N
N
N
N
N
N
N
N
R
R
SO 3 Na
R
R = H or SO 3 Na
64 Cu
29
N
N
N
N
N
N
N
N
R
R
SO 3 Na
R
64 Cu
30a: R 1 = R 2 = R 3 = R 4 = SO 3Na;
30b: R 1 = R 2 = R 3 =SO 3 Na R 4 = H;
30c: R 1 = R 2 = SO 3 Na R 3 = R 4 = H;
R 1 = R 3 = SO 3 Na R 2 = R 4 = H;
30d:R 1 = R 2 = R 3 =SO 3 Na R 4 = C 6 H 11
N
N
N
N
N
N
N
N
M
R 2
R 3
R 2
R 3
R 1
R 1
R 3
R 2
R 1
R 2
R 3
R 1
31
Chemical structure of napthalocyanines used.
BNc: M= 2H; R 1 = t-Bu; R 2 ,R 3 =H. VBNc:
M=VO; R 1 = t-Bu; R 2 ,R 3 =H. ZnBNc: M=Zn;R 1
= t-Bu; R 2 ,R 3 =H. ONc: M=2H; R 1 =H; R 2 ,R 3 =O(CH 2 ) 3 CH 3 . Phthalocyanines contain single outer
benzenes. BPc: M= 2H; R 1 = t-Bu; R 2 ,R 3 =H.
VBPc:M=VO; R 1 = t-Bu; R 2 =N(CH 3)2 ; R 3 =H.
3.4.2 Zinc-65
Lier et al. reported the effect of human serum components on the photodynamic
activity of radiolabeled zinc phthalocyanine (ZnPc) toward Chinese hamster
fibroblasts [82]. The association of
65
ZnPc with serum low density lipoproteins
(LDL) and human serum albumin appeared to enhance the photodynamic effect of
this sensitizer.
3 Porphyrin and Phthalocyanine Radiolabeling
71