3.4.3 Gallium-67
Scasnar et al. prepared a series of sulfophthalocyanines (PcS) labeled with
67 Ga and
studied the effect of the degree of sulfonation on biodistribution [10]. They suggested that lesser sulfonated
67 GaPcS, which had significant binding with the
various lipoprotein fractions, should be explored for PDT for cancer, whereas
increased sulfonation favored association to albumin and suitable for tumor
imaging. The same group studied the biodistribution and tumor uptake of
67 Ga-labeled lipophilic Ga-TOPc and amphiphilic Ga-TOPcS in tumor bearing
C3H mice [83]. The amphiphilic
67 Ga-TOPcS exhibited promising tumor uptake
and tissue distribution pattern compared to the highly lipophilic
67 Ga-TOPc.
N
N
N
N
N
N
N
N
Ga
R
R
R
R
Cl
R = OC 18 H 37
N
N
N
N
N
N
N
N
Ga
R
R
R
R
OH
R = OC 18 H 37 , X = H or SO 3
-
X
X
X
X
32a
32b
3.4.4 Technetium-99m
The biodistribution of
99
Tc-labeled-tetrasulfophthalocyanine 33 was evaluated in
tumor-bearing rats. Most of the radioactivity accumulated in the liver, kidneys,
ovaries and uterus while tumor uptake was mainly in the exterior cell layers [84].
H
N
N
N
N
N
N
H
N
N
R
R
R
R
R =H; R= SO 3
-
33
72
V. Rajendiran et al.