. Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C,
Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg
CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso
J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman
BT (2018) Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease. Neuron
99 (5):925–940 e927. https://doi.org/10.1016/j.neuron.2018.07.039
61. Krylova SM, Musheev M, Nutiu R, Li Y, Lee G, Krylov SN (2005) Tau protein binds singlestranded DNA sequence specifically–the proof obtained in vitro with non-equilibrium capillary electrophoresis of equilibrium mixtures. FEBS Lett 579(6):1371–1375. https://doi.org/
10.1016/j.febslet.2005.01.032
62. Kim S, Wark AW, Lee HJ (2016) Femtomolar detection of tau proteins in undiluted plasma
using surface plasmon resonance. Anal Chem 88(15):7793–7799. https://doi.org/10.1021/acs.
analchem.6b01825
63. Ziu I, Laryea ET, Alashkar F, Wu CG, Martic S (2020) A dip-and-read optical aptasensor for
detection of tau protein. Anal Bioanal Chem 412(5):1193–1201. https://doi.org/10.1007/s00
216-019-02350-8
371
48. Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT (2014) RNA aptamer probes as
optical imaging agents for the detection of amyloid plaques. PLoS ONE 9(2):e89901. https://
doi.org/10.1371/journal.pone.0089901
49. Rahimi F, Murakami K, Summers JL, Chen CH, Bitan G (2009) RNA aptamers generated
against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but
high sensitivity. PLoS ONE 4(11):e7694. https://doi.org/10.1371/journal.pone.0007694
50. Zhu L, Zhang J, Wang F, Wang Y, Lu L, Feng C, Xu Z, Zhang W (2016) Selective amyloid
beta oligomer assay based on abasic site-containing molecular beacon and enzyme-free
amplification. Biosens Bioelectron 78:206–212. https://doi.org/10.1016/j.bios.2015.11.048
51. Rahimi F, Bitan G (2010) Selection of aptamers for amyloid beta-protein, the causative agent
of Alzheimer’s disease. J Vis Exp JoVE (39). https://doi.org/10.3791/1955
52. Tsukakoshi K, Abe K, Sode K, Ikebukuro K (2012) Selection of DNA aptamers that recognize
alpha-synuclein oligomers using a competitive screening method. Anal Chem 84(13):5542–
5547. https://doi.org/10.1021/ac300330g
53. Chakravarthy M, AlShamaileh H, Huang H, Tannenberg RK, Chen S, Worrall S, Dodd PR,
Veedu RN (2018) Development of DNA aptamers targeting low-molecular-weight amyloidbeta peptide aggregates in vitro. Chem Commun 54(36):4593–4596. https://doi.org/10.1039/
c8cc02256a
54. Murakami K, Obata Y, Sekikawa A, Ueda H, Izuo N, Awano T, Takabe K, Shimizu T, Irie K
(2020) An RNA aptamer with potent affinity for a toxic dimer of amyloid beta42 has potential
utility for histochemical studies of Alzheimer’s disease. J Biol Chem. https://doi.org/10.1074/
jbc.RA119.010955
55. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S (2016) Visualizing APP
and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat
Neurosci 19(1):55–64. https://doi.org/10.1038/nn.4188
56. Liang H, Shi Y, Kou Z, Peng Y, Chen W, Li X, Li S, Wang Y, Wang F, Zhang X (2015)
Inhibition of BACE1 activity by a DNA aptamer in an Alzheimer’s disease cell model. PLoS
ONE 10(10):e0140733. https://doi.org/10.1371/journal.pone.0140733
57. Rentmeister A, Bill A, Wahle T, Walter J, Famulok M (2006) RNA aptamers selectively
modulate protein recruitment to the cytoplasmic domain of beta-secretase BACE1 in vitro.
RNA 12(9):1650–1660. https://doi.org/10.1261/rna.126306
58. Lauren J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM (2009) Cellular prion
protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature
457(7233):1128–1132. https://doi.org/10.1038/nature07761
59. Guo JL, Lee VM (2011) Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles. J Biol Chem 286(17):15317–15331. https://doi.org/10.
1074/jbc.M110.209296
60. Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C,
Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg
CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso
J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman
BT (2018) Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease. Neuron
99 (5):925–940 e927. https://doi.org/10.1016/j.neuron.2018.07.039
61. Krylova SM, Musheev M, Nutiu R, Li Y, Lee G, Krylov SN (2005) Tau protein binds singlestranded DNA sequence specifically–the proof obtained in vitro with non-equilibrium capillary electrophoresis of equilibrium mixtures. FEBS Lett 579(6):1371–1375. https://doi.org/
10.1016/j.febslet.2005.01.032
62. Kim S, Wark AW, Lee HJ (2016) Femtomolar detection of tau proteins in undiluted plasma
using surface plasmon resonance. Anal Chem 88(15):7793–7799. https://doi.org/10.1021/acs.
analchem.6b01825
63. Ziu I, Laryea ET, Alashkar F, Wu CG, Martic S (2020) A dip-and-read optical aptasensor for
detection of tau protein. Anal Bioanal Chem 412(5):1193–1201. https://doi.org/10.1007/s00
216-019-02350-8