3.3.6 Indium-111
111 In has received attention in radionanomedicine and has a physical half-life of
2.83 days [65]. An indium labeled water-soluble tetra-4-N-methylpyridyl porphyrin
tosylate (
111 In-T4NMPYP) 20 was prepared and evaluated for selective localization
in melanoma [66]. However, tumor uptake was low compared to
67 Ga-citrate at
48 h. Indium-111-(
111 ln) was labeled tetra (N,N,N-trimethylanilinium) porphyrin
(TTAP) 21a, tetra(4-sulfonatophenyl)porphyrin (T4SPP) 21b and tetra(Nmethyl-4-pyridyl)porphyrin (TMPyP) 21c [66, 67]. Lymph node uptake was
examined and in rats, (
111 In)TTAP showed a maximum lymph node to muscle ratio
[66]. Lymph nodes in rabbits were visualized by gamma scintigraphy 48 h after
intravenous injection of labeled TTAP. Tumor uptake on nuclear scintigraphy
imaging of
111 ln-labeled HPD was investigated in murine mammary adenocarcinomas and breast tumors in Sprague- Dawley female rats [65].
111 ln-HPD selective
uptake was observed in breast tumors.
Nakajima et al. reported a bimodal tumor imaging agent,
111 In-labeled metalloporphyrin (
111 In-ATN-10) 22. It has both a non-radioactive manganese complex
in the porphyrin core and a chelating group attached in its side chain to coordinate
with radioactive
111 In [68]. Three kinds of tumors were imaged with
111 In-ATN-10
and tumors were well-visualized compared to
67 Ga-citrate. Bedel-Cloutour et al.
reported five different monoclonal antibody labeled with hydrosoluble monosubstituted aryl porphyrins 23 [69]. The conjugates exhibited good mAb-labeling
efficiency, as well as preservation of immunoreactivity.
66
V. Rajendiran et al.
111 In has received attention in radionanomedicine and has a physical half-life of
2.83 days [65]. An indium labeled water-soluble tetra-4-N-methylpyridyl porphyrin
tosylate (
111 In-T4NMPYP) 20 was prepared and evaluated for selective localization
in melanoma [66]. However, tumor uptake was low compared to
67 Ga-citrate at
48 h. Indium-111-(
111 ln) was labeled tetra (N,N,N-trimethylanilinium) porphyrin
(TTAP) 21a, tetra(4-sulfonatophenyl)porphyrin (T4SPP) 21b and tetra(Nmethyl-4-pyridyl)porphyrin (TMPyP) 21c [66, 67]. Lymph node uptake was
examined and in rats, (
111 In)TTAP showed a maximum lymph node to muscle ratio
[66]. Lymph nodes in rabbits were visualized by gamma scintigraphy 48 h after
intravenous injection of labeled TTAP. Tumor uptake on nuclear scintigraphy
imaging of
111 ln-labeled HPD was investigated in murine mammary adenocarcinomas and breast tumors in Sprague- Dawley female rats [65].
111 ln-HPD selective
uptake was observed in breast tumors.
Nakajima et al. reported a bimodal tumor imaging agent,
111 In-labeled metalloporphyrin (
111 In-ATN-10) 22. It has both a non-radioactive manganese complex
in the porphyrin core and a chelating group attached in its side chain to coordinate
with radioactive
111 In [68]. Three kinds of tumors were imaged with
111 In-ATN-10
and tumors were well-visualized compared to
67 Ga-citrate. Bedel-Cloutour et al.
reported five different monoclonal antibody labeled with hydrosoluble monosubstituted aryl porphyrins 23 [69]. The conjugates exhibited good mAb-labeling
efficiency, as well as preservation of immunoreactivity.
66
V. Rajendiran et al.