multimodal gut imaging was described [41]. This oral contrast agent passed through
the intestine harmlessly. Furthermore, multimodal nanoparticles using
porphyrin-phospholipid (PoP)-coated upconversion nanoparticles can seamlessly
labeled with
64 Cu (Fig. 3.6) and be employed for PET imaging in a mouse model
simultaneously with five other small animal imaging modalities [42].
Li et al. developed all-in-one multifunctional nanoparticles with combined
diagnostic and therapeutic functions. This porphyrin-based organic nanoconstruct
termed nanoporphyrin was produced by using a single organic building block; a
porphyrin/cholic acid hybrid (Fig. 3.7a) [43]. The agent could be used for PET
imaging (Fig. 3.7b). To increase the sensitivity of this imaging agent, dual-modality
Fig. 3.3 a The structure design of the PPF (Pyro-PKM linker-Folate, molecular weight of 1800 g/
mol). Here the PKM linker (pharmacokinetics modifying linker) is the peptide sequence,
GDEVDGSGK. b Representative MicroPET/CT images (coronal images (top) and single
transverse slices passing through the tumors (bottom)) of KB tumor-bearing mice at 4, 24 h after
intravenous injection of
64
Cu-PPF. c Images, including coronal images (top) and single transverse
slices passing through the tumors (bottom), obtained with pre-injection (0.5 h earlier) of 500-fold
excess folic acid for blockade. Permission obtained from [32]. Copyright (2011) by IVYSPRING
International Publisher
3 Porphyrin and Phthalocyanine Radiolabeling
57
the intestine harmlessly. Furthermore, multimodal nanoparticles using
porphyrin-phospholipid (PoP)-coated upconversion nanoparticles can seamlessly
labeled with
64 Cu (Fig. 3.6) and be employed for PET imaging in a mouse model
simultaneously with five other small animal imaging modalities [42].
Li et al. developed all-in-one multifunctional nanoparticles with combined
diagnostic and therapeutic functions. This porphyrin-based organic nanoconstruct
termed nanoporphyrin was produced by using a single organic building block; a
porphyrin/cholic acid hybrid (Fig. 3.7a) [43]. The agent could be used for PET
imaging (Fig. 3.7b). To increase the sensitivity of this imaging agent, dual-modality
Fig. 3.3 a The structure design of the PPF (Pyro-PKM linker-Folate, molecular weight of 1800 g/
mol). Here the PKM linker (pharmacokinetics modifying linker) is the peptide sequence,
GDEVDGSGK. b Representative MicroPET/CT images (coronal images (top) and single
transverse slices passing through the tumors (bottom)) of KB tumor-bearing mice at 4, 24 h after
intravenous injection of
64
Cu-PPF. c Images, including coronal images (top) and single transverse
slices passing through the tumors (bottom), obtained with pre-injection (0.5 h earlier) of 500-fold
excess folic acid for blockade. Permission obtained from [32]. Copyright (2011) by IVYSPRING
International Publisher
3 Porphyrin and Phthalocyanine Radiolabeling
57