Chapter 23
Therapeutic/Theranostic Use
of Radionanomedicine
So Won Oh and Dong Soo Lee
Abstract Radionanomedicine is a newly emerged field of medicine extending
nuclear medicine by means of nanomaterial technology and platforms.
Radionanomedicine utilizes versatility of nanoparticles (NP) and avoids inherent
toxic effect of NPs. This is mainly due to the fact that NPs are used in trace amounts
for targeting. The therapeutic effect of radionanomedicine comes from ionizing
radiation of labeled radionuclides. The core concept of radionanomedicine depends
on both characteristics of radionuclides and properties of NPs. The characteristics of
NPs including multifunctionality, intrinsic properties are exploited to enhance the
therapeutic effect of radiolabeled NPs. In addition, various strategies have been
developed to deliver sufficient amount of radiolabeled NPs, such as local administration and co-application of thermal stimuli. In an attempt to improve the therapeutic effect of radionuclides, several approaches have been investigated, such as
utilizing intrinsic radioactive properties of NPs or labeling with alpha emitters. The
emergence of radionanomedicine is expected to restore of the essence of nuclear
medicine as well as to enhance the clinical applicability of nanomedicine.
S. W. Oh (&) Á D. S. Lee
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: mdosw@snu.ac.kr
D. S. Lee
e-mail: dsl@snu.ac.kr
S. W. Oh
Department of Nuclear Medicine, Seoul National University
Boramae Medical Center, Seoul 07061, Republic of Korea
D. S. Lee
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology,
Seoul National University, Seoul 03080, Republic of Korea
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_23
431
Therapeutic/Theranostic Use
of Radionanomedicine
So Won Oh and Dong Soo Lee
Abstract Radionanomedicine is a newly emerged field of medicine extending
nuclear medicine by means of nanomaterial technology and platforms.
Radionanomedicine utilizes versatility of nanoparticles (NP) and avoids inherent
toxic effect of NPs. This is mainly due to the fact that NPs are used in trace amounts
for targeting. The therapeutic effect of radionanomedicine comes from ionizing
radiation of labeled radionuclides. The core concept of radionanomedicine depends
on both characteristics of radionuclides and properties of NPs. The characteristics of
NPs including multifunctionality, intrinsic properties are exploited to enhance the
therapeutic effect of radiolabeled NPs. In addition, various strategies have been
developed to deliver sufficient amount of radiolabeled NPs, such as local administration and co-application of thermal stimuli. In an attempt to improve the therapeutic effect of radionuclides, several approaches have been investigated, such as
utilizing intrinsic radioactive properties of NPs or labeling with alpha emitters. The
emergence of radionanomedicine is expected to restore of the essence of nuclear
medicine as well as to enhance the clinical applicability of nanomedicine.
S. W. Oh (&) Á D. S. Lee
Department of Nuclear Medicine, Seoul National University
College of Medicine, Seoul 03080, Republic of Korea
e-mail: mdosw@snu.ac.kr
D. S. Lee
e-mail: dsl@snu.ac.kr
S. W. Oh
Department of Nuclear Medicine, Seoul National University
Boramae Medical Center, Seoul 07061, Republic of Korea
D. S. Lee
Department of Molecular Medicine and Biopharmaceutical Sciences,
Graduate School of Convergence Science and Technology,
Seoul National University, Seoul 03080, Republic of Korea
© Springer International Publishing AG, part of Springer Nature 2018
D. S. Lee (ed.), Radionanomedicine, Biological and Medical Physics,
Biomedical Engineering, https://doi.org/10.1007/978-3-319-67720-0_23
431