HN
N
NH
N
N
N
N
N
CH 3
CH 3
CH 3
CH 3
CH 3
H 3 C
H 3 C
H 3 C
H 3 C
H 3 C
CH 3
CH 3
+
+
+
+
SO 3
-
N CH 3
+
21a
21c
21b
HN
N
NH
N
R
R
R
R
R =
N CH3
+
20
N
N
N
N
O
HOOC
COOH
Mn
OOCH 2 C
NCH 2 CH 2 NCH 2 CH 2 N
HOOCH 2 C
CH 2 COOH
CH 2 COOH
CH 2 COOH
H 2 O
22
HN
N
NH
N
N
N
N
E
E'
[(3-E'-4-E)-P]Py 3 PH 2
1- E' = NO 2
E = F
2- E' = H
E = F
3- E' = H
E = O(CH 2 ) 4 NH 2
4- E' = H
E = OCH 2 COOH
5- E' = H
E = OCH 2 -COO
SCH 3
23
3.3.7 Neodymium-140
The b-emitting and t 1/2 = 3.37 days and availability of neodymium-140 make it an
interesting radionuclide for porphyrin labeling [70]. The biodistribution report of
the
140 Nd-labeled 5,10,15,20-tetraphenylporphyrin ((
140 Nd)-TPP) 24 [71] compound in vital organs of Swiss mice bearing fibrosarcoma showed that the complex
is mostly excreted through liver and kidneys.
3 Porphyrin and Phthalocyanine Radiolabeling
67