N
N
N
N
24
Nd
Cl
3.3.8 Holmium-166
b emitting with a 26.8 h half-life,
166 Ho radionuclide is an interesting radionuclide
for targeted therapies [72].
166 Ho-labeled 5,10,15,20-tetrakis(phenyl)porphyrin
((
166 Ho)-TPP) [72] was administered to rats for biodistribution studies. The complex was mostly cleared from the circulation through kidneys and the liver to a
lesser extent.
3.3.9 Lutetium-177
5,10,15,20-tetrakis(4-carboxymethyleneoxyphenyl)porphyrin 25 was synthesized
and coupled with a macrocyclic bi-functional chelating agent, p-amino-benzyl1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid [73]. The porphyrinBFCA conjugate was labeled with
177 Lu for biodistribution and imaging in
Swiss mice bearing either fibrosarcoma or thymic lymphoma tumors. 25 exhibited
specific affinity towards thymic lymphoma compared to fibrosarcoma.
68
V. Rajendiran et al.
N
N
N
24
Nd
Cl
3.3.8 Holmium-166
b emitting with a 26.8 h half-life,
166 Ho radionuclide is an interesting radionuclide
for targeted therapies [72].
166 Ho-labeled 5,10,15,20-tetrakis(phenyl)porphyrin
((
166 Ho)-TPP) [72] was administered to rats for biodistribution studies. The complex was mostly cleared from the circulation through kidneys and the liver to a
lesser extent.
3.3.9 Lutetium-177
5,10,15,20-tetrakis(4-carboxymethyleneoxyphenyl)porphyrin 25 was synthesized
and coupled with a macrocyclic bi-functional chelating agent, p-amino-benzyl1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid [73]. The porphyrinBFCA conjugate was labeled with
177 Lu for biodistribution and imaging in
Swiss mice bearing either fibrosarcoma or thymic lymphoma tumors. 25 exhibited
specific affinity towards thymic lymphoma compared to fibrosarcoma.
68
V. Rajendiran et al.